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Closed (no longer recruiting)Last updated: 13 February 2023

CRSPR: This phase I trial will assess the safety and effectiveness of a new type of immunotherapy, known as CAR T-cell therapy, in patients with advanced renal cell carcinoma that has got worse or not responded to prior treatmentA Phase 1 Dose Escalation and Cohort Expansion Study of the Safety and Efficacy of Allogeneic CRISPR-Cas9-Engineered T Cells (CTX130) in Subjects With Advanced, Relapsed or Refractory Renal Cell Carcinoma With Clear Cell Differentiation

Clinical summary

Summary

This is a does escalation and expansion trial. Eligible patients will be sequentially assigned to receive CTX130 CD70-directed T-cell immunotherapy by IV-infusion following lymphodepleting chemotherapy.

Conditions

This trial is treating patients with renal cell carcinoma.

Cancer

Urinary System Cancers Urinary System

Age

People18+

Phase

I

Trial Acronym

CRSPR

More information

Trial Identifiers

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Commercial Sponsor

CRISPR Therapeutics AG

Scientific Title

A Phase 1 Dose Escalation and Cohort Expansion Study of the Safety and Efficacy of Allogeneic CRISPR-Cas9-Engineered T Cells (CTX130) in Subjects With Advanced, Relapsed or Refractory Renal Cell Carcinoma With Clear Cell Differentiation

Eligibility

Inclusion

  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
  • Your cancer has spread to other parts of the body.

Exclusion

  • You have certain types of non-cancer medical conditions.
  • You have been diagnosed with a prior or secondary type of cancer.
  • You have had certain treatments, surgical procedures or drugs.
Message

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

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Closed hospitals

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