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RecruitingLast updated: 2 February 2024

LASER: This phase I trial will evaluate whether stereotactic ablative radiotherapy (SABR) is a safe and effective treatment option for patients with non-small cell lung cancer (NSCLC) whose cancer is large and/or has spread to the nearby lymph nodesTreatment of Locally Advanced non-small cell lung carcinoma with Stereotactic ablativE Radiotherapy

Clinical summary


Stereotactic ablative radiotherapy (SABR) is a specialised form of radiotherapy whereby large doses of radiation are given in fewer treatments. Patients participating in this trial will attend between 6-12 SABR sessions across 2-3 weeks, and will then be followed up regularly post radiotherapy, in order to evaluate treatment safety, quality of life, tumour response and survival.


This trial is treating patients with non-small cell lung cancer


Lung Cancers Lung cancer





Trial Acronym


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Trial Identifiers

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Trial sponsor

Alfred Health

Scientific Title

Treatment of Locally Advanced non-small cell lung carcinoma with Stereotactic ablativE Radiotherapy



- Diagnosis of stage III or IV non-small cell lung carcinoma. Based on clinical or histologic grounds.
- Ineligible for standard of care concurrent chemoradiotherapy as determined by a multidisciplinary group.
- Estimated life expectancy >6 months. Scoring using a Victorian Lung Cancer Prognostic Index is suggested for guidance.
- Recommended a course of radiotherapy to the lung and mediastinal disease.
- Over 18 years of age and available for follow up.


- Previous radiotherapy to the chest.
- History of another primary cancer within the last 2 years, with the exception of non-melanomatous skin cancer and carcinoma in situ of the cervix.
- Significant medical conditions which in the opinion of the investigator would compromise the planned delivery of the radiotherapy or which may be potentially exacerbated by the treatment.
- Pregnant or breast feeding.


  • You have been diagnosed with a prior or secondary type of cancer.
  • You have certain types of non-cancer medical conditions.
  • You have had certain treatments, surgical procedures or drugs.

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

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