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RecruitingLast updated: 3 May 2019

SCOUT: This phase I/II trial is using an oral drug (LOXO-101) as a treatment in children and adolescents with central nervous system tumoursA Phase 1/2 Study of the Oral TRK Inhibitor LOXO-101 (Larotrectinib) in Pediatric Patients With Advanced Solid or Primary Central Nervous System Tumors

Clinical summary

Summary

This trial has a single group assignment; all participants will receive oral LOXO-101 (larotrectinib) twice daily, with dose adjusted for body surface area (BSA).

Conditions

This trial is treating patients with central nervous system tumours.

Cancer

Brain and Spinal Cancers Brain and Spinal

Age

People>21

Phase

I/II

Trial Acronym

SCOUT

More information

Trial Identifiers

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Commercial Sponsor

LOXO Oncology, Inc

Scientific Title

A Phase 1/2 Study of the Oral TRK Inhibitor LOXO-101 (Larotrectinib) in Pediatric Patients With Advanced Solid or Primary Central Nervous System Tumors

Eligibility

Inclusion

  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.

Exclusion

  • You have certain types of non-cancer medical conditions.
  • You have had certain treatments, surgical procedures or drugs.
  • You have previously been treated (or are currently being treated) on a clinical trial.
Message

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

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