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RecruitingLast updated:15 August 2023

DECREASE: This phase II trial is investigating the use of local consolidation radiotherapy in men with non-metastatic, castrate resistant prostate cancerDarolutamide + Consolidation Radiotherapy in Advanced Prostate Cancer Detected by PSMA

Clinical summary

Summary

This trial will test the hypothesis that the addition of consolidation radiotherapy to darolutamide will improve the clinical outcome of patients, compared to those patients receiving darolutamide alone. Patients will be randomised to receive 600mg darolutimide alone, twice daily, or in combination with local consolidative radiotherapy.

Age

People18+

Phase

II

Trial Acronym

DECREASE

More information

Trial Identifiers

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Commercial Sponsor

Bayer Inc, Trans Tasman Radiation Oncology Group (TROG)

Scientific Title

Darolutamide + Consolidation Radiotherapy in Advanced Prostate Cancer Detected by PSMA

Eligibility

Inclusion

  • You have been diagnosed with a prior or secondary type of cancer.
  • You have had certain treatments, surgical procedures or drugs.

Exclusion

  • You are able to swallow medication by mouth.
  • Your cancer has not spread to other parts of the body.
Message

Clinical trials have complex eligibility criteria.

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