Trial Identifiers
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Scientific Title
A Phase III, multi-centre, multi-national randomised control trial investigating 1cm v 2cm wide excision margins for primary cutaneous melanoma.
Cooperative Group
Australia and New Zealand Melanoma Trials Group (ANZMTG)
Summary
This study will determine whether there is a difference in local recurrence rates and melanoma survival rates for patients treated with either a 1cm excision margin or 2cm margin for both intermediate & high risk melanomas.
Who is it for?
You may be eligible to joint this study if you aged 18 years or above and have been diagnosed with a primary invasive cutaneous melanoma greater than 1mm thick.
Study details
Whilst patients with a primary invasive melanoma are generally recommended to undergo excision of the primary lesion with a wide margin, there is evidence that less radical margins of excision may be just as safe. Participants in this study are randomly allocated (by chance) to one of two groups. Participants in one group will undergo surgery with the 2cm excision margin, whilst participants in the other group will undergo surgery with a 1cm excision margin.
Participants will be monitored for up to 60 months, in order to determine melanoma recurrence, survival rates and quality of life, and additionally, adverse events and health resource usage.