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RecruitingLast updated:15 August 2023

PARLuNET: This phase I trial is evaluating how safe and tolerable a targeted therapy (talazoparib) is in combination with radionuclide therapy (177Lu-DOTA-Octreotate) in people with metastatic pancreatic neuroendocrine cancerPhase 1 Trial of PARP Inhibitor Combined With 177Lu-DOTA-Octreotate Peptide Receptor Radionuclide Therapy (PRRT) in Patients With Metastatic NeuroEndocrine Tumor

Clinical summary

Summary

All eligible participants will receive 4 cycles of 177Lu-DOTA-Octreotate peptide receptor radionuclide therapy (PRRT) every 8 weeks, with the last 3 cycles being combined with talazoparib. Talazoparib will be administered in escalating doses, orally, daily during days 2-6 of these cycles.

Age

People18+

Phase

I

Trial Acronym

PARLuNET

More information

Trial Identifiers

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Commercial Sponsor

Peter MacCallum Cancer Centre

Scientific Title

Phase 1 Trial of PARP Inhibitor Combined With 177Lu-DOTA-Octreotate Peptide Receptor Radionuclide Therapy (PRRT) in Patients With Metastatic NeuroEndocrine Tumor

Eligibility

Inclusion

  • You have certain types of non-cancer medical conditions.
  • You have had certain treatments, surgical procedures or drugs.
  • You have previously been treated (or are currently being treated) on a clinical trial.

Exclusion

  • You are able to swallow medication by mouth.
  • Your cancer has spread to other parts of the body.
Message

Clinical trials have complex eligibility criteria.

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