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Closed (no longer recruiting)Last updated: 29 May 2023

IV Sting: This phase I trial is trying to determine the recommended dose of a new intravenous therapy (GSK3745417), when given alone or in combination with a type of immunotherapy, in patients with solid cancer typesA Phase I First Time in Human Open Label Study of GSK3745417 Administered With and Without Anticancer Agents in Participants With Advanced Solid Tumors

Clinical summary

Summary

This is a dose escalation and expansion trial. In part 1 of the study, participants will receive an intravenous dose of GSK3745417 alone, at one week intervals. In part 2, GSK3745417 will be co-administered with 200mg IV pembrolizumab once every three weeks.

Conditions

This trial is treating patients with solid cancers.

Cancer

Advanced Cancers Advanced

Age

People18+

Phase

I

Trial Acronym

IV Sting

More information

Trial Identifiers

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Commercial Sponsor

GlaxoSmithKline

Scientific Title

A Phase I First Time in Human Open Label Study of GSK3745417 Administered With and Without Anticancer Agents in Participants With Advanced Solid Tumors

Eligibility

Inclusion

  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.

Exclusion

  • You have certain types of non-cancer medical conditions.
  • You have had certain treatments, surgical procedures or drugs.
Message

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

Participating hospitals

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Closed hospitals

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Victorian Cancer Registry Victorian Government

The Victorian Cancer Trials Link is supported by the Victorian Government through the Victorian Cancer Agency.

RAP

Cancer Council Victoria would like to acknowledge the traditional custodians of the land on which we live and work. We would also like to pay respect to the elders past and present and extend that respect to all other Aboriginal people.