Clinical trials are an important way to improve treatment for people with cancer. While most are continuing during the COVID-19 pandemic, the period of time that clinical trials are available and recruiting may change quickly. If you would like to get involved in a clinical trial, speak to your treatment team or the health service where the clinical trial is being undertaken, to confirm it is open and appropriate for you. For cancer information and support, call Cancer Council's experienced cancer nurses on 13 11 20 Monday to Friday from 9am-5pm.

TOP GEAR : A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer (Other IDs: TROG 08.08, AG0407GR).

Male or<br/>FemaleGender Male or

RecruitingStatus Recruiting

Multiple<Br/>Treatment TypesTypeMultiple
Treatment Types

Two/ThreePhase Two/Three

18-75Age 18-75

Stomach<br/>CancersCancer LocationStomach

Multiple treatment types,Radiotherapy,Systemic therapy | Stomach and upper gastrointestinal tractStomach

Trial Overview Read MoreRead more

This phase II/III trial is comparing preoperative chemradiotherapy with preoperative chemotherapy for patients with resectable gastric cancer.

This trial is treating patients with Stomach (Gastric) and Gastro-Oesophageal Junction Cancers.

This is a systemic therapy and radiotherapy trial.

You may be able to join this trial if:

  • You have been diagnosed with cancer, but have not received any treatment.
  • Your cancer has not spread to other parts of the body.

You may be excluded from this trial if:

  • You have a certain disease or psychological condition.
  • You have been diagnosed with a prior or secondary type of cancer.
  • You have had certain treatments, surgical procedures or drugs.

Clinical trials have complex eligibility criteria - talk to your doctor about your interest in this trial.

Clinical Summary Read MoreRead more

Trial Identifiers

Use the hyperlinks, where available to access additional clinical trial information.

Scientific Title

A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer (Other IDs: TROG 08.08, AG0407GR).

Cooperative Group

Australasian Gastro-Intestinal Trials Group (AGITG)


The main treatment for stomach cancer is surgery. However, even with surgery there is still a risk that the cancer may come back if no further treatment is given. Over the last 5 years, 2 large international studies have shown that giving additional treatment with radiotherapy and chemotherapy may improve the chances of curing patients with stomach cancer. Firstly, a large British study called MAGIC has shown that giving chemotherapy BEFORE and AFTER surgery is better than just surgery alone. Secondly, a large US study called INT0116 has shown that giving combined chemotherapy and radiotherapy together (chemoradiation) AFTER surgery is better than surgery alone. The purpose of this study is to compare these 2 treatments to determine which is better. Unlike in the US study, in this study we will be giving chemoradiation BEFORE surgery (preoperative treatment), rather than AFTER surgery (postoperative treatment). This is because we know from studies in other types of cancers that preoperative treatment is better than postoperative treatment. In addition, preoperative treatment also produces fewer side effects so that patients are more likely to complete the planned treatment. The main aim of this study is therefore to determine if preoperative chemoradiation is more effective than preoperative chemotherapy alone for patients with localised stomach cancer who are going to be treated with surgery. We will also be looking at the side effects of the two treatment combinations.

Recruiting Hospitals Read MoreRead more

Western Health - Sunshine Hospital
St Albans
Ms Heike Raunow
0434 915 739

Not Recruiting Hospitals Read MoreRead more


Austin Health
Ms Samantha Chakar
03 9496 3088

Barwon Health, University Hospital Geelong
Oncology Team

Peter MacCallum Cancer Centre
Moorabbin Research
03 9928 8994

St Vincent's Hospital, Medical and Radiation Oncology
Ms Nadia Ranieri
03 9231 3167

Trial Overview: General information about a clinical trial. This section provides an overview of who might be able to join this trial and what type of treatment is involved.