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RecruitingLast updated: 4 July 2023

NEO-N: This phase II trial is trying to understand whether using a type of immunotherapy (Nivolumab) before starting standard chemotherapy will have a different effect on reducing tumour size for patients with early stage triple negative breast cancer, compared to if the immunotherapy and chemotherapy were given at the same timeA randomised phase II trial evaluating the efficacy of a nivolumab monotherapy lead in “window” or commencement of nivolumab concurrently with paclitaxel and carboplatin as neoadjuvant therapy in early stage triple negative breast cancers

Clinical summary

Summary

Eligible patients will be randomised to receive (1) Nivolumab alone for two weeks, followed by Nivolumab + Carboplatin + Paclitaxel for a further 12 weeks, followed by surgery; or (2) Nivolumab + Carboplatin + Paclitaxel for 12 weeks.

Conditions

This trial is treating patients with triple negative breast cancer.

Cancer

Breast Cancers Breast

Age

People18+

Phase

II

Trial Acronym

NEO-N

More information

Trial Identifiers

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Commercial Sponsor

Breast Cancer Trials

Scientific Title

A randomised phase II trial evaluating the efficacy of a nivolumab monotherapy lead in “window” or commencement of nivolumab concurrently with paclitaxel and carboplatin as neoadjuvant therapy in early stage triple negative breast cancers

Eligibility

Inclusion

  • You have been diagnosed with cancer, but have not received any treatment.
  • Your cancer has not spread to other parts of the body.

Exclusion

  • You have certain types of non-cancer medical conditions.
  • You have been diagnosed with a prior or secondary type of cancer.
  • You have had certain treatments, surgical procedures or drugs.
  • You have previously been treated (or are currently being treated) on a clinical trial.
Message

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

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Victorian Cancer Registry Victorian Government

The Victorian Cancer Trials Link is supported by the Victorian Government through the Victorian Cancer Agency.

RAP

Cancer Council Victoria would like to acknowledge the traditional custodians of the land on which we live and work. We would also like to pay respect to the elders past and present and extend that respect to all other Aboriginal people.