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RecruitingLast updated: 15 August 2023

SUCCESSOR-2: This phase III study is investigating whether adding a new targeted therapy (CC-92480) to the combination treatment of targeted therapy and steroids (carfilzomib and dexamethasone) improves the effectiveness of treating multiple myelomaA Phase 3, Two-stage, Randomized, Multicenter, Open-label Study Comparing CC-92480 (BMS-986348), Carfilzomib, and Dexamethasone (480Kd) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

Clinical summary

Summary

Eligible participants will be randomly allocated to either the Experimental Arm or the Active Comparator Arm. In the Experimental Arm, participants will receive CC-92480 + carfilzomib + dexamethasone). In the Active Comparator Arm, participants will receive carfilzomib + dexamethasone.

Conditions

This trial is treating patients with relapsed or refractory multiple myeloma.

Cancer

Blood Cancers Blood

Age

People18+

Phase

III

Trial Acronym

SUCCESSOR-2

More information

Trial Identifiers

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Commercial Sponsor

Bristol-Myers Squibb (BMS)

Scientific Title

A Phase 3, Two-stage, Randomized, Multicenter, Open-label Study Comparing CC-92480 (BMS-986348), Carfilzomib, and Dexamethasone (480Kd) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

Eligibility

Inclusion

  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
  • You have had treatment, but your cancer has come back.

Exclusion

  • You have had certain treatments, surgical procedures or drugs.
Message

Clinical trials have complex eligibility criteria.

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Participating hospitals

Recruiting hospitals

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The Victorian Cancer Trials Link is supported by the Victorian Government through the Victorian Cancer Agency.

RAP

Cancer Council Victoria would like to acknowledge the traditional custodians of the land on which we live and work. We would also like to pay respect to the elders past and present and extend that respect to all other Aboriginal people.