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RecruitingLast updated: 1 April 2025

LASER: This phase I trial will evaluate whether stereotactic ablative radiotherapy (SABR) is a safe and effective treatment option for patients with non-small cell lung cancer (NSCLC) whose cancer is large and/or has spread to the nearby lymph nodesTreatment of Locally Advanced non-small cell lung carcinoma with Stereotactic ablativE Radiotherapy

Trial purpose

Medical clipboardCancer treatment

Tumor type

Lung Cancers Lung cancer

Age

People18+

Trial acronym

LASER

Clinical summary

Summary

Stereotactic ablative radiotherapy (SABR) is a specialised form of radiotherapy whereby large doses of radiation are given in fewer treatments. Patients participating in this trial will attend between 6-12 SABR sessions across 2-3 weeks, and will then be followed up regularly post radiotherapy, in order to evaluate treatment safety, quality of life, tumour response and survival.

Conditions

This trial is treating people with non-small cell lung cancer

Eligibility

Inclusion

- Diagnosis of stage III or IV non-small cell lung carcinoma. Based on clinical or histologic grounds.
- Ineligible for standard of care concurrent chemoradiotherapy as determined by a multidisciplinary group.
- Estimated life expectancy >6 months. Scoring using a Victorian Lung Cancer Prognostic Index is suggested for guidance.
- Recommended a course of radiotherapy to the lung and mediastinal disease.
- Over 18 years of age and available for follow up.

Exclusion

- Previous radiotherapy to the chest.
- History of another primary cancer within the last 2 years, with the exception of non-melanomatous skin cancer and carcinoma in situ of the cervix.
- Significant medical conditions which in the opinion of the investigator would compromise the planned delivery of the radiotherapy or which may be potentially exacerbated by the treatment.
- Pregnant or breast feeding.

Exclusion

  • You have been diagnosed with a prior or secondary type of cancer.
  • You have certain types of non-cancer medical conditions.
  • You have had certain treatments, surgical procedures or drugs.
Message

Clinical trials have complex eligibility criteria, and other criteria may apply for this trial. Ask your doctor about whether this trial could be right for you.

Participating hospitals

Recruiting hospitals

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More information

Trial Identifiers

Information on this page is partially produced from ANZCTR *. View further details about this trial on the registry via the links below:

Trial sponsor

Alfred Health

Scientific Title

Treatment of Locally Advanced non-small cell lung carcinoma with Stereotactic ablativE Radiotherapy

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