InformationClinical trials have complex eligibility criteria.
Always talk to your clinician about you’re interest in participating in a trial.
Learn why

Optimise reading forHealth ProfessionalsPatients

RecruitingLast updated:15 August 2023

DECREASE: This phase II trial is investigating the use of local consolidation radiotherapy in men with non-metastatic, castrate resistant prostate cancerDarolutamide + Consolidation Radiotherapy in Advanced Prostate Cancer Detected by PSMA

Clinical summary


This trial will test the hypothesis that the addition of consolidation radiotherapy to darolutamide will improve the clinical outcome of patients, compared to those patients receiving darolutamide alone. Patients will be randomised to receive 600mg darolutimide alone, twice daily, or in combination with local consolidative radiotherapy.





Trial Acronym


More information

Trial Identifiers

Use the hyperlinks, where available to access additional clinical trial information.

Commercial Sponsor

Bayer Inc, Trans Tasman Radiation Oncology Group (TROG)

Scientific Title

Darolutamide + Consolidation Radiotherapy in Advanced Prostate Cancer Detected by PSMA



  • You have been diagnosed with a prior or secondary type of cancer.
  • You have had certain treatments, surgical procedures or drugs.


  • You are able to swallow medication by mouth.
  • Your cancer has not spread to other parts of the body.

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

Participating hospitals

Recruiting hospitals

InformationTell us if you find this trial availability is not accurate.Report inaccuracy

Get Support


Cancer Connect

Speak with someone who has cancer clinical trial experience.

Learn more


Cancer Council’s cancer nurses

If you need cancer information and practical support for yourself, a carer, family or friend, contact Cancer Council’s experienced cancer nurses on 131120.

Learn more


Information for family, friends and carers

When you are considering a cancer clinical trial, it is a good idea to discuss it with your family, friends or carers.

Learn more