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RecruitingLast updated:29 August 2023

MOST-CIRCUIT: This phase II trial is trying to determine the clinical benefit of using two types of immunotherapy (nivolumab combined with ipilimumab) to treat neuroendocrine cancers, biliary tract cancers, gynaecological cancers and MSI-H cancers (excluding colorectal cancer)Ipilimumab and Nivolumab Combination Therapy in Patients With Selected Immunotherapy Sensitive Advanced Rare Cancers

Clinical summary

Summary

Eligible participants will be treated with Nivolumab (3 mg/kg) and ipilimumab (1 mg/kg) concurrently every 3 weeks for 4 doses, followed by nivolumab (480mg) only every 4 weeks until progression (up to 2 years).

Age

People18+

Phase

II

Trial Acronym

MOST-CIRCUIT

More information

Trial Identifiers

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Commercial Sponsor

Olivia Newton-John Cancer Research Institute

Scientific Title

Ipilimumab and Nivolumab Combination Therapy in Patients With Selected Immunotherapy Sensitive Advanced Rare Cancers

Eligibility

Inclusion

  • You have certain types of non-cancer medical conditions.
  • You have been diagnosed with a prior or secondary type of cancer.
  • You have had certain treatments, surgical procedures or drugs.
Message

Clinical trials have complex eligibility criteria.

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