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RecruitingLast updated:15 August 2023

PROTAC CLL: This Phase I trial is seeking to understand the recommended dose of a targeted therapy (BGB-16673) in people with B-Cell MalignanciesA Phase 1, Open-Label, Dose-Escalation and -Expansion Study of the Bruton Tyrosine Kinase-Targeted Protein-Degrader BGB-16673 in Patients With B-Cell Malignancies

Clinical summary

Summary

This is a non-randomised trial trial with two parts in people with B-Cell Malignancies including Marginal Zone Lymphoma, Follicular Lymphoma, Non-Hodgkin Lymphoma, and Waldenström Macroglobulinemia. In Part 1 (Monotherapy Dose Finding) participants will receive BGB-16673 administered as a once daily regimen. In Part 2 (two Expansion cohorts) BGB-16673 will also be administered as a once daily regimen.

Age

People18+

Phase

I

Trial Acronym

PROTAC CLL

More information

Trial Identifiers

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Commercial Sponsor

BeiGene Australia Pty Ltd

Scientific Title

A Phase 1, Open-Label, Dose-Escalation and -Expansion Study of the Bruton Tyrosine Kinase-Targeted Protein-Degrader BGB-16673 in Patients With B-Cell Malignancies

Eligibility

Inclusion

  • You have been diagnosed with a prior or secondary type of cancer.
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