Clinical trials are an important way to improve treatment for people with cancer. While most are continuing during the COVID-19 pandemic, the period of time that clinical trials are available and recruiting may change quickly. If you would like to get involved in a clinical trial, speak to your treatment team or the health service where the clinical trial is being undertaken, to confirm it is open and appropriate for you. For cancer information and support, call Cancer Council's experienced cancer nurses on 13 11 20 Monday to Friday from 9am-5pm.

DREAM3R : DuRvalumab (MEDI4736) With chEmotherapy as First Line treAtment in Advanced Pleural Mesothelioma - A Phase 3 Randomised Trial

Male or<br/>FemaleGender Male or

RecruitingStatus Recruiting

Systemic<br/>Therapy TrialTypeSystemic
Therapy Trial

ThreePhase Three

18+Age Over 18

Lung<br/>CancersCancer LocationLung

Systemic therapy,Treatment | LungLung,Mesothelioma

Trial Overview Read MoreRead more

This phase III trial is trying to understand whether adding a form of targeted therapy to standard chemotherapy will improve overall survival for patients with malignant pleural mesothelioma.

This trial is treating patients with malignant pleural mesothelioma.

This is a systemic therapy trial.

You may be excluded from this trial if:

  • You have a certain disease or psychological condition.
  • You have been diagnosed with a prior or secondary type of cancer.
  • You have had certain treatments, surgical procedures or drugs.
  • You have previously been treated (or are currently being treated) on a clinical trial.

Clinical trials have complex eligibility criteria - talk to your doctor about your interest in this trial.

Clinical Summary Read MoreRead more

Trial Identifiers

Use the hyperlinks, where available to access additional clinical trial information.

Scientific Title

DuRvalumab (MEDI4736) With chEmotherapy as First Line treAtment in Advanced Pleural Mesothelioma - A Phase 3 Randomised Trial

Cooperative Group

Australasian Lung Cancer Trials Group (ALTG)

Commercial Sponsor

PrECOG, LLC & AstraZeneca

Other Non-Commercial Sponsor

University of Sydney


Two thirds of eligible patients will be randomly assigned to receive durvalumab in addition to standard chemotherapy containing pemetrexed and cisplatin. One third of eligible patients will receive chemotherapy alone, followed by observation.

Recruiting Hospitals Read MoreRead more

Austin Health
Ms Samantha Chakar
03 9496 3088

Border Medical Oncology
Jacqui McBurnie

02 6064 1500

Goulburn Valley Health
Ms Carole Mott
(03) 5832 3777

Monash Health, Medical Oncology
Lung and Head & Neck Research Study Coordinator

PCCTU (Parkville Cancer Clinical Trials Unit) *
Monc B Co-Team Leads

Western Health - Sunshine Hospital
St Albans
Ms Heike Raunow
0434 915 739

Trial Overview: General information about a clinical trial. This section provides an overview of who might be able to join this trial and what type of treatment is involved.