Clinical trials are an important way to improve treatment for people with cancer. While most are continuing during the COVID-19 pandemic, the period of time that clinical trials are available and recruiting may change quickly. If you would like to get involved in a clinical trial, speak to your treatment team or the health service where the clinical trial is being undertaken, to confirm it is open and appropriate for you. For cancer information and support, call Cancer Council's experienced cancer nurses on 13 11 20 Monday to Friday from 9am-5pm.

KEYNOTE-A18 : A Randomized, Phase 3, Double-Blind Study of Chemoradiotherapy With or Without Pembrolizumab for the Treatment of High-risk, Locally Advanced Cervical Cancer

Female<br/>OnlyGender Female
Only

RecruitingStatus Recruiting

Multiple<Br/>Treatment TypesTypeMultiple
Treatment Types

ThreePhase Three

18+Age Over 18

Female Reproductive<br/>System CancersCancer LocationFemale Reproductive
System Cancers

Multiple treatment types,Radiotherapy,Systemic therapy | Female reproductive organsCervix

Trial Overview Read MoreRead more

This phase III trial is evaluating the safety and effectiveness of using chemo-radiotherapy with or without immunotherapy for the treatment of patients with locally advanced cervical cancer .
 

This trial is treating patients with cervical cancer.

This is a systemic therapy and radiotherapy trial.

You may be excluded from this trial if:

  • You have a certain disease or psychological condition.
  • You have had certain treatments, surgical procedures or drugs.
  • You have previously been treated (or are currently being treated) on a clinical trial.

Clinical trials have complex eligibility criteria - talk to your doctor about your interest in this trial.

Clinical Summary Read MoreRead more

Trial Identifiers

Use the hyperlinks, where available to access additional clinical trial information.

Scientific Title

A Randomized, Phase 3, Double-Blind Study of Chemoradiotherapy With or Without Pembrolizumab for the Treatment of High-risk, Locally Advanced Cervical Cancer

Cooperative Group

European Network for Gynaecological Oncological Trial Groups & the Gynecologic Oncology Group

Commercial Sponsor

Merck

Summary

Eligible patients will be randomised to receive standard of care chemo-radiotherapy with cisplatin and external beam radiotherapy and brachytherapy, in addition to pembrolizumab or a pembrolizumab-placebo, to understand the impact on progression-free survival and overall survival.

Recruiting Hospitals Read MoreRead more

Monash Health, Medical Oncology
Clayton
Breast and Gynaecology Research Study Coordinator
breastgynae.oncresearch@monashhealth.org
0491299561

Not Recruiting Hospitals Read MoreRead more

Completed

PCCTU (Parkville Cancer Clinical Trials Unit) *
Parkville
Sally Mongta
PCCTU.Gynae@petermac.org

Trial Overview: General information about a clinical trial. This section provides an overview of who might be able to join this trial and what type of treatment is involved.

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