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Circulating Tumour DNA Analysis Informing Adjuvant Chemotherapy in Locally Advanced Rectal Cancer: A Multicentre Randomised Study
Australasian Gastro-Intestinal Trials Group (AGITG)
Other Non-Commercial Sponsor
National Health & Medical Research Council (NHMRC)
This trial will involve collecting blood for a ctDNA analysis in patients with locally advanced rectal cancer who have undergone pre-operative long course chemo-radiation and surgery. Based on the results of the ctDNA analysis, patients will be randomized into one of two arms. In the ctDNA-informed arm, participants will receive chemotherapy which will consist of either either 5FU or Capecitabine with or without Oxaliplatin, based on a positive ctDNA or negative ctDNA result. In the standard of care (SOC) arm, participants will receive chemotherapy based on a standard pathology risk assessment of their cancer.