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Whole brain radiotherapy following local treatment of intracranial metastases of melanoma. A randomised phase III trial (Other IDs: ANZMTG 1-07).
Australia and New Zealand Melanoma Trials Group (ANZMTG)
People in Australia with brain metastases from melanoma are currently offered whole brain radiotherapy (WBRT) after brain surgery depending on which hospital they attend. This trial seeks to determine if WBRT reduces the spread of melanoma in the brain, and lengthens the time to melanoma returning. This trial will also examine the effect of WBRT on quality of life and brain functions such as memory, speech and concentration. Participants will be randomised to either whole brain radiotherapy or observation following their surgery. 200 people will be recruited from melanoma centres in Australia, New Zealand and other international sites.