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RecruitingLast updated: 15 February 2024

RADAR: This study is evaluating the effectiveness of two chemotherapy regimens, with or without, radiation therapy in people with previously untreated Hodgkin LymphomaA Randomised Phase III Trial With a PET Response Adapted Design Comparing ABVD +/- ISRT With A2VD +/- ISRT in Patients With Previously Untreated Stage IA/IIA Hodgkin Lymphoma

Clinical summary


Eligible participants will be randomly allocated to receive either

  • ABVD chemotherapy (consisting of (oxorubicin, bleomycin, vinblastine and dacarbazine) or
  • A2VD chemotherapy (consisting of doxorubicin, brentuximab vedotin, vinblastine and dacarbazine, with growth factor support).

If participants agree, they will have a PET-CT scan after 1 cycle (PET1). The result of this scan will be blinded and used for exploratory endpoints only. Treatment will not be influenced by the result of this scan.

All patients will have a PET-CT scan after 2 cycles of treatment (PET2) which will be centrally reviewed. The Deauville score from central review will be used to risk adapt subsequent therapy as follows:

  • Participants with Deauville score 1-3 will have one further cycle of their randomised chemotherapy and then enter follow up.
  • Participants with Deauville score 4 will have two further cycles of their randomised chemotherapy followed by involved site radiation therapy.
  • Participants with Deuville score 5 will be withdrawn from trial treatment. They will have further treatment at their treating clinician's discretion and will enter follow up for the trial.

Participants with Deauville score 4 on PET2 will have a final PET-CT scan to confirm adequate treatment response.

Participants will be followed up for a minimum of 5 years after completing treatment. 


This trial is treating patients with previously untreated Hodgkin lymphoma


Blood Cancers Haematological


People16 - 69



Trial Acronym


More information

Trial Identifiers

Use the hyperlinks, where available to access additional clinical trial information.

  • NCT04685616
  • 2020-005160-65; IISR X25041; UCL/15/0105; CCTG HD.12

Trial sponsor

University College, London

Scientific Title

A Randomised Phase III Trial With a PET Response Adapted Design Comparing ABVD +/- ISRT With A2VD +/- ISRT in Patients With Previously Untreated Stage IA/IIA Hodgkin Lymphoma



  • Males and females aged 16-69 years (inclusive) (age range is 18-69 in US and EU)
  • Histologically confirmed classical Hodgkin lymphoma
  • Stage I or II supradiaphragmatic disease with no mediastinal bulk disease (defined as greater than a third of the transthoracic diameter at any level of thoracic vertebra as determined by CT) or B symptoms. Bulky disease at other sites is acceptable. Extranodal disease (single extranodal site (stage I) or contiguous nodal extension (stage II)) is acceptable.
  • ECOG performance status 0-2.
  • No previous treatment for Hodgkin lymphoma
  • Fit to receive anthracycline-based chemotherapy (patients with a history of ischaemic heart disease or hypertension should have a left ventricular ejection fraction of ≥50%)
  • Creatinine clearance (measured or calculated >40ml/min
  • Total bilirubin <1.5 x upper limit of normal, unless attributable to disease or known Gilbert's syndrome
  • ALT or AST < 2 x upper limit of normal
  • Adequate bone marrow function with neutrophils ≥1.0x10^9/l and platelets ≥100x10^9/l
  • Haemoglobin ≥8g/dL
  • Willing and able to comply with the requirements of the protocol, including contraceptive advice, where applicable
  • Written informed consent


  • Previous treatment for Hodgkin lymphoma, excluding short courses of oral corticosteroids at a dose of 100mg prednisolone (or equivalent) for up to 7 days
  • Infradiaphragmatic disease
  • Nodular lymphocyte predominant Hodgkin lymphoma
  • Absence of FDG-avid lesions on baseline PET scan
  • Age 70 years or over or age 15 years or under
  • Other cancer diagnosed with the last 5 years. Patients with completely excised carcinoma in situ of any type and basal or squamous cell carcinoma of the skin are not excluded
  • Recurrent or persistent other cancer within last 5 years irrespective of date of initial diagnosis
  • Pre-existing grade ≥1 sensory or motor neuropathy from any cause
  • History of or current progressive multi-focal leukoencephalopathy or other chronic condition of the brain
  • Symptomatic neurologic disease compromising normal activities of daily living or requiring medications
  • Infection with HIV, hepatitis C or active hepatitis B infection (surface antigen or DNA positive)
  • Any active systemic viral, bacterial or fungal infection requiring systemic antibiotics, antivirals or antifungals within 2 weeks prior to first trial drug dose
  • Receiving or recently treated with any other investigational agent (within 4 weeks of trial entry)
  • Pregnant or breastfeeding women
  • Known hypersensitivity to recombinant proteins, murine proteins, or to any excipient contained in the drug formulation of brentuximab vedotin or any component of ABVD
  • Known history of any cardiovascular or respiratory conditions that would preclude anthracycline or bleomycin administration
  • Other significant medical or psychiatric comorbidity that in the opinion of the investigator would make administration of ABVD or A2VD hazardous


  • You have been diagnosed with cancer, but have not received any treatment.


  • You have been diagnosed with a prior or secondary type of cancer.
  • You have certain types of non-cancer medical conditions.
  • You have had certain treatments, surgical procedures or drugs.
  • You have previously been treated (or are currently being treated) on a clinical trial.

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

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