Optimise viewing for

Toggle between patient and health professional views. The patient version is simplified to help people easily find suitable trials, while the professional view provides full detail.

RecruitingLast updated: 22 June 2026

Dara@home: This study is recruiting people with relapsed multiple myeloma to assess the feasibility of patient self-administration of daratumumab targeted therapy in their own homeA phase 2 study of the feasibility and efficacy of at home patient administered subcutaneous daratumumab in patients with relapsed multiple myeloma

Trial purpose

Medical clipboardCancer treatment

Tumor type

Blood Cancers Haematological

Age

People18+

Trial acronym

Dara@home

Clinical summary

Summary

You may be eligible for this study if you have multiple myeloma that has relapsed following first line therapy, and require treatment with daratumumab, bortezomib and dexamethasone.

Daratumumab, bortezomib and dexamethasone are the current standard of care treatment. Daratumumab is currently administered in the hospital. Bortezomib can be administered at home if your hospital has programs in place for this to happen. Dexamethasone is a tablet that you can take in your own home.

The Dara@home trial is to assess the feasibility of implementing a program to allow patients to self-administer daratumumab at home. In addition to standard tests used to treat and monitor your myeloma, this study will have additional questionnaires for you to report your experience with myeloma treatment. There is also an additional blood test to assess the level daratumumab in your blood to ensure that the treatment is working.

It is hoped that findings from this study will give insight on the possibility of having daratumumab to be self-administered at home, which can reduce your visits to the hospital.

Conditions

This trial is treating people with relapsed multiple myeloma

Eligibility

Inclusion

 1. Males or females aged 18 years or older;
2. Have a documented diagnosis of MM according to the International Myeloma Working Group 2016 criteria (Rajkumar 2016);
Note: must include histological confirmation and have measurable disease
3. Have relapsed following first or subsequent-line therapy for MM and require treatment;
Relapse defined as per International Myeloma Working Group definitions
4.Have an ECOG performance score of 0, 1 or 2;
5. Are considered suitable for treatment with daratumumab (in the opinion of the Investigator);
6. In the opinion of the Investigator, are considered suitable for home self-administration (or carer administration); and
7. Have provided written informed consent.

Exclusion

1. Have experienced NCI-CTCAE Grade 2 or worse peripheral neuropathy within the 14 days prior to enrolment;
2. Have any significant mobility issue that would preclude their ability to handle or deliver subcutaneous medications; or
3. Have significant cognitive impairment that, in the Investigator's opinion, would impede appropriate medication use.

Inclusion

  • You have had treatment, but your cancer has come back (relapsed or recurrent).
  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
  • You are able to swallow medication by mouth.

Exclusion

  • You have certain types of non-cancer medical conditions.
Message

Clinical trials have complex eligibility criteria, and other criteria may apply for this trial. Ask your doctor about whether this trial could be right for you.

Participating hospitals

Recruiting hospitals

InformationTell us if you find this trial availability is not accurate.Report inaccuracy

More information

Trial Identifiers

Information on this page is partially produced from ANZCTR *. View further details about this trial on the registry via the links below:

Trial sponsor

Australasian Myeloma Research Consortium

Scientific Title

A phase 2 study of the feasibility and efficacy of at home patient administered subcutaneous daratumumab in patients with relapsed multiple myeloma

Get Support

Peer Connect

You might find it helpful to speak to someone who has 'been there before'. Our Peer Connect program can provide one-on-one phone support from someone who understands what you're going through and has clinical trials experience.

Know more about Peer Connect

Contact cancer support

If you need cancer information and practical support for yourself, a carer, family or friend, contact Cancer Council to speak with an experienced health professional on 13 11 20.

Get support

Multilingual information

Learn more about clinical trials through this collection of resources in languages other than English.

View information