Clinical trials are an important way to improve treatment for people with cancer. While most are continuing during the COVID-19 pandemic, the period of time that clinical trials are available and recruiting may change quickly. If you would like to get involved in a clinical trial, speak to your treatment team or the health service where the clinical trial is being undertaken, to confirm it is open and appropriate for you. For cancer information and support, call Cancer Council's experienced cancer nurses on 13 11 20 Monday to Friday from 9am-5pm.

SHRINC : A Phase II Prospective Trial of Stereotactic Hypofractionated Radiation for Multiple (3-10) cerebral metastases including Neurological and Cognitive assessment

Male or<br/>FemaleGender Male or

RecruitingStatus Recruiting


TwoPhase Two

18+Age Over 18

Advanced CancersCancer LocationMulti-Cancer

Radiotherapy | Bowel (colorectum),Brain and spinal cord,Breast,Female reproductive organs,Head and neck,Lung,Sarcoma,Skin,Stomach and upper gastrointestinal tract,Urinary systemAnus,Astrocytoma,Basal cell carcinoma,Bile duct,Bladder,Bone,Brain,Brain stem,Breast,Cervix,Chondrosarcoma,Colon,Colorectum,Cutaneous Squamous Cell Carcinoma (CSCC),Endometrium,Ependymomas,Epithelial,Ewing's Sarcoma,Fallopian tube,Gallbladder,Gastrointestinal stromal tumour (GIST),Gastro-oesophageal junction ,Germ cell and sex cord stromal cell,Glioma,Kidney,Leiomyosarcoma,Liposarcoma,Liver,Medullablastoma,Melanoma (Ocular),Melanoma (Skin),Meningioma,Merkel cell,Mesothelioma,Neuroblastoma,Neuroendocrine tumours,Non-Small Cell Lung Cancer,Nose (nasopharynx),Oesophagus,Oral cavity,Oropharynx,Osteosarcoma,Ovary,Pancreas,Penis,Peritoneal,Prostate,Rectum,Renal cell carcinoma,Rhabdomyosarcoma,Salivary glands,Sarcoma,Small Cell Lung Cancer,Soft Tissue Sarcoma,Spinal Cord,Stomach,Synovial Sarcoma,Testis,Throat (hypopharynx),Thyroid,Urinary tract,Urothelial,Uterus,Vagina,Voice box (larynx),Vulva

Trial Overview Read MoreRead more

This phase II trial is assessing a type of radiotherapy treatment for patients whose cancer has spread to the brain.

This trial is treating patients with advanced cancer that has spread to the brain.

This is a radiotherapy trial.

You may be able to join this trial if:

  • Your cancer has spread to other parts of the body.

You may be excluded from this trial if:

  • You have a certain disease or psychological condition.
  • You have had certain treatments, surgical procedures or drugs.

Clinical trials have complex eligibility criteria - talk to your doctor about your interest in this trial.

Clinical Summary Read MoreRead more

Trial Identifiers

Use the hyperlinks, where available to access additional clinical trial information.

Scientific Title

A Phase II Prospective Trial of Stereotactic Hypofractionated Radiation for Multiple (3-10) cerebral metastases including Neurological and Cognitive assessment

Other Non-Commercial Sponsor

Intergrated Clinical Oncology Network Pty Ltd (ICON)


The purpose of this study is to investigate whether improved radiation planning technology that conforms to the shape and size of the cancer, can be used to treat multiple sites of cancer within the brain, and at the same time protect and preserve your brain (memory and cognitive) function. Who is it for? You may be eligible to join this study if you are aged 18 years or above and have been diagnosed with 3-10 measurable cerebral metastases, i.e. your cancer has spread to three or more spots on the brain. Study details: All participants in this study will receive a new treatment called Hypofractionated Stereotactic Radiotherapy. This is highly focused radiation given in one or a few (5-6) treatments. Robotic targeting is used to avoid important parts of the normal brain. Where previous treatment for multiple sites of cancer within the brain has involved giving radiation to the whole brain, this treatment will allow us to treat multiple areas at the same time. The aim is to avoid the use of whole brain radiation that can affect the memory structures within the brain such as the hippocampus, thus preserving brain (memory and cognitive) function. The trial will use software called "BrainLab Elements (Trademark)". This software will help the radiation oncologist to plan and deliver the radiotherapy treatment. All participants will be monitored throughout treatment for safety. They will also be asked to undergo MRI scans and complete some questionnaires at the start of the study and at 3 and 6 months after treatment to assess neurocognitive functioning, disease response, and quality of life. We estimate that this study will contribute further to the research into using radiotherapy to control cancers that have spread to the brain, while minimising the effects on brain function.

Recruiting Hospitals Read MoreRead more

Icon Cancer Centre
Skye Nolan
03 9936 8277

Trial Overview: General information about a clinical trial. This section provides an overview of who might be able to join this trial and what type of treatment is involved.