SGNDV-004: Testing a drug called disitamab vedotin is when given alone, or in addition to targeted therapy, in people with breast or stomach solid cancers that are HER2+A Phase 1b/2 Open-Label Study of Disitamab Vedotin Monotherapy or in Combination With Other Anticancer Therapies in Solid Tumors

Inclusion

General Inclusion Criteria

• Measurable disease according to RECIST v1.1
• Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0 or 1

Dose Escalation and Optimization Phase Inclusion Criteria

• Histologically or cytologically confirmed diagnosis of gastric or gastroesophageal junction adenocarcinoma or breast carcinoma
• Locally-advanced, unresectable, or metastatic stage
• Must have experienced disease progression on or after standard of care therapies or be intolerant of standard of care therapies.

Cohort A (HER2-Low Breast Cancer) Inclusion Criteria

• Histologically or cytologically confirmed diagnosis of breast carcinoma
• Locally-advanced, unresectable, or metastatic stage
• HER2-low status determined by most recent local assessment (IHC 1+ or IHC 2+/ISH-negative)

• Prior therapies requirements

  • No more than 3 prior systemic cytotoxic chemotherapy regimens (including ADCs) for LA/mBC.
  • Participants with known BRCA mutation must have received a PARP-inhibitor where available and not medically contraindicated
  • Have progression on or after, or intolerant to, T-DXd, sacituzumab govitecan, or other topoisomerase I inhibitor therapies, if available as local standard of care therapy

  • Participants with HR+ tumors must have intolerance to endocrine therapy or endocrine therapy refractory disease:

    • Progressed on ≥2 lines of endocrine therapy for LA/mBC AND had received a CDK4/6 inhibitor in the adjuvant or metastatic setting OR
    • Progressed on 1 line of endocrine therapy for LA/mBC AND had a relapse while on adjuvant endocrine therapy after definitive surgery for primary tumor AND had received a CDK4/6 inhibitor in the adjuvant or advanced setting
  • Participants with HR negative, HER2-low and PD-L1-positive (CPS 10 or greater) tumors must have received pembrolizumab with chemotherapy if available as local standard of care therapy.
  • Participants with HR negative, HER2-low and PD-L1-positive (CPS 10 or greater) tumors must have received pembrolizumab (or other PD-(L)1 inhibitor) with chemotherapy if available as local standard of care therapy and not medically contraindicated.

Cohort B (HER2+ Breast Cancer) Inclusion Criteria

• Histologically or cytologically confirmed diagnosis breast carcinoma
• Locally-advanced, unresectable, or metastatic stage
• HER2+ status determined by most recent local assessment (IHC 3+ or IHC 2+/ISH+)

• Participants must have:

  • Received prior trastuzumab, pertuzumab and a taxane if available as local standard of care therapy for advanced disease.
  • Have progression on or after, or intolerant to, T-DXd or other topoisomerase I inhibitor therapies
  • No more than 3 prior systemic cytotoxic chemotherapy regimens (including ADCs) for LA/mBC

Cohort C (HER2-Low Gastric or Gastroesophageal Junction Adenocarcinoma) Inclusion Criteria

• Histologically or cytologically confirmed diagnosis of gastric or gastroesophageal junction adenocarcinoma
• Locally-advanced, unresectable, or metastatic stage
• HER2-low expression defined as IHC 1+ or IHC 2+/ISH-negative determined by most recent local assessment
• Willing and able to provide archival or newly obtained formalin-fixed paraffin-embedded (FFPE) tumor tissue blocks

• Participants must have received:

  • Prior systemic therapy with platinum, fluorouracil, or taxane for locally advanced unresectable or metastatic disease
  • Progression within 6 months of last dose of (neo)adjuvant cytotoxic chemotherapy is considered as 1 line of systemic therapy for LA/mGC/GEJC
  • Prior anti-PD-(L)1 therapy is allowed
  • No more than 2 prior systemic cytotoxic chemotherapy regimens (including ADC) for LA/mGC/GEJC
• Must not have received prior treatment with HER2 directed therapy

Cohort D (HER2+ LA/mGC/GEJC) Inclusion Criteria

• Histologically or cytologically confirmed diagnosis of gastric or gastroesophageal junction adenocarcinoma
• Locally-advanced, unresectable, or metastatic stage
• HER2+ status determined by most recent local assessment (IHC 3+ or IHC 2+/ISH+)

• Participants must have:

  • Received prior trastuzumab plus fluoropyrimidine and platinum containing chemotherapy if no contraindication.
  • Prior T-DXd treatment is allowed
  • Prior PD1 inhibitor therapy is allowed
  • No more than 2 prior systemic cytotoxic chemotherapy regimens (including ADCs) for LA/mGC/GEJC