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RecruitingLast updated: 28 April 2022

M14-728: This phase II trial is evaluating an oral chemotherapy drug (Venetoclax) in participants with Chronic Lymphocytic Leukaemia (CLL)A Phase 2 Open-Label Study of the Efficacy of Venetoclax in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia in the Presence of 17p Deletion

Clinical summary

Summary

Participants in this trial will receive Venetoclax via oral administration, starting with a 20mg dose once daily (QD). Dose escalation will occur weekly in the following progression: 50mg QD, 100mg QD, 200mg QD, 400mg QD, as tolerated.

Conditions

This trial is treating patients with Chronic Lymphocytic Leukaemia (CLL).

Cancer

Blood Cancers Blood

Age

People18+

Phase

II

Trial Acronym

M14-728

More information

Trial Identifiers

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Commercial Sponsor

AbbVie

Scientific Title

A Phase 2 Open-Label Study of the Efficacy of Venetoclax in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia in the Presence of 17p Deletion

Eligibility

Inclusion

  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.

Exclusion

  • You have certain types of non-cancer medical conditions.
  • You have been diagnosed with a prior or secondary type of cancer.
  • You have had certain treatments, surgical procedures or drugs.
  • You have previously been treated (or are currently being treated) on a clinical trial.
Message

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

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The Victorian Cancer Trials Link is supported by the Victorian Government through the Victorian Cancer Agency.

RAP

Cancer Council Victoria would like to acknowledge the traditional custodians of the land on which we live and work. We would also like to pay respect to the elders past and present and extend that respect to all other Aboriginal people.