This phase III trial is assessing the safety and effectiveness of combining treatment with an oral targeted cancer drug (olaparib) and a type of immunotherapy (pembrolizumab) in patients with castrate-resistant prostate cancer that has spread to other parts of the body and not responded to prior treatments.
This trial is treating patients with castration-resistant prostate cancer.
This is a systemic therapy trial.
You may be able to join this trial if:
- You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
- Your cancer has spread to other parts of the body.
You may be excluded from this trial if:
- You have a certain disease or psychological condition.
- You have been diagnosed with a prior or secondary type of cancer.
- You have had certain treatments, surgical procedures or drugs.
- You have previously been treated (or are currently being treated) on a clinical trial.
Clinical trials have complex eligibility criteria - talk to your doctor about your interest in this trial.
Clinical Summary Read More
Use the hyperlinks, where available to access additional clinical trial information.
A Phase 3, Randomized Open-label Study of Pembrolizumab (MK-3475) Plus Olaparib Versus Abiraterone Acetate or Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) Who Are Unselected for Homologous Recombination Repair Defects and Have Failed Prior Treatment With One Next-generation Hormonal Agent (NHA) and Chemotherapy
Eligible participants will be randomised to receive the trial treatment (olaparib and pembrolizumab) or an active comparator (abiraterone acetate and prednisone, or enzalutamide depending on treatment history) until disease progression.
Recruiting Hospitals Read More