Clinical trials are an important way to improve treatment for people with cancer. While most are continuing during the COVID-19 pandemic, the period of time that clinical trials are available and recruiting may change quickly. If you would like to get involved in a clinical trial, speak to your treatment team or the health service where the clinical trial is being undertaken, to confirm it is open and appropriate for you. For cancer information and support, call Cancer Council's experienced cancer nurses on 13 11 20 Monday to Friday from 9am-5pm.

Results

Systemic therapy trial

TiNivo-2: A Phase 3, Randomized, Controlled, Multicenter, Open-label Study to Compare...

This phase III study is comparing the effectiveness of targeted therapy alone (tivozanib) to targeted therapy plus immunotherapy (tivozanib + nivolumab) in people with advanced kidney cancer who have had prior treatment

Cancer type : Renal cell carcinoma

Systemic therapy trial

A Phase 2 Open-Label Trial to Evaluate Enoblituzumab in Combination With Retifanlimab or...

This Phase II trial is evaluating combinations of targeted therapies (enoblituzumab, retifanlimab and tebotelimab) in people with recurrent or metastatic squamous cell carcinoma of the head and neck

Cancer type : Head and neck

Systemic therapy trial

ACE-Breast03 : A Global, Phase 2 Study of ARX788 in HER2-positive, Metastatic Breast Cancer Patients...

This Phase II trial is trying to understand the effectiveness of a new targeted therapy (ARX788) in people with HER2-positive metastatic breast cancer who have not responded to other targeted therapies (T-DM1, T-DXd, Tucatinib)

Cancer type : Breast

Systemic therapy trial

CONTACT-02 : A Phase 3, Randomized, Open-Label, Controlled Study of Cabozantinib (XL184) in...

This phase III trial is comparing a type of targeted therapy with a novel hormonal therapy (NHT) in men who have previously received one NHT for their castration resistant prostate cancer that has spread to other parts of the body

Cancer type : Prostate

Systemic therapy trial

Magrolimab : A Phase 2, Randomized, Open-Label Study Evaluating the Safety and Efficacy of Magrolimab...

This trial is evaluating the addition of a targeted cancer drug (Magrolimab) to chemotherapy (using Nab-Paclitaxel or Paclitaxel) for the treatment of people with triple negative breast cancer that has spread to other parts of the body

Cancer type : Breast

Systemic therapy trial

ENHANCE : A Randomized, Double-blind, Multicenter Study Comparing Magrolimab in Combination With...

This phase III trial is testing the addition of a targeted therapy drug to treatment for previously untreated patients with intermediate-very high risk myelodysplastic syndromes (MDS)

Cancer type : Myelodysplasia

Systemic therapy trial

MAJIC : A Phase III Prospective, Multicenter, Randomized, Open-Label Trial of Acalabrutinib Plus...

This phase III study is comparing the effectiveness of two different combinations of targeted therapies (acalabrutinib + venetoclax versus venetoclax + obinutuzumab) in people with previously untreated chronic lymphocytic leukaemia or small lymphocytic lymphoma

Cancer type : Blood

Systemic therapy trial

AMLM26/T5 INTERCEPT : AMLM26/T5- INTERCEPT (Investigating Novel Therapy to Target Early Relapse and Clonal...

This phase I/II study is evaluating the effective a new treatment (MBG453) alone, and in combination with another treatment (azacitadine), in people with progressive acute myeloid leukaemia

Cancer type : Acute Myeloid Leukaemia

Multiple treatment types

Ave-Rec study : Phase II Trial PD-L1/PD-1 Blockade Avelumab (MSB0010718C) With Chemoradiotherapy for...

This phase II trial is evaluating the addition of an immunotherapy drug following long-course chemo-radiotherapy in patients with a locally advanced rectal cancer that is able to be surgically removed

Cancer type : Rectum

Systemic therapy trial

FLAURA2 : A Phase III, Open-label, Randomized Study of Osimertinib With or Without Platinum Plus...

This phase III trial is trying to determine whether it is more or less effective to use an oral targeted therapy alone or in combination with a type of chemotherapy for the treatment of advanced non-small cell lung cancer

Cancer type : Non-Small Cell Lung Cancer

Systemic therapy trial

LIBRETTO-431 : A Multicenter, Randomized, Open-Label, Phase 3 Trial Comparing LOXO-292 to Platinum-Based...

This phase III trial is comparing a new oral therapy (Selpercatinib) with a standard treatment in patients with advanced non-small cell lung cancer

Cancer type : Lung

Systemic therapy trial

WU-KONG1 : A Phase I/II, Open-Label, Multicenter Study to Assess the Safety, Tolerability,...

This phase I/II trial is evaluating the effectiveness and safety of a new targeted therapy (DZD9008) to treat advanced recurrent Non-small Cell Lung Cancer with EGFR or HER2 mutations

Cancer type : Non-Small Cell Lung Cancer

Systemic therapy trial

A Phase I, Open-Label, Dose-Escalation Study Of The Safety And Pharmacokinetics Of...

This phase I study is trying to understand how safe, tolerable and effective a new anti-cancer drug (BLYG8824A) is in people with colorectal cancer.

Cancer type : Colorectum

Systemic therapy trial

BREAKWATER : AN OPEN-LABEL, MULTICENTER, RANDOMIZED PHASE 3 STUDY OF FIRST-LINE ENCORAFENIB PLUS...

This phase III trial is evaluating whether targeted therapy, alone or in combination with chemotherapy, is more effective than standard care in patients with metastatic colorectal (bowel) cancer

Cancer type : Colorectum

Systemic therapy trial

DREAM3R : DuRvalumab (MEDI4736) With chEmotherapy as First Line treAtment in Advanced Pleural...

This phase III trial is trying to understand whether adding a form of targeted therapy to standard chemotherapy will improve overall survival for patients with malignant pleural mesothelioma

Cancer type : Lung

Systemic therapy trial

ARTEMIDE-01 : Phase I/II, Open-label, Dose Escalation and Dose Expansion Study to Evaluate Safety,...

This phase I/II study is evaluating how safe and effective a new cancer drug (AZD2936) is in people with advanced or metastatic non-small cell lung cancer

Cancer type : Non-Small Cell Lung Cancer

Treatment trial

SEAMARK : A PHASE 2, RANDOMIZED, OPEN-LABEL STUDY OF ENCORAFENIB AND CETUXIMAB PLUS PEMBROLIZUMAB...

This phase II is evaluating the effective of combination therapy (encorafenib, cetuximab and pembrolizumab) compared to immunotherapy alone (pembrolizumab) in people with previously untreated metastatic bowel cancer

Cancer type : Colorectum

Systemic therapy trial

A Phase I-III, Multicenter Study Evaluating the Efficacy and Safety of Multiple Therapies...

This phase III study is evaluating how safe and effective different therapies (including alectinib, entrectinib, pralsetinib, and durvalumab) are in people with non-small cell lung cancer with eligible biomarker status

Cancer type : Non-Small Cell Lung Cancer

Systemic therapy trial

A Clinical Study to Demonstrate Safety and Efficacy of E7777 (Denileukin Diftitox) in...

This phase III trial is evaluating E7777 as an intravenous treatment for patients with persistant and recurrent Cutaneous T-cell Lymphoma

Cancer type : T-Cell Lymphoma

Systemic therapy trial

DREAMM 5 : A Phase I/II, Randomized, Open-label Platform Study Utilizing a Master Protocol to Study...

This phase I/II trial is testing an immunotherapy alone and in combination with other anti-cancer treatments in patients with multiple myeloma who have got worse or not responded to earlier treatment

Cancer type : Multiple Myeloma

Systemic therapy trial

M15-654 : A Phase 1/2, Multicenter, Dose-Escalation and Expansion Study of Combination Therapy With...

This phase II trial is evaluating the combination of two anti-cancer therapies (Venetoclax and Daratumumab) and a steroid (Dexamethasone), with or without (Bortezomib) chemotherapy in patients with Multiple Myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

CML13 : An Australasian Leukaemia and Lymphoma Group (ALLG) single arm phase II study to evaluate...

This trial is evaluating an oral cancer drug (asciminib) in patients with newly diagnosed chronic phase myeloid leukaemia

Cancer type : Blood

Systemic therapy trial

ALLG MM23 : An ALLG phase 3 randomised trial of Selinexor and Lenalidomide-dexamethasone versus...

This phase III trial is comparing the use of an oral cancer drug (Lenalidomide) alone and in combination with chemotherapy (Selinexor) and a corticosteroid (Dexamethasone) in patients with newly diagnosed multiple myeloma who are currently undergoing Autologous stem cell transplant

Cancer type : Multiple Myeloma

Systemic therapy trial

GRACE : An Open-Label, Multicenter, Phase I Study Evaluating the Safety and Pharmacokinetics of...

This phase I trial will evaluate different doses of a new cancer drug (RO7425781) for the treatment of multiple myeloma patients who cannot tolerate other treatment options or for whom no standard treatment is available

Cancer type : Multiple Myeloma

Systemic therapy trial

An Open-Label, Multicenter, Phase Ib Trial Evaluating the Safety, Pharmacokinetics, and...

This Phase I trial is evaluating how safe and tolerable a targeted therapy (cevostamab) is in people with relapsed or refractory multiple myelomoa

Cancer type : Multiple Myeloma

Systemic therapy trial

CRISTALLO : A Prospective, Open-Label, Multicenter Randomized Phase III Study to Compare The Efficacy...

This phase III trial is comparing the safety and effectiveness of two combinations of treatment for patients who have not yet received treatment for chronic lymphocytic leaukaemia

Cancer type : Blood

Systemic therapy trial

CARTITUDE-5 : A Phase 3 Randomized Study Comparing Bortezomib, Lenalidomide and Dexamethasone (VRd)...

This Phase III study is comparing how effective VRd induction (bortezomib, lenalidomide and dexamethasone) therapy when it is followed by either immunotherapy (cilta-cel) or a combination of lenalidomide and dexamethasone in people with newly diagnosed multiple myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

PROTAC CLL : A Phase 1, Open-Label, Dose-Escalation and -Expansion Study of the Bruton Tyrosine...

This Phase I trial is seeking to understand the recommended dose of a targeted therapy (BGB-16673) in people with B-Cell Malignancies

Cancer type : Blood

Systemic therapy trial

MOSUN : A Phase IB Open-Label, Multicenter Study Evaluating the Safety, Efficacy, and...

This phase I study is assessing how safe, tolerable and effective targeted therapy (mosunetuzumab) is in people with relapsed or refractory chronic lymphocytic leukaemia

Cancer type : Chronic Lymphocytic Leukaemia

Systemic therapy trial

KEYNOTE-C11 : Phase 2 Study of Pembrolizumab and Chemotherapy in Patients With Newly Diagnosed...

This phase II trial is evaluating how effective a treatment of immunotherapy (pembrolizumab), followed by chemotherapy, and then followed with more immunotherapy is in people with newly diagnosed classical Hodgkin lymphoma

Cancer type : Hodgkin's Disease (Hodgkin's Lymphoma)

Systemic therapy trial

Starglo : A Phase III, Open-Label, Multicenter, Randomized Study Evaluating the Efficacy and Safety...

This phase III trial aims to evaluate the effectiveness of two targeted therapy-chemotherapy combinations in patients with Diffuse Large B-cell Lymphoma

Cancer type : Blood

Systemic therapy trial

LEVERAGE : A Multicenter, Open Label, Phase Ib/II Study of Lenalidomide, Venetoclax and Obinutuzumab...

This phase 1b/2 trial is evaluating the effectiveness of two targeted therapies (venetoclax and obinutuzumab) in combination with an immunotherapy (lenaliomide) to treat follicular lymphoma

Cancer type : Follicular Lymphoma

Systemic therapy trial

NP30179 : A Multicenter, Open-Label, Phase I Study to Evaluate the Safety, Efficacy, Tolerability...

This phase I trial is trying to understand how safe and tolerable a new targeted cancer drug is for patients with B-Cell Non-Hodgkin's Lymphoma, and whether it is better given alone or in combination with another targeted cancer drug

Cancer type : Blood

Systemic therapy trial

A Phase 1/2 Dose Escalation and Cohort Expansion Study of the Safety and Efficacy of...

This phase I/II trial is evaluating a new type of immunotherapy (CTX110) in patients with B-Cell malignancies (Non-Hodgkin Lymphoma) that have got worse or not responded to prior treatment

Cancer type : Blood

Systemic therapy trial

An Open-Label, Phase I Study to Evaluate the Safety, Pharmacokinetics and Preliminary...

This phase I trial is evaluating a new targeted cancer drug in patients with Non-Hodgkin's Lymphoma who have got worse or not responded to prior treatment

Cancer type : Blood

Systemic therapy trial

BGB-3111-11417-101 : A Phase 1a/1b Open-Label Dose Escalation and Expansion Study of Bcl-2 Inhibitor BGB-11417...

This phase I trial is trying to determine the best dosing level of a targeted therapy drug (BGB-11417), and assess its effectiveness both by itself and in combination with another targeted therapy (Zanubrutinib)

Cancer type : Blood

Systemic therapy trial

COALITION : A Multicentre Trial of Frontline R-CHOP/Pola-RCHP and Glofitamab in Younger, Higher Risk...

This Phase I/II trial is trying to understand how safe and tolerable a targeted therapy drug (glofitamab) is in combination with chemotherapy in people with higher-risk Diffuse Large B-Cell Lymphoma or High Grade B-Cell Lymphoma

Cancer type : Blood

Systemic therapy trial

A Phase 1 Study of NKX019, a CD19 Chimeric Antigen Receptor Natural Killer (CAR NK) Cell...

This phase I trial is trying to understand how safe and tolerable a new targeted therapy (NKX019) is in people with relapsed or refractory non-Hodgkin lymphoma, chronic lymphocytic leukaemia or B-cell acute lymphoblastic leukaemia

Cancer type : Blood

Systemic therapy trial

A Modular Phase II, Open-label, Multicentre Study to Assess AZD4573 Efficacy and Safety...

This phase II study is assessing how safe and affective a new targeted therapy (AZD4573) is in people with either relapsed or refractory peripheral T-cell lymphoma or classical Hodgkins lymphoma

Cancer type : Blood

Systemic therapy trial

An Open-Label, Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and...

This phase I dose escalation study is seeking to determine the best dose level, safety and effectiveness of intravenous (IV) and/or subcutaneous (SC) dosing schemes of combination treatment (RO7443904, Glofitamab, Obinutuzumab and/or Tocilizumab) in people with relapsed or refractory B-cell non Hodgkin lymphoma

Cancer type : Blood

Systemic therapy trial

STAR CNS : A Phase 1b/2, Open-label Dose Escalation With Expansion Study of GB5121 in Adult Patients...

This phase I/II study is seeking to determine the safety and best dose level of a new drug (GB5121) in people with relapsed or refractory central nervous system lymphoma

Cancer type : Lymphoma

Systemic therapy trial

ALT-TRACC : Alternating oxaliplatin and irinotecan doublet schedules versus continuous doublet...

This phase II trial is comparing alternating chemotherapy and standard of care for patients whose colorectal cancer has spread to other parts of the body

Cancer type : Bowel

Systemic therapy trial

CELEBRATE : A Phase 1B Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of the...

This phase I/II trial will begin to understand how safe, well tolerated and effective a combination therapy is for the treatment of BRAF-mutant melanoma that has spread to other parts of the body

Cancer type : Melanoma (Skin)

Systemic therapy trial

CERPASS : A Randomized, Controlled, Open-Label, Phase 2 Study of Cemiplimab as a Single Agent and...

This phase II trial is assessing the benefits of using a targeted therapy (cemiplimab) in combination with a biological therapy (RP1) to treat patients with advanced or metastatic cutaneous squamous cell carcinoma

Cancer type : Cutaneous Squamous Cell Carcinoma (CSCC)

Systemic therapy trial

TROPiCS-04 : A Randomized Open-Label Phase III Study of Sacituzumab Govitecan Versus Treatment of...

This Phase III trial is evaluating the effectiveness of a targeted therapy (Sacituzumab Govitecan-hziy) compared to chemotherapy (paclitaxel, docetaxel or vinflunine) in people with bladder cancer that is unable to be treated with surgery

Cancer type : Urothelial

Systemic therapy trial

REPAIR : Phase 1 Trial of Pidnarulex and Talazoparib in Patients With Metastatic Castration...

This phase I dose-escalation study is seeking to determine the appropriate dose level of two types of targeted therapies (talazoparib and pidnarulex) in people with metastatic, castration-resistant prostate cancer

Cancer type : Prostate

Multiple treatment types

AB218 gloma (Anheart) : A Phase 0/2 Study of AB-218 in Patients With IDH1 Mutated Low Grade Glioma

This early phase I study is assessing the feasibility of treatment with targeted therapy (AB-218) prior to surgery in people with IDH1 mutated brain cancer (glioma)

Cancer type : Glioma

Systemic therapy trial

AlphaBet : Combination of Radium-223 and Lutetium-177 PSMA-I&T in Men With Metastatic...

This phase I/II study is seeking to determine the appropriate dose level of Radium-223 when given in addition to combination therapy (177Lu-PSMA-I&T) in people with metastatic, castration-resistant prostate cancer

Cancer type : Prostate

Systemic therapy trial

VIOLET : EValuation of radIOLigand Treatment in mEn With Metastatic Castration-resistant Prostate...

This phase I/II study is evaluating how safe and effective treatment with [161 Tb]Tb PSMA I&T is in men with metastatic castration-resistant prostate cancer

Cancer type : Prostate

Systemic therapy trial

Menin Umbrella : A Phase 1b Study of JNJ-75276617 in Combination With AML Directed Therapies for...

This phase I study is seeking to determine the effectiveness and appropriate dose level of a new drug (JNJ-75276617) in combination with other drugs (venetoclax and/or azacitidine) in people with acute myeloid leukaemia

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

SOLACE 2 : A Phase II randomised trial comparing immune priming by low dose oral cyclophosphamide...

This Phase II trial is comparing the effectiveness of a chemotherapy drug (Olaparib) alone and as part of a combination therapy in patients with recurrent ovarian, fallopian tube or primary peritoneal cancers that have homologous recombination repair defects

Cancer type : Female Reproductive System

Systemic therapy trial

IGNITE : A Phase II signal-seeking trial of Adavosertib (AZD1775) targeting recurrent high grade...

This phase II trial is testing an oral targeted therapy (adavosertib) in patients with high grade serous ovarian cancer

Cancer type : Ovary

Systemic therapy trial

CAMPFIRE : A Randomized, Open-Label Phase 1/2 Study Evaluating Ramucirumab in Pediatric Patients and...

This phase I/II trial is evaluating how safe and effective targeted therapy (ramucirumab) is when combined with chemotherapy (cyclophosphamide and vinorelbine), compared to chemotherapy alone, in children and young adults with desmoplastic small round cell tumours (DSRCT)

Cancer type : Soft Tissue Sarcoma

Systemic therapy trial

Keynote-C93 : A Phase 3 Randomized, Open-label, Active-comparator Controlled Clinical Study of...

This phase III trial is evaluating how safe and effective immunotherapy (pembrolizumab) compared to chemotherapy (carboplatin and paclitaxel) is in people with mismatch repair deficient (dMMR) advanced or recurrent endometrial cancer who have not had prior systemic therapy

Cancer type : Endometrium

Systemic therapy trial

SUNRISE : A Phase 2/3 Study to Evaluate the Efficacy and Safety of Unesbulin in Unresectable or...

This phase II/III study is assessing how safe and effective a new oral drug (unesbulin), compared to a placebo, is when given in combination with chemotherapy (dacarbazine) in people with inoperable, metastatic, relapsed or refractory leiomyosarcoma

Cancer type : Leiomyosarcoma

Radiotherapy trial

MASTERPLAN : A Randomised Phase II Study of MFOLFIRINOX And Stereotactic Radiotherapy (SBRT) for...

This phase II trial is trying to understand whether adding high precision radiotherapy to chemotherapy and surgery will improve treatment outcomes for patients with pancreatic cancer

Cancer type : Pancreas

Systemic therapy trial

DASL-HiCaP : Darolutamide Augments Standard Therapy for Localised Very High-Risk Cancer of the...

This phase III trial is trying to understand the effectiveness of a hormone therapy in men requiring radiation therapy for localised prostate cancer that has a high risk of coming back after treatment

Cancer type : Prostate

Radiotherapy trial

EXPERT : A Randomised Phase III Trial of Adjuvant Radiation Therapy Versus Observation Following...

This phase III trial is examining personalised radiation therapy for low-risk early breast cancer

Cancer type : Breast

Systemic therapy trial

CANTATA : A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study Comparing CB-839 in...

This phase II trial is evaluating a new oral drug (CB-839) in combination with cabozantinib (a different oral drug), compared to cabozantinib alone in patients with advanced or metastatic renal cell carcinoma

Cancer type : Urinary System

Systemic therapy trial

IPATunity150 : A phase Ib/III study of Ipatasertib plus Palbociclib and Fulvestrant versus placebo plus...

This phase Ib/III trial is examining the effectiveness and safety of using a novel targeted therapy (Ipatasertib) in combination with another targeted therapy (Palbociclib) and chemotherapy (Fulvestrant) to treat advanced unresectable or metastatic breast cancer

Cancer type : Breast

Systemic therapy trial

GO39932 : A Phase Ia/Ib, Multicenter, Open-Label, Dose Escalation, Dose Expansion Study Evaluating...

This phase I trial is evaluating the safety of an oral drug (GDC-9545) when it is given alone or in combination with other therapies (Palbociclib and/or LHRH Agonist) in patients with a ER+ breast cancer that has spread to other parts of the body

Cancer type : Breast

Systemic therapy trial

A Phase 1b Study of ZN-c3 in Combination With Chemotherapy in Patients With...

This phase I trial is trying to understand how safe, effective and well tolerated a new oral cancer drug is, in combination with chemotherapy, for the treatment of patients with ovarian, peritoneal or fallopian tube cancer

Cancer type : Female Reproductive System

Systemic therapy trial

MIRASOL : A Randomized, Open-label, Phase 3 Study of Mirvetuximab Soravtansine vs. Investigator's...

This phase III trial is comparing the safety and effectiveness of a targeted therapy and standard chemotherapy for the treatment of patients with high-grade epithelial ovarian cancer, primary peritoneal or fallopian tube cancer

Cancer type : Female Reproductive System

Systemic therapy trial

CheckMate 914 : A Phase 3 Randomized Study Comparing Nivolumab and Ipilimumab Combination vs Placebo in...

This phase III trial is trying to determine whether the combination of two immunotherapy drugs (nivolumab and ipilimumab) is effective in preventing cancer recurrence in patients with renal cell carcinoma, who have had part or all of their kidney removed

Cancer type : Urinary System

Treatment trial

An Open Label, Multi-Center, Dose Escalation/Expansion, Phase 1 Study of IMU-201...

This phase I trial is evaluating the safety and tolerability of a new type of immunotherapy, given alone or with standard of care treatment, in patients with PD-L1 non-small cell lung cancer

Cancer type : Lung

Systemic therapy trial

PAPILLON : A Randomized, Open-label Phase 3 Study of Combination Amivantamab and...

This trial aims to understand whether it is better to use a form of targeted therapy in combination with chemotherapy in the treatment of locally advanced or metastatic non-small cell lung cancer, compared to using chemotherapy alone

Cancer type : Lung

Systemic therapy trial

MAGNITUDE : A Phase 3 Randomized, Placebo-controlled, Double-blind Study of Niraparib in Combination...

This phase III trial is trying to determine how effective an oral therapy (niraparib) is in combination with a hormone therapy and a steroid (abiraterone acetate and prednisone, AA-P) in patients with metastatic prostate cancer

Cancer type : Prostate

Systemic therapy trial

CheckMate76K : A Phase 3, Randomized, Double-Blind Study of Adjuvant Immunotherapy With Nivolumab Versus...

This phase III trial will assess an adjuvant immunotherapy in children and adults who have completed surgery for Stage IIB/C melanoma and have a high risk of their cancer coming back

Cancer type : Melanoma (Skin)

Systemic therapy trial

MARIPOSA : A Phase 3, Randomized Study of Amivantamab and Lazertinib Combination Therapy Versus...

This phase III trial is trying to understand how well three targeted cancer drugs work on their own or together to treat patients with EGFR+ non-small cell lung cancers that have spread to other parts of the body

Cancer type : Non-Small Cell Lung Cancer

Systemic therapy trial

A Phase 1/2, Open-Label, Dose-Escalation Trial of GEN3013 in Patients With Relapsed,...

This phase I/II trial is trying to understand how much targeted therapy is required and if it is safe to use for the treatment of B-cell lymphoma that have got worse, not responded or come back on prior treatments

Cancer type : Blood

Systemic therapy trial

An Open Label Phase Ib Dose Finding Study of BI 836880 in Combination With BI 754091 to...

This phase I trial is assessing a new targeted therapy (BI 836880 in combination with BI 754091) in patients with non-small cell lung cancer that has spread to other parts of the body and whose cancer has gotten worse on or after first line treatment

Cancer type : Lung

Systemic therapy trial

Phase 1b/2a Study Investigating ATX-101 in Combination With Platinum-based Chemotherapy...

This phase Ib/IIa trial is evaluating the safety and effectiveness of a drug designed to enhance the effectiveness of other treatments (ATX-101) when combined with platinum-based chemotherapy (carboplatin/pegylated liposomal doxorubicin [ACD]) in people with platinum-sensitive, recurrent ovarian, fallopian tube or primary peritoneal cancer

Cancer type : Female Reproductive System

Radiotherapy trial

Phase 3, Randomized, Open Label Study to Compare Ociperlimab (BGB-A1217) Plus...

This phase III study is comparing the effectiveness of different immunotherapies (ociperlimab, tislelizumab and durvalumab), combined with concurrent chemoradiation therapy, in people with previously untreated, locally advanced non-small cell lung cancer

Cancer type : Non-Small Cell Lung Cancer

Systemic therapy trial

Piccolo : A Phase 2, Single Arm Study of Mirvetuximab Soravtansine in Recurrent Platinum-Sensitive,...

This phase II trial is evaluating how safe and effective a targeted therapy (Mirvetuximab Soravtansine) in people with platinum-sensitive ovarian, primary peritoneal or fallopian tube cancers with high folate receptor-alpha (FRα) expression

Cancer type : Female Reproductive System

Systemic therapy trial

DYNAMIC-Pancreas : Circulating Tumour DNA Analysis Informing Adjuvant Chemotherapy in Early Stage Pancreatic...

This Phase II/III trial is trying to determine whether a genetic test called “circulating tumour DNA” is an effective way to decide the specific type and duration of chemotherapy patients with localised pancreatic cancer should receive post-surgery

Cancer type : Pancreas

Systemic therapy trial

DREAMM 8 : A Phase III, Multicenter, Open-Label, Randomized Study to Evaluate the Efficacy and...

This phase III trial will evaluate the safety and effectiveness of a type of immunotherapy, given in combination with chemotherapy (Arm A) or a type of targeted therapy (Arm B), in patients with multiple myeloma who have got worse or not responded to earlier treatment

Cancer type : Multiple Myeloma

Systemic therapy trial

PRESERVE 2 : A Phase 3, Randomized, Double-Blind Study of Trilaciclib or Placebo in Patients Receiving...

This phase III study is evaluating how safe and effective a targeted therapy (trilaciclib) compared to a placebo is, when given before chemotherapy (gemcitabine and carboplatin), in people with locally advanced or metastatic triple-negative breast cancer

Cancer type : Breast

Systemic therapy trial

DUO-E : A Randomised, Multicentre, Double-blind, Placebo-controlled, Phase III Study of...

This phase III trial will assess the safety and effectiveness of a targeted cancer drug, given in combination with chemotherapy and followed by maintenance therapy, in patients with advanced or recurrent endometrial cancer

Cancer type : Female Reproductive System

Systemic therapy trial

Dynamic-Rectal : Circulating Tumour DNA Analysis Informing Adjuvant Chemotherapy in Locally Advanced...

This trial is evaluating the process of using tumour-derived DNA (ctDNA) results as a way of tailoring treatment (in this case, chemotherapy) for patients with locally advanced rectal cancer

Cancer type : Rectum

Systemic therapy trial

A Phase I/II, Open-Label, Multicenter Study Evaluating the Safety, Tolerability,...

This trial is trying to understand how safe and well tolerated a new form of targeted therapy is, in people with B-Cell Non-Hodgkin Lymphoma or Chronic Lymphocytic Leukaemia that has got worse or not responded to previous treatment

Cancer type : Blood

Systemic therapy trial

UNiCAB : A Phase II of Single Agent Cabozantinib in Patients With Locally Advanced or Metastatic...

This phase II trial is using an oral drug (Cabozantinib) to treat patients with locally advanced or metastatic clear cell renal cell carcinoma who have previously received or are unable to receive immunotherapy

Cancer type : Urinary System

Systemic therapy trial

A Phase 1b/2, Open-Label Trial to Assess the Safety and Preliminary Efficacy of...

This phase I/II trial is trying to understand how safe and tolerable a targeted therapy drug (epcoritamab) is when combined with standard of care treatments, including chemotherapy, steroids and other targeted therapy drugs, in people with B-cell Non-Hodgkin Lymphoma

Cancer type : Blood

Systemic therapy trial

SHERLOCK : Phase 2 trial of sotorasib in combination with carboplatin-pemetrexed and...

This phase II study is testing the effectiveness of a new treatment combination (sotorasib, carboplatin-pemetrexed, and bevacizumab-biosimilar) for people with non-small cell lung cancer whose cancer has a specific type of gene mutation called KRAS G12C

Cancer type : Non-Small Cell Lung Cancer

Multiple treatment types

The RaDD study : Phase I Dose Escalation Study of Radiotherapy and Durvalumab in Relapsed/Refractory...

This phase I trial is assessing simultaneous radiotherapy and immunotherapy (with durvalumab) in patients with relapsed Diffuse Large B Cell Lymphoma

Cancer type : Blood

Multiple treatment types

FLUORO : Frontline Treatment of Follicular Lymphoma With AtezolizUmab and Obinutuzumab With and...

This Phase II trial is trying to understand the effect of chemotherapy (obinutuzumab and atezolizumab) with or without radiotherapy in people with advanced follicular lymphoma

Cancer type : Follicular Lymphoma

Systemic therapy trial

Phase I, Open Label, Non-randomised, Non-comparative, Multi-center Study, Evaluating...

This phase I trial will assess how safe and tolerable a new intravenous cancer treatment is in Acute Myeloid Leukaemia, Non-Hodgkin Lymphoma, Multiple Myeloma and Chronic Lymphocytic Leukaemia patients who have not responded to prior treatment for their cancer

Cancer type : Blood

Systemic therapy trial

A Phase I, Open-label, Multicenter, Study of WVT078 in Subjects With Relapsed and/or...

This phase I trial is trying to find a safe and tolerable dose of a new intravenous treatment for multiple myeloma patients who have not responded to prior treatment

Cancer type : Multiple Myeloma

Systemic therapy trial

A Randomized, Double-blind, Placebo-controlled Phase 3 Study of Pembrolizumab (MK-3475)...

This phase III trial is evaluating the survival benefit from using concurrent chemoradiation with and without targeted therapy for the treatment of small cell lung cancer

Cancer type : Lung

Systemic therapy trial

ASCENT-03 : A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan Versus Treatment of...

This phase III study is comparing the effectiveness of targeted therapy (sacituzumab govitecan-hziy) with the physician's choice of chemotherapy (paclitaxel, nab-paclitaxel, or gemcitabine + carboplatin) in people with advanced or metastatic triple-negative breast cancer

Cancer type : Breast

Systemic therapy trial

ASCENT-04 : A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan and Pembrolizumab Versus...

This phase III study is comparing the effectiveness of a combined treatment of targeted therapy (sacituzumab govitecan-hziy) and immunotherapy (pembrolizumab), with a combined treatment of immunotherapy (pembrolizumab) and the physician's choice of chemotherapy (paclitaxel, nab-paclitaxel, or gemcitabine + carboplatin) in people with advanced or metastatic triple negative breast cancer that expresses programmed cell death ligand 1 (PD-L1)

Cancer type : Breast

Systemic therapy trial

TRANSFORM-1 : A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study Of Navitoclax In...

This phase III trial is testing the combination of two targeted cancer drugs (Ruxolitinib and Navitoclax) to see if it is better than using one targeted cancer drug (Ruxolitinib) to treat people with myelofibrosis

Cancer type : Blood

Systemic therapy trial

ENHANCE-3 : A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and...

This phase III study is trying to understand the effectiveness of immunotherapy (magrolimab) versus placebo, in combination with targeted therapy and chemotherapy (venetoclax and azacitidine) in people with newly diagnosed, previously untreated acute myeloid leukaemia

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or...

This trial aims to analyses the use of tumour suppressing medication in children with relapsed or refractory tumours or synovial sarcoma

Cancer type : Sarcoma

Systemic therapy trial

A Phase 2 Study of Magrolimab Combination Therapy in Patients With Head and Neck Squamous...

This phase II study is assessing how safe and effective different combinations of immunotherapy (magrolimab, pembrolizumab, and zimberelimab) is, with or without chemotherapy (5-FU + platinum chemotherapy, or docetaxel) in people with head and neck squamous cell carcinoma

Cancer type : Head and neck

Systemic therapy trial

HERTHENA-Lung02 : A Phase 3, Randomized, Open-label Study of Patritumab Deruxtecan Versus Platinum-based...

This phase III study is comparing the effectiveness of immunotherapy (patritumab deruxtecan) with chemotherapy in people with metastatic or locally advanced non-small cell lung cancer with EGFR-activating mutation

Cancer type : Non-Small Cell Lung Cancer

Systemic therapy trial

PETRANHA : A Multi-arm, Open-label Phase I/IIa Study to Assess the Safety, Tolerability,...

This phase I/II study is evaluating how safe and effective a new targeted therapy (AZD5305) when given in combination with new hormonal agents (enzalutamide, abiraterone acetate or darolutamide) in people with metastatic prostate cancer

Cancer type : Prostate

Systemic therapy trial

CAVEAT : A phase Ib clinical evaluation of Venetoclax in combination with chemotherapy in older...

This phase I trial is evaluating the investigational drug, venetoclax, in combination with chemotherapy for the treatment of Acute Myeloid Leukaemia (AML)

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

A Randomized, Phase 3, Open Label Study Evaluating Subcutaneous Versus Intravenous...

This phase III study is evaluating different methods of administered targeted therapy (isatuximab) when given in additional to combination therapy (pomalidomide and dexamethasone) in people with relapsed or refractory multiple myeloma who have had previous treatment

Cancer type : Multiple Myeloma

Systemic therapy trial

NADOM : Neoadjuvant/Adjuvant Trial of Darovasertib in Ocular Melanoma

This phase II study is evaluating how effective targeted therapy (darovasertib) is people with occular (uveal) melanoma who are planned to undergo surgery

Cancer type : Melanoma (Ocular)

Systemic therapy trial

KRYSTAL-10 : A Randomized Phase 3 Study of MRTX849 in Combination With Cetuximab Versus Chemotherapy...

This phase III study is evaluating whether a combination of targeted therapies (MRTX849 and Cetuximab) is more effective than chemotherapy (mFOLFOX6 or FOLFIRI regimens) in people with advanced or metastatic colorectal cancer with KRAS G12c mutations who have had previous treatment

Cancer type : Colorectum

Systemic therapy trial

A Phase 2, Randomized, Open-Label Study Evaluating the Safety and Efficacy of Magrolimab...

This phase II study is seeking to determine how safe and tolerable, and what the best dose level is, of targeted therapy (magrolimab) in addition to further targeted therapy (bevacizumab) plus combination chemotherapy (FOLFIRI) in people with advanced, metastatic bowel cancer who have had previous treatment

Cancer type : Bowel

Multiple treatment types

DECREASE : Darolutamide + Consolidation Radiotherapy in Advanced Prostate Cancer Detected by PSMA

This phase II trial is investigating the use of local consolidation radiotherapy in men with non-metastatic, castrate resistant prostate cancer

Cancer type : Prostate

Systemic therapy trial

EV-302 : An Open-label, Randomized, Controlled Phase 3 Study of Enfortumab Vedotin in Combination...

This phase III trial is trying to understand how well two targeted cancer drugs (enfortumab vedotin and pembrolizumab) work together to treat patients with urothelial cancer, compared to standard of care chemotherapy

Cancer type : Urothelial

Systemic therapy trial

A Phase 3, Randomized, Double-Blind Study of MK-7684A in Combination With Etoposide and...

This phase III study is comparing the effectiveness of two types of immunotherapy treatments (MK-7684A and atezolizumab) when used in combination with chemotherapy (etoposide and carboplatin or cisplatin) in people with Extensive-Stage Small Cell Lung Cancer

Cancer type : Small Cell Lung Cancer

Systemic therapy trial

EVOKE-02 : An Open-label, Multicenter, Phase 2 Study of Sacituzumab Govitecan Combinations in...

This phase II study is seeking to determine the appropriate dose level, safety and effectiveness of targeted therapy (Sacituzumab Govitecan-hziy) in combination with immunotherapy (pembrolizumab) or in combination with immunotherapy and chemotherapy (pembrolizumab, carboplatin and/or cisplatin) in people with advanced or metastatic non-small cell lung cancer

Cancer type : Non-Small Cell Lung Cancer

Systemic therapy trial

LIBRETTO-432 : LIBRETTO-432: A Placebo-controlled Double-Blinded Randomized Phase 3 Study of Adjuvant...

This phase III trial is trying to determine whether a new targeted cancer drug (selpercatinib) can safely and effectively delay non-small cell lung cancers from returning in non-small cell lung cancer patients who have already received surgery or radiation

Cancer type : Lung

Systemic therapy trial

MAGNETISMM-5 : AN OPEN-LABEL, 3-ARM, MULTICENTER, RANDOMIZED PHASE 3 STUDY TO EVALUATE THE EFFICACY AND...

This phase III study is trying to understand how safe and effective a targeted therapy (elranatamab) is alone, or in combination with another targeted therapy (daratumumab), compared to combination therapy (daratumumab, pomalidomide and dexamethasone) in people with multiple myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

DREAMM 3 : A Phase III, Open-Label, Randomized Study to Evaluate the Efficacy and Safety of Single...

This phase III trial is comparing the safety and effectiveness of a single drug treatment (belantamab mafodotin or blenrep) and a chemotherapy (pomalidomide plus low dose dexamethasone) for the treatment of patients with relapsed or refractory multiple myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

ASCOLT : Aspirin for Dukes C and High Risk Dukes B Colorectal Cancers - An International,...

This phase III trial is investigating asprin for Dukes C and high risk Dukes B colorectal cancers

Cancer type : Bowel

Systemic therapy trial

SYMPATICO : Phase 3 Study of Ibrutinib in Combination With Venetoclax in Subjects With Mantle Cell...

This phase III trial is combining two oral drugs (Ibrutinib and Venetoclax) for the treatment of Mantle Cell Lymphoma

Cancer type : Mantle Cell Lymphoma

Systemic therapy trial

DYNAMIC-III : Circulating Tumour DNA Analysis Informing Adjuvant Chemotherapy in Stage III Colon...

This phase II/III trial is evaluating the process of using ctDNA (tumour-derived DNA) results as a way to tailor treatment (in this case chemotherapy) in patients with stage III colon cancer

Cancer type : Bowel

Multiple treatment types

RESOLUTE : Randomised Phase II Trial to Evaluate Progression-Free Survival in Integrating Local...

This study is assessing the benefit of using a type of local ablative therapy (which could include surgery or radiation therapy) on top of standard of care treatment for people with colorectal cancer

Cancer type : Bowel

Multiple treatment types

DEBIO-1143 : A Randomized, Double-Blind Placebo-Controlled, Phase 3 Study of Debio 1143 in Combination...

This phase III trial is trying to demonstrate the benefits of adding the oral drug, Debio 1143, to chemoradiotherapy (CRT) treatment in patients with locally advanced squamous cell carcinoma of the head and neck

Cancer type : Head and Neck

Systemic therapy trial

FIDES-03 : A Phase 1b/2 Study of Derazantinib as Monotherapy and Combination Therapy With...

This Phase I/II trial is trying to understand whether it is better to use a certain type of targeted therapy (derazantinib) alone or in combination with other types of therapy in patients with stomach or gastro-oesophageal cancer

Cancer type : Stomach

Systemic therapy trial

CHARLI : A Phase Ib/II Trial of Ipilimumab-Nivolumab-Denosumab and Nivolumab-Denosumab in Patients...

This phase I/II trial is evaluating the addition of a new treatment (Denosumab) to standard immunotherapies for patients with metastatic melanoma

Cancer type : Melanoma (Skin)

Systemic therapy trial

EVX-02-001 : A Phase 1/2, Study of Adjuvant Immunotherapy With EVX-02 and Anti-PD-1 After Complete...

This phase I/IIb trial is trying to understand whether an adjuvant immunotherapy is safe, tolerable and effective for patients who have had a stage III or stage IV melanoma removed, but are at high risk of it coming back

Cancer type : Melanoma (Skin)

Systemic therapy trial

A Randomized, Placebo-Controlled, Double-Blind Study of Adjuvant Cemiplimab Versus...

This phase III trial is comparing survival outcomes for patients with high-risk cutaneous squamous cell carcinoma who are treated with adjuvant immunotherapy (cemiplimab), compared to those who are treated with a placebo, after surgery and radiotherapy

Cancer type : Skin

Systemic therapy trial

LIBRETTO-531 : A Multicenter, Randomized, Open-label, Phase 3 Trial Comparing Selpercatinib to...

This phase III trial is trying determine whether the targeted therapy (Selpercatinib) is safe and more effective than current standard targeted therapies (Cabozantinib or Vandetanib) in patients with advanced thyroid cancer

Cancer type : Head and Neck

Radiotherapy trial

ABC-X : A phase II, open-label, randomised, controlled trial of Ipilimumab and Nivolumab with...

This phase II trial is evaluating the effectiveness of using two targeted therapies (ipilimumab and nivolumab) in combination with intracranial stereotactic radiotherapy to treat melanoma brain metastases

Cancer type : Brain

Systemic therapy trial

MORPHEUS YO39609 : A Phase Ib/II, Open-Label, Multicenter, Randomized, Umbrella Study Evaluating the...

This phase I/II trial is assessing how safe and tolerable a variety of immunotherapy-based treatment combinations are in people with locally advanced unresectable or metastatic gastric or gastroesophageal junction cancer, or esophageal cancer

Cancer type : Stomach

Multiple treatment types

GoTHAM : A Phase Ib/II Study of Combination Avelumab With Peptide Receptor Radionuclide Therapy or...

This phase I/II trial is evaluating the safety and effectiveness of an immunotherapy combined with a type of radionuclide therapy or external beam radiation therapy in patients with Merkel Cell Carcinoma that has spread to other parts of the body

Cancer type : Merkel cell

Systemic therapy trial

daNIS-1 : A Phase II, Open Label, Randomized, Parallel Arm Study of NIS793 (With and Without...

This phase II trial is trying to understand how safe and effective a targeted therapy drug (NIS793) is with and without another targeted therapy drug (spartalizumab) in combination with chemotherapy (gemcitabine/nab-paclitaxel), compared with chemotherapy alone in people with untreated metastatic pancreatic ductal cancer

Cancer type : Pancreas

Systemic therapy trial

I-MAT : A Randomised, Placebo-controlled, Phase II Trial of Adjuvant Avelumab in Patients With...

This phase II trial is evaluating how effective and well tolerated an an adjuvant immunotherapy is in patients with stage I-III Merkel Cell Carcinoma

Cancer type : Merkel cell

Systemic therapy trial

COMMANDS : A Phase 3, Open-label, Randomized Study to Compare the Efficacy and Safety of...

This phase III trial is comparing an experimental drug with a standard therapy for the treatment of Anaemia caused by low- to intermediate- risk Myelodysplastic Syndrome

Cancer type : Blood

Systemic therapy trial

BELVA : A Phase Ib, Open-Label, Multicenter Study to Evaluate the Safety, Pharmacokinetics, and...

This phase I trial is trying to understand the safety and activity of a new targeted therapy drug (belvarafenib) by itself, and in combination with other targeted and immunotherapy drugs, in people with NRAS-mutant advanced melanoma

Cancer type : Melanoma (Skin)

Systemic therapy trial

ASPEN 03 : A Phase 2 Study of Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With...

This phase II study is trying to understand the effect of a combination of two immunotherapies (evorpacept and pembrolizumab), compared to pembrolizumab alone, in people with head and neck squamous cell carcinoma

Cancer type : Head and neck

Systemic therapy trial

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Study of...

This phase III trial is evaluating the effectiveness of targeted therapy (fuzuloparib), compared to a placebo, in combination with hormone therapy and steroids (abiraterone acetate and prednisone [AA-P]) in people with metastatic castration-resistant prostate cancer

Cancer type : Prostate

Systemic therapy trial

ASPEN 04 : A Phase 2 Study of Evorpacept (ALX148) in Combination With Pembrolizumab and Chemotherapy...

This phase II trial is trying to understand the effectiveness of immunotherapy (Pembrolizumab) and chemotherapy (Cisplatin/Carboplatin, 5FU) with or without targeted therapy (Evorpacept) in people with head and neck squamous cell carcinoma

Cancer type : Head and neck

Surgical trial

NADINA : Multicenter Phase 3 Trial Comparing Neoadjuvant Ipilimumab Plus Nivolumab Versus Standard...

This phase III study is evaluating the effectiveness of immunotherapy (ipilimumab and nivolumab) followed by the surgical removal of lymph nodes, compared to the standard upfront removal of lymph nodes followed by immunotherapy (nivolumab alone), in people with stage III melanoma

Cancer type : Melanoma (Skin)

Systemic therapy trial

SSGXXII : Three versus five years of adjuvant Imatinib as treatment for patients with operable...

This phase III study is comparing the effects of 3 years versus 5 years of treatment with a targeted cancer drug (imatinib) in people with gastrointestinal stromal tumours (GIST)

Cancer type : Gastrointestinal stromal tumors (GISTs)

Systemic therapy trial

An Open-label, Randomized, Phase 3 Clinical Trial of IO102-IO103 in Combination With...

This phase III study is evaluating how effective a new immunotherapy drug (IO102-IO103) is in combination with another immunotherapy drug (pembrolizumab), compared to pembrolizumab alone, in people with previously untreated, advanced melanoma

Cancer type : Melanoma (Skin)

Multiple treatment types

NeoCREATE : Neoadjuvant Immune-Chemo-Radiotherapy in operable oEsophageal and gastro-oesophageal...

This Phase II trial is trying to understand how safe and effective immunotherapy (avelumab) is in combination with chemotherapy (carboplatin and paclitaxel) and radiotherapy in people with operable oesophageal and gastro-oesophageal junction cancer

Cancer type : Stomach

Systemic therapy trial

Tiger : A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel,...

This phase III trial is comparing conventional-dose chemotherapy (TIP regimen) with high-dose chemotherapy plus an autologous stem cell transplant (TI-CE regimen) as initial salvage treatment for patients with germ cell tumours that have got worse or not responded to prior therapies

Cancer type : Urinary System

Radiotherapy trial

ENZA-p : A Randomised Phase II Trial Using PSMA as a Therapeutic Agent and Prognostic Indicator in...

This phase II trial is trying to understand the safety and potential impact of adding radiotherapy to standard hormone therapy in patients with castration resistant prostate cancer that has not previously been treated using chemotherapy and has spread to other parts of the body

Cancer type : Prostate

Systemic therapy trial

P3BEP : Phase 3 Accelerated BEP Trial: A randomised phase 3 trial of accelerated versus standard...

This phase III trial is tyring to determine whether an accerated two-week treatment of BEP chemotherapy is as effective as receiving the standrard three-week cycle, for patients with metastatic germ cell tumours

Cancer type : Germ cell tumour

Systemic therapy trial

THOR : A Phase 3 Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in...

This phase III trial is evaluating an oral drug (Erdafitinib) for the treatment of advanced urothelial cancer, compared to standard treatment with chemotherapy or immunotherapy agents

Cancer type : Urinary System

Systemic therapy trial

LuPARP : 177Lu-PSMA-617 Therapy and Olaparib in Patients With Metastatic Castration Resistant...

This phase I trial is evaluating the combination of an oral therapy (olaparib) and a combination therapy (177Lu-PSMA) in patients with castration resistant prostate cancer that has spread to other parts of the body and progressed on other targeted treatments

Cancer type : Prostate

Radiotherapy trial

UpFrontPSMA : A Randomised Phase 2 Study of Sequential 177Lu-PSMA617 and Docetaxel Versus Docetaxel in...

This phase II trial is comparing the safety and effectiveness of a specialised form of radiotherapy (radioligand therapy, 177Lu-PSMA-617) given in combination with chemotherapy, versus chemotherapy alone, for patients with newly diagnosed prostate cancer

Cancer type : Prostate

Systemic therapy trial

CRSPR : A Phase 1 Dose Escalation and Cohort Expansion Study of the Safety and Efficacy of...

This phase I trial will assess the safety and effectiveness of a new type of immunotherapy, known as CAR T-cell therapy, in patients with advanced renal cell carcinoma that has got worse or not responded to prior treatment

Cancer type : Urinary System

Systemic therapy trial

AMG757 (NEPC) : A Phase 1b Study Evaluating the Safety, Tolerability, Pharmacokinetics and Efficacy of...

This phase I trial seeks to understand how safe and tolerable an immunotherapy drug (AMG 757) is in people with neuroendocrine prostate cancer

Cancer type : Prostate

Systemic therapy trial

AMPLITUDE : A Phase 3 Randomized, Placebo-controlled, Double-blind Study of Niraparib in Combination...

This phase III trial is trying to determine whether adding a targeted cancer drug to hormone treatment in patients with castrate sensitive prostate cancer will result in improved survival outcomes

Cancer type : Prostate

Multiple treatment types

CYTOSHRINK : Cytoreductive Stereotactic Hypofractionated Radiotherapy With Combination...

This phase II trial is assessing the effect of adding radiotherapy (stereotactic body radiation therapy - SBRT) to the standard of care treatment immunotherapy (ipilimumab/nivolumab), compared with immunotherapy as a standard alone treatment, in people with metastatic kidney cancer

Cancer type : Renal cell carcinoma

Multiple treatment types

NAPSTER : NeoAdjuvant Pembrolizumab and STEreotactic Radiotherapy Prior to Nephrectomy for Renal...

This phase II study is evaluating the effect of immunotherapy (pembrolizumab) before treatment with radiation therapy and surgery to remove the kidney, in people with cancer of the kidney

Cancer type : Renal cell carcinoma

Systemic therapy trial

MK-renal : An Open-label, Randomized, Phase 3 Study of MK-6482 in Combination With Lenvatinib...

This Phase III trial is evaluating how safe and effective a combination of targeted therapies (belzutifan + lenvatinib) is compared with another targeted therapy (cabozantinib) is in peoplke with advanced renal cell carcinoma

Cancer type : Renal cell carcinoma

Systemic therapy trial

MAGMA : A multi-arm multi-stage, multi-centre, phase III (MAMS) platform trial that aims to...

This phase III trial is trying to understand whether to give glioblastoma patients chemotherapy as soon as possible following surgery and prior to chemoradiotherapy; and how many cycles of standard adjuvant chemotherapy to give patients after chemoradiotherapy

Cancer type : Brain and Spinal

Systemic therapy trial

A Phase 1 Open-Label Study to Assess the Safety, Pharmacokinetics, and Anti-tumor...

This phase I trial is trying to understand how safe and effective a targeted therapy (HP518) is in people with prostate cancer.

Cancer type : Prostate

Radiotherapy trial

ANZUP2001 : Phase II Study of Radionuclide 177Lu-PSMA Therapy Versus 177Lu-PSMA in Combination With...

This phase II study is trying to understand whether radiation therapy (177Lu-PSMA-617) is more safe and effective alone, or in combination with immunotherapy (ipilimumab and nivolumab), in people with metastatic, castration resistant prostate cancer

Cancer type : Prostate

Systemic therapy trial

KOMET : A Phase III, Multicentre, International Study With a Parallel, Randomised, Double-blind,...

This phase III study is trying to understand how safe and effective targeted therapy (selumetinib) is compared to placebo, in adults with neurofibromatosis 1 who have symptomatic, inoperable plexiform neurofibroma

Cancer type : Glioma

Systemic therapy trial

An Open-label, Multicenter, Phase I Study Evaluating the Safety, Tolerability,...

This phase I study is evaluating how safe and effective a new cancer drug (RO7428731) is in people with newly diagnosed or recurrent glioblastoma

Cancer type : Glioblastoma (GBM)

Systemic therapy trial

TiNT : A phase II study of trametinib in paediatric, adolescent and young adult patients with...

This phase II trial is evaluating the effectiveness of a targeted therapy (trametinib) in children, teenagers and young adults with neurofibromatosis type 1 (NF1) associated Plexiform Neurofibromas and Optic Pathway Gliomas

Cancer type : Glioma

Multiple treatment types

LuCAB : Cabazitaxel in Combination With 177Lu-PSMA-617 in Metastatic Castration-resistant...

This phase I/II study is evaluating how safe and effective chemotherapy (cabazitaxel) is in combination with radiation-based treatment (177Lu-PSMA-617) in people with metastatic castration-resistant prostate cancer

Cancer type : Prostate

Multiple treatment types

KEYNOTE-A18 : A Randomized, Phase 3, Double-Blind Study of Chemoradiotherapy With or Without...

This phase III trial is evaluating the safety and effectiveness of using chemo-radiotherapy with or without immunotherapy for the treatment of patients with locally advanced cervical cancer

Cancer type : Cervix

Systemic therapy trial

BEACON : A Phase II Study of Bevacizumab, Atezolizumab and Cobimetinib in Targeting the C1 Subtype...

This phase II trial is evaluating the combination of three immunotherapy drugs (Atezolizumab, Bevacizumab and Cobimetinib) in patients diagnosed with High Grade Serous Ovarian Cancer, Fallopian Tube Cancer and Primary Peritoneal Cancer

Cancer type : Female Reproductive System

Systemic therapy trial

CUPISCO : A Phase II, Randomized, Active-Controlled, Multi-Center Study Comparing the Efficacy and...

This phase II trial is comparing molecular-guided therapy with standard platinum-containing chemotherapy for the treatment of advanced cancers of the unknown primary (CUP)

Cancer type : Cancer of Unknown Primary

Systemic therapy trial

rEEcur : International Randomised Controlled Trial of Chemotherapy for the Treatment of Recurrent...

This phase II/III trial is comparing four widely used chemotherapy regimens for patients with primary refractory and recurrent Ewing Sarcoma

Cancer type : Sarcoma

Systemic therapy trial

ICON9 : International Phase III Randomised Study to Evaluate the Efficacy of Maintenance Therapy...

This phase III trial is comparing maintenance therapy with two oral drugs (Olaparib and Cediranib), versus Olaparib as a maintenance therapy alone, in patients with relapsed ovarian cancer

Cancer type : Female Reproductive System

Systemic therapy trial

REGN4018 : A Phase 1/2 Study of REGN4018 (A MUC16xCD3 Bispecific Antibody) Administered Alone or in...

This phase I/II trial is trying to understand how safe a type of targeted drug therapy is in order to determine an appropriate amount to use alone or in combination with other drugs in the treatment of recurrent ovarian, fallopian tube or primary peritoneal cancer

Cancer type : Female Reproductive System

Surgical trial

STRASS2 : A Randomized Phase III Study of Neoadjuvant Chemotherapy Followed by Surgery Versus...

This phase III study is trying to determine whether having chemotherapy before surgery is more effective than surgery alone in people with dedifferentiated liposarcoma and leiomyosarcoma

Cancer type : Sarcoma

Radiotherapy trial

ADELE : The effect of adjuvant tislelizumab plus chemotherapy on failure free survival after...

This phase II study is evaluating the effectiveness of pelvic chemoradiation therapy, followed by chemotherapy (carboplatin and paclitaxel), with or without immunotherapy (tislelizumab), in people with endometrial cancer who have had surgery

Cancer type : Endometrium

Surgical trial

HyNOVA : The safety of hyperthermic and normothermic intraperitoneal chemotherapy following...

This phase II study is investigating how safe and effective it is to administer heated (42 degrees Celsius) versus normal temperature (37 degrees Celsius) chemotherapy during surgery for people with epithelial ovarian, fallopian tube or peritoneal cancer

Cancer type : Female Reproductive System

Systemic therapy trial

Brightline 1 : Brightline-1: A Phase II/III, Randomized, Open-label, Multi-center Study of BI 907828...

This phase II/III study is comparing the effectiveness of a new medicine (BI 907828) with chemotherapy (doxorubicin) in people with dedifferentiated liposarcoma

Cancer type : Liposarcoma

Systemic therapy trial

MoST Addendum 17 (substudies 38-39) : A single arm, open label, signal-seeking, phase II trial of tepotinib in patients with...

This Phase II trial is trying to understand the effect of targeted therapy (tepotinib) in people with advanced non-small cell lung cancer.

Cancer type : Non-Small Cell Lung Cancer

Systemic therapy trial

EQUATOR : A Phase 3, Randomized, Double-Blind, Placebo-Controlled Multicenter Study of Itolizumab...

This phase III study is evaluating how safe and effective targeted therapy (itolizumab) is, compared to a placebo, in people with acute graft versus host disease

Cancer type : Graft versus Host disease

Systemic therapy trial

PACIFIC-9 : A Phase III, Double-blind, Placebo-controlled, Randomised, Multicentre, International...

This phase III trial is testing different combinations of targeted therapy in people with locally advanced non-small cell lung cancer that has not progressed on prior chemoradiotherapy treatment and is unable to be surgically removed

Cancer type : Lung

Systemic therapy trial

CYCLONE 3 : CYCLONE 3: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Abemaciclib...

This phase III study is trying to determine whether adding targeted therapy (abemaciclib) to hormone therapy (abiraterone) in combination with steroids (prednisolone or prednisone) prolongs the time before prostate cancer gets worse

Cancer type : Prostate

Systemic therapy trial

DESTINY-Lung03 : A Phase Ib Multicenter, Open-label Dose-escalation Study to Evaluate the Safety and...

This phase I study is investigating how safe, tolerable and effective targeted therapy (trastuzumab deruxtecan) is alone, and in combination with immunotherapy (durvalumab) and chemotherapy (cisplatin, carboplatin or pemetrexed) in people with HER2-positive, advanced or metastatic, non-small cell lung cancer

Cancer type : Non-Small Cell Lung Cancer

Systemic therapy trial

VICTORY : The VICTORY Study: A Phase I Study of Venetoclax in Combination With Non-myeloablative...

This phase I study is assessing the safety and appropriate dose level of targeted therapy (venetoclax) before treatment with chemotherapy drugs (fludarabine and cyclophosphamide) in people with certain blood cancers or disorders who are planned to undergo allogenic haematopoietic stem cell transplantation

Cancer type : Blood

Systemic therapy trial

An Open-label, First-in-human, Dose-escalation Study of SAR443579 Administered as Single...

This phase I/II study is evaluating how safe and effective a new targeted therapy (SAR443579) is in people with relapsed or refractory acute myeloid leukaemia, B-cell acute lymphoblastic leukaemia, or high-risk myelodysplasia

Cancer type : Blood

Systemic therapy trial

NIMBLE-AZD0466 : A Modular Phase I/II, Open-Label, Multi-Centre Study to Assess the Safety, Tolerability,...

This phase I/II study is evaluating how safe, tolerable and effective a new targeted therapy (AZD0466) is in people with blood cancers, and to also assess the interaction it has with an antifungal drug voriconazole

Cancer type : Blood

Systemic therapy trial

AUGMENT-101 : A Phase 1/2, Open-label, Dose-Escalation and Dose-Expansion Cohort Study of SNDX-5613 in...

This phase I/II study is assessing the best dose level, safety and effectiveness of a new drug (SNDX-5613) in people with acute leukaemia

Cancer type : Blood

Systemic therapy trial

Golden Gate Study : Phase 3 Randomized, Controlled Study of Blinatumomab Alternating With Low-intensity...

This phase III study is comparing a combined treatment of targeted therapy (blinatumomab) and low-intensity chemotherapy to standard of care chemotherapy in older adults with newly diagnosed Philadelphia-negative B-cell precursor Acute Lymphoblastic Leukaemia

Cancer type : Acute Lymphoblastic Lymphoma

Systemic therapy trial

HOVON 156 AML : A Phase 3, Multicenter, Open-label, Randomized, Study of Gilteritinib Versus Midostaurin...

This Phase III trial is evaluating which targeted therapy (Midostaurin or Gilteritinib) is more effective when combined with chemotherapy for people with newly diagnosed Acute Myeloid Leukaemia (AML) or Myelodysplastic Syndromes With Excess Blasts-2

Cancer type : Blood

Systemic therapy trial

Phase I/II, International, Multicentre, Open-label, Non-randomised, Non-comparative,...

This Phase I/II trial is evaluating an targeted therapy drug (S64315) in combination with another cancer drug (azacitdine) in people with Acute Myeloid Leukaemia

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

A Phase 2, Open-Label, Ascending Dose Study of KER-050 for the Treatment of Anemia in...

This phase II trial is evaluating the effects of a new drug on anemia, in patients who have very low, low or intermediate risk Myelodysplastic Syndromes (MDS)

Cancer type : Blood

Systemic therapy trial

An Open-Label, Multi-Center, Phase I Study to Evaluate the Safety, Tolerability,...

This phase I trial is trying to understand how safe and tolerable a new intravenous cancer drug (RO7283420) is for the treatment of Acute Myeloid Leukaemia (AML)

Cancer type : Blood

Systemic therapy trial

The DIAAMOND-Ava NEXT Trial : Avatrombopag iN Relapsed or Refractory severe Aplastic Anaemia as EXtra Therapy – a...

In this phase II trial, patients with severe aplastic anaemia who have been treated with, but not responded to immunosuppressive therapy (IST), will receive a new drug (avatrombopag) as a potential treatment for their condition

Cancer type : Aplastic Anaemia

Systemic therapy trial

AMLM25 : An ALLG Phase 2 study to Investigate Novel Triplets to Extend Remission with VENetoclax...

This phase II trial is investigating different chemotherapy combinations for the treatment of elderly patients that have Acute Myeloid Leukaemia

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

AMLM23 : A placebo controlled study to compare ivosidenib or enasidenib in patients with newly...

This phase III trial is investigating the safety and effectiveness of two types of targeted therapy in patients with acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS)

Cancer type : Blood

Systemic therapy trial

VIALE-T : A Randomized, Open Label Phase 3 Study Evaluating Safety and Efficacy of Venetoclax in...

This phase III study is evaluating how effective a combined treatment of targeted therapy (venetoclax and azacitidine) is, compared to best supportive care, to improve outcomes in people with Acute Myeloid Leukaemia who have had an allogenic stem cell transplant

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

An Adaptive, Open-Label, Dose-Finding, Phase 1/2 Study Investigating the Safety,...

This phase I/II trial is trying to understand the safety and effectiveness of a targeted therapy (PRN1008) in people with relapsed Immune Thrombocytopenia

Cancer type : Essential Thrombocytosis

Systemic therapy trial

A Phase 1 Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With...

This Phase I trial is seeking to determine the recommended dose level, safety and effectiveness of a targeted therapy (LY3410738) in people with IDH-mutant advanced blood cancers (including acute myeloid leukaemia, myelodysplastic syndrome, chronic myelomonocytic leukaemia and myeloproliferative neoplasms) who have previously received standard therapy

Cancer type : Blood

Systemic therapy trial

CAST : Study of using Cyclophosphamide After Sibling-donor allogeneic stem-cell Transplantation...

This phase III trial is trying to determine whether a chemotherapy drug (Cyclophosphamide) is better than the current standard of care at preventing graft versus host disease in patients that have recently received a bone marrow transplant

Cancer type : Blood

Systemic therapy trial

A Phase 1 First-In-Human Study Evaluating the Safety, Tolerability, Pharmacokinetics,...

This phase I trial is trying to determine the recommended dose of a new intravenous therapy (AMG 427) in patients with Acute Myeloid Leukaemia that has got worse or not responded to prior therapies

Cancer type : Blood

Systemic therapy trial

An International Phase Ib Multicentre Study to Characterize the Safety and Tolerability...

This phase I trial is evaluating the combination of a new intravenous drug (S64315) and an oral chemotherapy drug (venetoclax) in patients with Acute Myeloid Leuakemia (AML)

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

CT803 : A Phase 1 First in Human Study Evaluating the Safety, Tolerability, Pharmacokinetics and...

This phase I trial is evaluating an investigational drug (AMG 176) in patients with Multiple Myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

VenLDAC : A phase 2 study of venetoclax in combination with low-dose cytarabine in relapsing acute...

This phase II trial will combine two types of chemotherapy (venetoclax and cytarabine) for the treatment of acute myeloid leukaemia that has not responded or gotten worse with prior therapies

Cancer type : Blood

Systemic therapy trial

ALL09 : Phase II Study of Blinatumomab as Induction Therapy in Adolescent and Young Adult Acute...

This phase II trial is trying to determine if a new immunotherapy (Blinatumomab) can help treat patients with Acute Lymphoblastic Leukaemia

Cancer type : Acute Lymphoblastic Leukaemia

Systemic therapy trial

WUCART : A Phase 1/2 Dose-Escalation and Dose-Expansion Study of the Safety and Efficacy of...

This phase I/II study is evaluating the safety, recommended dose level, and effectiveness of a new treatment (WU-CART-007) in people with relapsed or refractory T-cell acute lymphoblastic leukaemia or lymphoblastic lymphoma

Cancer type : Blood

Systemic therapy trial

Phase I, Open Label, Multicenter, Dose Escalation Study of CD19-specific CAR-T Cells in...

This phase I trial evaluates the safety and effectiveness of engineered CAR-T cells (CD19 targeted) alone for treatment of patients with diffuse large B-cell lymphoma and in combination with targeted therapy (ibrutinib) in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma

Cancer type : Blood

Systemic therapy trial

ParadigMM-1B : A Phase 1/2 Open-label Study Evaluating the Safety, Tolerability, Pharmacokinetics,...

This phase I/II trial will be comparing different doses of the drug AMG 701 in patients with Multiple Myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

CX-5461 : A Phase 1, Open-Label, Dose Escalation, Safety, Pharmacokinetic, and Pharmacodynamic...

This phase I trial is evaluating an intravenously administered drug (CX-5461) for the treatment of advanced blood cancer

Cancer type : Blood

Systemic therapy trial

frontMIND : A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Trial Comparing the...

This Phase III trial is trying to understand how safe and effective it is to combine targeted therapy (tafasitamab plus lenaliomide) with chemotherapy (R-CHOP) for the treatment of people with diffuse large B-cell lymphoma, compared to using chemotherapy (R-CHOP) alone

Cancer type : Blood

Systemic therapy trial

DB-08 : A Phase 1b Multicentre, Open-label, Modular, Dose-finding and Dose-expansion Study to...

This phase I study is trying to understand how safe and tolerable a targeted cancer drug (trastuzumab deruxtecan) is in combination with other anti-cancer drugs in people with metastatic breast cancer

Cancer type : Breast

Systemic therapy trial

BELLA : A Single Arm Phase II Trial Evaluating the Efficacy and Safety of Bevacizumab,...

This Phase II trial is trying to determine how effective using a combination of cancer drugs (carboplatin, gemcitabine, bevacizumab and atezolizumab) is in people with early relapsed triple negative breast cancer

Cancer type : Breast

Systemic therapy trial

Morpheus-TNBC : A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating The Efficacy...

This phase I/II trial is evaluating various immunotherapy based treatment combinations as a way of treating patients with a Triple Negative Breast Cancer (TNBC) that has spread to other parts of the body

Cancer type : Breast

Systemic therapy trial

DIAmOND : An investigator-initiated, non-randomised, phase II study of combination CTLA-4 and PD-L1...

This phase II trial is trying to determine whether combining an anti-HER2 therapy (trastuzumab) with two immunotherapy drugs (durvalumab and tremelimumab) will improve clinical outcomes for patients that are diagnosed with advanced HER2+ breast cancer

Cancer type : Breast

Systemic therapy trial

WinPro : A Window of Opportunity Study of Endocrine Therapy With and Without Prometrium in...

This phase II trial is evaluating the effectiveness of delivering different combinations of hormone therapy (including letrozole, prometrium and tamoxifen) prior to surgery in postmenopausal women with early-stage breast cancer

Cancer type : Breast

Systemic therapy trial

PALVEN : A Phase 1b Study of Palbociclib, Letrozole and Venetoclax in ER and BCL-2 Positive...

This phase 1b trial is evaluating the effectiveness of combining three targeted therapies (palbociclib, letrozole and venetoclax) to treat patients with ER and BCL-2 positive locally advanced or metastatic breast cancer

Cancer type : Breast

Systemic therapy trial

CAPTURE : A phase II randomised study to evaluate alpelisib plus fulvestrant versus capecitabine in...

This phase II trial is trying to find out if treatment with a targeted cancer therapy (alpelisib) and a chemotherapy (fulvestrant) increases survival compared to a chemotherapy (capecitabine) alone in men and women with ER+, HER2- breast cancer with a PIKC3A mutation

Cancer type : Breast

Systemic therapy trial

persevERA : A Phase III Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Evaluating...

This phase III trial is comparing the safety and effectiveness of two oral hormone therapy drugs in patients with ER+, HER2- breast cancer that has spread locally or to other parts of the body

Cancer type : Breast

Systemic therapy trial

DB-07 : A Phase 1b/2 Multicentre, Open-label, Modular, Dose-finding and Dose-expansion Study to...

This phase Ib/II trial aims to explore the safety, tolerability, and anti-tumour activity of a targeted cancer therapy in patients with breast cancer that has not previously been treated using chemotherapy and has spread to other parts of the body

Cancer type : Breast

Systemic therapy trial

INAVO120 : A Phase III, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy...

This phase II/III trial is evaluating the safety and effectiveness of adding an oral targeted therapy to a standard chemotherapy/targeted therapy combination, in patients with hormone receptor positive, HER2-negative locally advanced or metastatic breast cancer

Cancer type : Breast

Systemic therapy trial

NEO-N : A randomised phase II trial evaluating the efficacy of a nivolumab monotherapy lead in...

This phase II trial is trying to understand whether using a type of immunotherapy (Nivolumab) before starting standard chemotherapy will have a different effect on reducing tumour size for patients with early stage triple negative breast cancer, compared to if the immunotherapy and chemotherapy were given at the same time

Cancer type : Breast

Systemic therapy trial

Checkmate 7FL : A Randomized, Multicenter, Double-blind, Placebo-controlled Phase 3 Study of Nivolumab...

This phase III trial is evaluating the safety and effectiveness of an immunotherapy (Nivolumab) in combination with a chemotherapy drug (Paclitaxel) in patients with ER+/HER2- breast cancer

Cancer type : Breast

Systemic therapy trial

EPIK-B3 : A Phase III, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Assess...

This phase III trial is trying to determine whether treatment with a combination of targeted therapy and chemotherapy is safe and effective for patients with advanced triple negative breast cancer

Cancer type : Breast

Systemic therapy trial

TIRHOL : A Phase 2, Multicenter, Open-Label Study of Tislelizumab (BGB-A317) in Participants With...

This phase II trial is trying to understand how effective a new targeted therapy is in Hodgkin's Lymphoma patients whose cancer has got worse or not responded to previous treatment

Cancer type : Blood

Systemic therapy trial

KATE3 : A Randomized, Multicenter, Double-Blind, Placebo-Controlled Phase III Study of the...

This Phase III trial is trying to understand the safety and effectiveness of targeted therapy (trastuzumab emtansine) in combination with immunotherapy (atezolizumab) in people with locally advanced or metastatic breast cancer

Cancer type : Breast

Systemic therapy trial

Destiny-05 : A Phase 3, Multicenter, Randomized, Open-Label, Active-Controlled Study of Trastuzumab...

This phase III trial will compare the safety and effectiveness of two targeted cancer drugs in patients with HER-2 positive, invasive breast cancer following neoadjuvant therapy

Cancer type : Breast

Systemic therapy trial

Astefania : A Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the...

This Phase III trial is evaluating how safe and effective immunotherapy (Atezolizumab) is compared with a placebo, when combined with targeted therapy (Trastuzumab Emtansine) in people with HER2-positive breast cancer

Cancer type : Breast

Systemic therapy trial

Morpheus : A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating the Efficacy...

This Phase I/II trial is evaluating how safe and tolerable a targeted cancer drug (Giredestrant) is alone, or combined with various other cancer drugs, in people with ER-positive breast cancer

Cancer type : Breast

Surgical trial

Decrescendo : De-Escalation of Adjuvant Chemotherapy in HER2-positive, Estrogen Receptor-negative,...

This phase II study is evaluating the effectiveness of chemotherapy (paclitaxel or docetaxel) combined with targeted therapy (pertuzumab and trastuzumab), followed by surgery, followed by further treatment with targeted therapy or chemotherapy, in people with HER2-positive, ER-negative, Node-negative early breast cancer

Cancer type : Breast

Systemic therapy trial

AMP945 : A Phase 1b/2a, Multicentre, Open Label Study of the Pharmacokinetics, Safety and Efficacy...

This phase I/II study is trying to determine the effectiveness of administering a targeted therapy (AMP945), prior to chemotherapy (gemcitabine and nab-paclitaxel), in people with pancreatic cancer

Cancer type : Pancreas

Systemic therapy trial

TROPION-Lung08 : A Randomized, Open-label, Phase 3 Trial of Dato-DXd Plus Pembrolizumab vs Pembrolizumab...

This trial is trying to understand how safe and effective a new targeted therapy is on its own and in combination with a standard immunotherapy (Pembrolizumab) in people with advanced non-small cell lung cancer who have not received previous treatment

Cancer type : Lung

Systemic therapy trial

RELATIVITY-123 : A Phase 3, Randomized, Open-label Study of Relatlimab-nivolumab Fixed-dose Combination...

This trial is testing two different combinations of targeted cancer treatment for people with colorectal cancer that has spread to other parts of the body

Cancer type : Colorectum

Systemic therapy trial

Efficacy of Positron Emission Tomography (PET) directed combination therapy with...

This phase II trial is evaluating how safe and effective the combination of chemotherapy (Brentuximab vedotin) and donor lymphocyte infusions is in treating people with Hodgkin lymphoma that has relapsed or persists after an allogeneic stem cell transplant

Cancer type : Hodgkin's Disease (Hodgkin's Lymphoma)

Systemic therapy trial

FORTITUDE-102 : A Phase 1b/3 Study of Bemarituzumab Plus Chemotherapy and Nivolumab Versus Chemotherapy...

This phase Ib/III study is evaluating the safety and effectiveness of targeted therapy (bemarituzumab), compared to a placebo, when combined with chemotherapy (mFOLFOX6) and immunotherapy (nivolumab) in people with previously untreated, advanced stomach and gastro-oesophageal junction cancer with FGFR2b overexpression

Cancer type : Stomach

Systemic therapy trial

HER2CLIMB-05 : A Randomized, Double-blind, Phase 3 Study of Tucatinib or Placebo in Combination With...

This phase III study is trying to understand whether targeted therapy (tucatinib) works better than placebo when given with other drugs (trastuzumab and pertuzumab) to treat people with HER2-positive breast cancer.

Cancer type : Breast

Systemic therapy trial

A Phase 1, Open-label, Dose Finding Study of CC-95251 Alone and in Combination With...

This phase I study is evaluating how safe, tolerable and effective a new targeted therapy (CC-95251) is alone, and in combination with another drug (azacitidine) in people with relapsed or refractory acute myeloid leukaemia, and people with myelodysplastic syndromes

Cancer type : Blood

Systemic therapy trial

A Phase Ib/II Open-Label, Multicenter Study Evaluating the Safety, Efficacy, and...

This phase I/II study is trying to understand how safe and effective treatment with a combination of targeted therapies (mosunetuzumab and tiragolumab), with or without immunotherapy (atezolizumab), is in people with relapsed or refractory diffuse large B-cell lymphoma or follicular lymphoma who have received some prior treatment

Cancer type : Blood

Systemic therapy trial

NEO-IMPACT : Investigating the safety and efficacy of NEO-adjuvant chemo-IMmunotherapy in PAnCreaTic...

This phase II study is trying to understand how safe and effective combining standard chemotherapy (mFOLFIRINOX) with immunotherapy (durvalumab) is in people with early stage pancreatic cancer who are considered suitable for surgery

Cancer type : Pancreas

Systemic therapy trial

Verona : A Randomized, Double-Blind, Phase 3 Study Evaluating the Safety and Efficacy of...

This phase III trial is evaluating the safety and effectiveness of a chemotherapy in combination with a cancer treatment known as Azacitidine (Vidaza) in patients with newly diagnosed higher-risk myelodysplastic syndrome

Cancer type : Myelodysplasia

Systemic therapy trial

KEYPAD : Denosumab and Pembrolizumab in Clear Cell Renal Carcinoma: a Phase II Trial

This Phase II trial is evaluating the combination of an immunotherapy (Pembrolizumab) and a targeted therapy (Denosumab) for the treatment of advanced clear cell renal cell carcinoma (ccRCC)

Cancer type : Urinary System

Systemic therapy trial

MK-6482-022 : A Multicenter, Double-blind, Randomized Phase 3 Study to Compare the Efficacy and Safety...

This phase III study is evaluating how safe and effective an oral cancer drug (belzutifan), compared with a placebo, is in combination with immunotherapy (pembrolizumab) in people with kidney cancer who have had surgery

Cancer type : Renal cell carcinoma

Systemic therapy trial

TREATT : A double blind, randomised controlled TRial EvaluAting the safety and efficacy of...

This phase III trial is trying to determine whether it is effective to give tranexamic acid (a drug that reduces heavy bleeding) to patients with Thrombocytopenia

Cancer type : Blood

Systemic therapy trial

ENHANCE-2 : A Phase 3, Randomized, Open-Label Study Evaluating the Safety and Efficacy of Magrolimab...

This phase III trial is comparing the effectiveness of three different treatments in people with previously untreated, TP53 mutant, acute myeloid leukaemia: a new targeted therapy (magrolimab) combined with a hypomethylating agent which reduces the number of abnormal blood cells (azacitidine); a different targeted therapy (venetoclax) combined with the hypomethylating agent (azacitidine); and an intensive chemotherapy regimen (including cytarabine, and daunorubicin or idarubicin)

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

CREST : A Phase 3, Multinational, Randomized, Open-Label, Three Parallel-Arm Study of...

This phase III trial is trying to understand whether it is more effective to treat patients using an immunotherapy that is injected into the bladder, with or without additional targeted therapy, in patients with high risk non-muscle invasive bladder cancer

Cancer type : Urinary System

Systemic therapy trial

EVOKE-01 : Open-Label, Global, Multicenter, Randomized, Phase 3 Study of Sacituzumab Govitecan...

This phase III trial is trying to determine whether targeted therapy (Sacituzumab Govitecan-hziy) is more effective than chemotherapy (Docetaxel) in people with advanced or metastatic non-small cell lung cancer who have had previous treatment

Cancer type : Non-Small Cell Lung Cancer

Systemic therapy trial

lidERA Breast Cancer : A Phase III, Randomized, Open-Label, Multicenter Study Evaluating the Efficacy and Safety...

This phase III trial is comparing the safety and effectiveness of a hormone therapy drug called Giredestrant with other types of hormone therapy for the treatment of stage 1-3 ER positive and HER2 negative breast cancer

Cancer type : Breast

Surgical trial

DIRECT/InspIRE Australia : Investigation of the safety and efficacy of irreversible electroporation (IRE) using the...

This study is evaluating the effectiveness of a procedure called irreversible electroporation, which uses electrical pulses to destroy cancer cells, in people with stage III pancreatic cancer who have received 3 months of chemotherapy

Cancer type : Pancreas

Radiotherapy trial

Open-label Phase 3 Study of MK-7684A (Coformulation of Vibostolimab With Pembrolizumab)...

This phase III study is evaluating whether immunotherapy (pembrolizumab/vibostolimab) in combination with chemoradiotherapy followed by further treatment with immunotherapy is more effective than treatment with chemoradiotherapy followed by a different type of immunotherapy (durvalumab), in people with non-small cell lung cancer

Cancer type : Non-Small Cell Lung Cancer

Systemic therapy trial

ASCEND : A Randomised, Double-blinded Phase II Study of Gemcitabine and Nab-Paclitaxel With CEND-1...

This phase II study is trying to understand the effectiveness of combining a new drug (CEND-1), compared to a placebo, with chemotherapy (gemcitabine and nab-paclitaxel) in people with untreated metastatic pancreatic cancer

Cancer type : Pancreas

Systemic therapy trial

KEYNOTE-C14 : A Phase II, Open-Label, Multicenter Study of Olinvacimab in Combination With...

This phase II study is evaluating how safe and effective a targeted therapy (olinvacimab) in combination with immunotherapy (pembrolizumab) is in people with metastatic triple-negative breast cancer

Cancer type : Breast

Systemic therapy trial

DYNAMIC-II : Circulating tumour DNA (ctDNA) analysis informing adjuvant chemotherapy in Stage II Colon...

This study is looking at circulating DNA and how it could inform adjuvant chemotherapy for recurrence-free survival in patient with stage II colon cancer

Cancer type : Bowel

Systemic therapy trial

TRANSFORM-2 : A Randomized, Open-Label, Phase 3 Study Evaluating Efficacy and Safety of Navitoclax in...

This phase III trial is comparing the effectiveness of two treatments (chemotherapy + immunotherapy, versus the best available therapy) in myelofibrosis patients who have got worse or not responded to previous treatment

Cancer type : Blood

Systemic therapy trial

A Phase 2, Open-Label, Multi-Center Study of Venetoclax in Combination With Carfilzomib...

This trial aims to evaluate the safety and effectiveness of a targeted cancer therapy in combination with a type of chemotherapy in multiple myeloma patients that have got worse or not responded to at least one prior treatment

Cancer type : Multiple Myeloma

Systemic therapy trial

LEAP 001 : A Phase 3 Randomized, Open-Label, Study of Pembrolizumab (MK-3475) Plus Lenvatinib...

This phase III trial is comparing an immunotherapy (Pembrolizumab) and a targeted therapy (Levatinib) with chemotherapy in patients with stage III or IV endometrial cancer, or in patients whose cancer has come back following prior treatment

Cancer type : Endometrium

Systemic therapy trial

MK-7902-017 : A Phase 3 Randomized Study of Lenvatinib in Combination With Pembrolizumab Versus...

This Phase III trial is trying to understand whether a combination of targeted therapy (Lenvatinib) and immunotherapy (Pembrolizumab) is more effective than standard care in people with metastatic colorectal cancer

Cancer type : Colorectum

Systemic therapy trial

ITHACA : A Phase 3 Randomized, Open Label, Multicenter Study of Isatuximab (SAR650984) in...

This phase III trial is trying to find the recommended dose of a targeted therapy that may benefit patients who have high-risk smouldering multiple myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

A Phase 1 Study to Evaluate the Safety and Pharmacokinetic Profiles of CB-5339 in...

This phase I trial is evaluating a targeted therapy, given orally to patients with acute myeloid leukaemia or high-risk myelodysplastic syndrome that has got worse or not responded to prior treatment

Cancer type : Blood

Systemic therapy trial

A Randomized Open-Label, Phase 3 Study to Evaluate Imetelstat (GRN163L) Versus Best...

This phase III study seeks to understand what impact a targeted therapy (Imetelstat) will have on the overall survival of people with intermediate-2 or high-risk Myelofibrosis who are not responding to other forms of treatment

Cancer type : Blood

Systemic therapy trial

A First-in-human, Phase I/II, Open-Label Study to Evaluate the Safety, Tolerability,...

This Phase I/II trial is trying to understand how safe and tolerable a new targeted therapy drug (EMB-06) is in people who have multiple myeloma that has come back or is resistant to other treatment

Cancer type : Multiple Myeloma

Systemic therapy trial

Phase 1-2 UMBRELLA Trial Evaluating Isatuximab With or Without Dexamethasone in...

This phase I/II trial has been designed to find the recommended dose of a targeted therapy drug and determine whether it is more effective than chemotherapy as treatment for multiple myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

KEYNOTE-B96 : A Phase 3, Randomized, Double-Blind Study of Pembrolizumab Versus Placebo in Combination...

This phase III trial is evaluating whether immunotherapy (pembrolizumab) versus placebo, combined with chemotherapy (paclitaxel), with or without targeted therapy (bevacizumab), is more effective in people with epithelial ovarian, fallopian tube, or primary peritoneal cancer

Cancer type : Female Reproductive System

Systemic therapy trial

I-FIRST : A Prospective, Multi-Centre Trial of TKI Redifferentiation Therapy in Patients With RAIR...

This phase II trial will use Dabrafenib and/or Trametinib to enhance treatment for people with thyroid cancer who no longer respond to radioactive iodine (a standard treatment for people with this type of cancer)

Cancer type : Thyroid

Systemic therapy trial

IRIL : A prospective Phase II study of Isatuximab Rescue for Inadequate response to Lenalidomide...

This trial is evaluating the effectiveness of a targeted therapy (Isatuximab) for patients with newly diagnosed multiple myeloma, who are unable to have a transplant and have had an inadequate response to treatment with lenalidomide and dexamethasone

Cancer type : Multiple Myeloma

Systemic therapy trial

EPIK-O : EPIK-O: A Phase III, Multi-center, Randomized (1:1), Open-label, Active-controlled, Study...

This phase III study is evaluating how safe and effective a combined treatment of targeted therapy (alpelisib) and a different cancer drug (olaparib), compared to chemotherapy (paclitaxel or pegylated liposomal doxorubicin), is in people with platinum resistant or refractory high-grade serous ovarian cancer, with no germline BRCA mutation detected

Cancer type : Ovary

Systemic therapy trial

Three Versus Five Years of Adjuvant Imatinib as Treatment of Patients With Operable GIST...

This phase III study is evaluating whether receiving targeted therapy (imatinib) for three or five years is more effective in people with gastrointestinal stromal tumours following surgery

Cancer type : Gastrointestinal stromal tumour (GIST)

Systemic therapy trial

An Open-Label, Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and...

This phase I study is trying to understand the appropriate dose level and effectiveness of a new cancer drug (RO7443904) when administered with a targeted therapy (Glofitamab) in people with relapsed or refractory B-cell non-Hodgkin's lymphoma, after they have received a different targeted therapy (obinutuzumab) as pre-treatment

Cancer type : Blood

Systemic therapy trial

A Phase 2 Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and...

This Phase II trial is evaluating how safe and effective a new drug (KER-050) is alone, and in combination with targeted therapy (ruxolitinib) in people with myelofibrosis

Cancer type : Myelofibrosis

Systemic therapy trial

A Phase 1 Dose Escalation and Expansion Open-label, Multicenter, Study of OP-1250 in...

This phase I study is trying to determine the appropriate dose level of a new targeted therapy (OP-1250) in combination with another targeted therapy (palbociclib), and to determine its effectiveness, in people with ER+/HER2- advanced or metastatic breast cancer

Cancer type : Breast

Systemic therapy trial

PORCUPINE2 : A Modular, Phase II, Open-Label, Multicentre Study to Assess the Preliminary Efficacy and...

This Phase II study is evaluating the effectiveness of a new targeted therapy (RXC004) in people with RNF43 mutation advanced or metastatic pancreatic ductal cancer or biliary tract cancer that have progressed following standard of care treatment

Cancer type : Stomach

Systemic therapy trial

FINER : A Double-Blind Placebo-Controlled Randomized Phase III Trial of Fulvestrant and...

This phase III trial is trying to find out if a new targeted therapy (Ipatasertib) can slow the growth of advanced breast cancer when added to standard hormone therapy (Fulvestrant)

Cancer type : Breast

Systemic therapy trial

MonumenTAL-2 : A Multi-arm Phase 1b Study of Talquetamab With Other Anticancer Therapies in Participants...

This phase I study is evaluating how safe and tolerable a targeted therapy (talquetamab) is when administered in different combinations with other cancer drugs (including carfilzomib, daratumumab, lenalidomide and pomalidomide) in people with multiple myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

Phase II, Open Label, Study of PHE885, a B-cell Maturation Antigen (BCMA)-Directed CAR-T...

This phase II study is trying to determine how safe and effective a new cancer drug (PHE885) is in people with relapsed and refractory multiple myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

A Phase 1b/2 Dose-Escalation and Cohort-Expansion Study to Determine the Safety and...

This phase I/II study is evaluating how safe and effective a new targeted therapy (BGB-11417) is alone, and in combination with the targeted therapy carfilzomib and the steroid dexamethasone, in people with relapsed/refractory multiple myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

A Phase 1b, Dose Escalation and Expansion Study of Lemzoparlimab With or Without...

This phase I dose escalation and expansion study is evaluating a targeted therapy (lemzoparlimab), with or without the steroid dexamethasone, in combination with other targeted therapies (pomalidomide, carfilzomib or daratumumab) in adults with multiple myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

A Phase Ib, Multi-center, Open-label Dose Escalation and Expansion Platform Study of...

This phase I study is assessing how safe, tolerable and effective a targeted therapy (VAY736) is alone, and in combination with cancer drug lenalidomide, in people with relapsed or refractory B-cell non-Hodgkin lymphoma

Cancer type : Blood

Systemic therapy trial

An Open-Label, Multicenter, Phase 1/2 Trial of GEN3014 (HexaBody®-CD38) in Relapsed or...

This phase I/II dose escalation and expansion trial is evaluating a new immunotherapy (GEN3014) in people with relapsed or refractory multiple myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

OMNIVERSE : A Phase 1B, Open-label, Global, Multicenter, Dose Determination Study to Evaluate Safety,...

This phase I study is evaluating how safe, tolerable and effective an oral drug (CC-486) is in combination with targeted therapy (venetoclax) in people with relapsed, refractory or newly diagnosed acute myeloid leukaemia

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

STIMULUS-MDS3 : A Single-arm, Open-label, Phase II Study of Sabatolimab in Combination With Azacitidine...

This phase II trial is trying to find out if a new immunotherapy (sabatolimab), when given in combination with other cancer treatments (azacitidine and venetoclax) is safe and has beneficial effects in people with high or very high risk myelodysplastic syndrome who are not suitable for treatment with intensive chemotherapy or a stem-cell transplant

Cancer type : Myelodysplasia

Systemic therapy trial

MajesTEC-2 : A Multi-arm Phase 1b Study of Teclistamab With Other Anticancer Therapies in Participants...

This phase I study is trying to understand how safe and tolerable, and determine the optimal dose level, of a targeted therapy (teclistamab) when it is administered in different combinations with other cancer drugs in people with multiple myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

A Phase Ib, Multicenter, Open-label Platform Study of Select Drug Combinations in Adult...

This phase I study is evaluating how safe and tolerable different targeted therapies (MBG453, NIS793 and canakinumab) are alone, or combined, in people with lower risk myelodysplastic syndromes.

Cancer type : Myelodysplasia

Systemic therapy trial

PACIFICA : A Randomized, Controlled Phase 3 Study of Pacritinib Versus Physician's Choice in...

This phase III trial is comparing the effectiveness of targeted therapy (pacritinib) with the physician's choice of treatment (either corticosteroids, hydroxyurea, danazol, or low-dose ruxolitinib) in people with Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-essential Thrombocythemia Myelofibrosis

Cancer type : Myelofibrosis

Systemic therapy trial

DIAAMOND-Ava FIRST : Avatrombopag plus up Front ImmunosuppReSsive Therapy in treatment-naive severe aplastic...

This phase II trial is trying to understand whether the addition of a new drug (avatrombopag) to standard immunosuppressive therapy (IST) can effectively treat patients with severe aplastic anaemia who have not had prior treatment

Cancer type : Aplastic Anaemia

Systemic therapy trial

A Phase 1a/1b Dose Escalation and Dose Expansion, First-in-human, Open-Labeled Study of...

This phase I trial is trying to determine the recommended dose level, and understand how safe and effective, a new targeted therapy (ETH-155008) is in people with relapsed or refractory B-cell Non-Hodgkin's Lymphoma, chronic lymphocytic leukaemia, small lymphocytic lymphoma and acute myeloid leukaemia

Cancer type : Blood

Systemic therapy trial

InMIND : A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate...

This Phase III trial is evaluating the effectiveness of targeted therapy (tafasitamab), compared with a placebo, is when combined with other cancer drugs (lenalidomide and rituximab) in people with relapsed or refractory follicular lymphoma or marginal zone lymphoma

Cancer type : Blood

Systemic therapy trial

A Phase 1b/2, Open-Label, Dose Finding, and Expansion Study of the Bcl-2 Inhibitor...

This Phase I/II trial is evaluating how safe, tolerable and effective a targeted therapy (BGB-11417) is when combined with azacitidine (an anti-cancer drug) in people with acute myeloid leukaemia and myelodysplastic syndrome

Cancer type : Blood

Systemic therapy trial

MAGNETISMM-3 AN OPEN-LABEL, MULTICENTER, NON-RANDOMIZED PHASE 2 STUDY OF ELRANATAMAB...

This Phase II trial is trying to understand the benefits of taking a targeted therapy (Elranatamab) alone in people with relapsed or refractory multiple myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

A Phase 1/2 Multicenter, Open-label Study to Assess the Safety, Pharmacokinetics and...

This phase I/II study is trying to understand how safe and effective a new targeted therapy (CC-92480) is when administered alone, or in combination with steroids (dexamethasone) in people with relapsed or refractory multiple myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

CC-90007-CP-004 : A Phase 1, 2-Part, Multicenter, Open-label, 3-Arm Study to Determine the Effect of...

This phase I trial is evaluating how an oral drug (Enasidenib) works on single doses of other drugs in patients with Acute Myeloid Leukaemia that have an Isocitrate Dehydrogenase 2 (IDH2) mutation

Cancer type : Blood

Systemic therapy trial

KEYNOTE-348 : A Phase 1b Open Label Study Investigating the Safety and Efficacy of Blinatumomab in...

This phase I trial is combining a new drug (blinatumomab) with a commonly used immunotherapy drug (pembrolizumab) for the treatment of relapsed or refractory Diffuse Large B-Cell Lymphoma (DLBCL)

Cancer type : Blood

Systemic therapy trial

GO29781 (BiTE) : An Open-Label, Multicenter, Phase I/IB Trial Evaluating the Safety and Pharmacokinetics...

This phase I trial is evaluating the safety and effectiveness of an investigational therapy (BTCT4465A) alone and in combination with an immunotherapy drug (Atezolizumab) in patients with B-Cell Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukaemia who have got worse or not responded to treatment

Cancer type : Blood

Systemic therapy trial

Ponatinib-3001 : A Phase 3, Randomized, Open-label, Multicenter Study Comparing Ponatinib Versus Imatinib,...

This phase III trial is comparing the effectiveness of two targeted therapies as a first line treatment for newly diagnosed Acute Lymphoblastic Leukaemia (ALL) in combination with reduced-intensity chemotherapy

Cancer type : Blood

Systemic therapy trial

CARTITUDE-4 : A Phase 3 Randomized Study Comparing JNJ-68284528, a Chimeric Antigen Receptor T Cell...

This phase III trial is comparing a type of immunotherapy, called CAR-T therapy, with two forms of standard treatment for multiple myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

ALLG MM19 : A Phase 3 trial of thalidomide-dexamethasone consolidation versus...

This phase III trial is evaluating a chemotherapy-steroid combination as maintenance therapy for transplant-eligible multiple myeloma (MM) patients who are undergoing single autologous stem cell transplantation (ASCT) as part of front-line therapy

Cancer type : Multiple Myeloma

Systemic therapy trial

EX-TEM : Phase III Trial of Extended Temozolomide in Newly Diagnosed Glioblastoma

This phase III trial is trying to determine if extended post-radiation chemotherapy will improve survival outcomes in patients with newly diagnosed glioblastoma

Cancer type : Brain and Spinal

Systemic therapy trial

REFINE : A Phase 2 Open-Label Study Evaluating Tolerability and Efficacy of Navitoclax Alone or in...

This phase II trial is trying to determine whether it is safer and more effective to use an oral targeted therapy alone or as a combination treatment for myelofibrosis

Cancer type : Blood

Systemic therapy trial

CONTACT-03 : A Phase III, Multicenter, Randomized, Open-Label Study to Evaluate the Efficacy and...

This phase III trial is evaluating the safety and effectiveness of an immunotherapy drug in combination with chemotherapy, compared to chemotherapy on its own, in patients with metastatic renal cell carcinoma

Cancer type : Urinary System

Systemic therapy trial

RELATIVITY : A Phase 2 Randomized Double-blind Study of Relatlimab Plus Nivolumab in Combination With...

This phase II trial aims to assess the safety of two types of immunotherapy (nivolumab and relatlimab) in combination with chemotherapy, to determine if it will improve survival outcomes for people with untreated Stage IV or recurrent non-small cell lung cancer, compared to using one type of immunotherapy (nivolumab) and chemotherapy for the treatment of people with this type of cancer

Cancer type : Lung

Radiotherapy trial

MASTERPLAN : MASTERPLAN: A Randomised Phase II Study of MFOLFIRINOX And Stereotactic Radiotherapy...

This phase II trial is evaluating the effectiveness and safety of chemotherapy (Mfolfirinox) and stereotactic radiotherapy in people with locally advanced pancreatic cancer

Cancer type : Pancreas

Systemic therapy trial

A Phase 3, Randomized, Open-label Study of NKTR-214 Combined With Nivolumab Versus...

This phase III trial is trying to determine how well an investigational drug (NKTR-214) works when combined with an immunotherapy drug (Nivolumab) for the treatment of previously untreated melanoma skin cancer that is either unable to be surgically removed or has spread

Cancer type : Melanoma (Skin)

Systemic therapy trial

BRUIN CLL-322 : A Phase 3 Open-Label, Randomized Study of Fixed Duration Pirtobrutinib (LOXO-305) Plus...

This phase III trial is trying to understand how safe and effective combining three types of targeted therapy (pirtobrutinib, venetoclax and rituximab) is, compared to a combination of two targeted therapies (venetoclax and rituximab) in people with chronic lymphocytic leukaemia or small lymphocytic lymphoma that have previously had treatment

Cancer type : Blood

Surgical trial

RoLaCaRT-1 : An international randomised phase II trial comparing surgical outcomes of...

The aim of this trial is to compare the use of robotic surgery with laparoscopic ('keyhole') surgery for the treatment of right sided colon cancer

Cancer type : Bowel

Systemic therapy trial

PHITT : Paediatric Hepatic International Tumour Trial

This phase III trial is evaluating and comparing different treatment programs, including chemotherapy and targeted therapy, in people with liver cancer

Cancer type : Liver

Systemic therapy trial

A Phase 1, First-in-Human, Open-Label Study of the Safety, Pharmacokinetics, and...

This phase I trial is trying to measure the dose of a new oral therapy (JNJ-67856633) as a possible treatment for people with B-Cell Non-Hodgkin Lymphoma or Chronic Lymphocytic Leukaemia, who have gotten worse or not responded to other treatments

Cancer type : Blood

Systemic therapy trial

A Phase III, Double-Blinded, Randomized, Placebo-Controlled Study of Atezolizumab Plus...

This phase III trial is trying to understand how safe and effective immunotherapy (atezolizumab) in combination with targeted therapy (cobimetinib and vemurafenib), compared to a placebo in combination with targeted therapy, is in people with previously untreated BRAFv600 mutation-positive metastatic or locally advanced melanoma

Cancer type : Melanoma (Skin)

Systemic therapy trial

A PHASE 3, RANDOMIZED, OPEN-LABEL STUDY OF LORLATINIB (PF-06463922) MONOTHERAPY VERSUS...

This phase III trial is trying to compare the effectiveness of two types of targeted therapies (Lorlatinib and Crizotinib) at prolonging the progression-free survival in people with advanced ALK-positive Non-Small Cell Lung Cancer

Cancer type : Non-Small Cell Lung Cancer

Systemic therapy trial

PLIMATH : A Multi-centre Phase II Study to Determine the Response Kinetics, Safety and Efficacy of...

This Phase II trial is evaluating the drug pembrolizumab (commonly used in immunotherapy) as a treatment for patients with newly diagnosed Hodkgin Lymphoma

Cancer type : Hodgkin's Disease (Hodgkin's Lymphoma)

Systemic therapy trial

Cardio-TTRansform : A Phase 3 Global, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the...

This phase III trial is evaluating how effective 4-weekly injections of the drug Eplontersen, compared with a placebo, is in people with Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

Cancer type : Amyloidosis

Systemic therapy trial

1st FLOR : First-line Treatment for Grade 1-3A Follicular Lymphoma Using Opdivo (Nivolumab) Plus...

This phase I trial is trying to determine whether it is safe to give the drug Nivolumab before and in combination with the drug Rituximab, in patients who have previously untreated Follicular Lymphoma

Cancer type : Follicular Lymphoma

Systemic therapy trial

BGB-3111-304 (TN CLL) : An International, Phase 3, Open-Label, Randomized Study of BGB-3111 Compared With...

This phase III trial is comparing an oral drug (BGB-3111) with a combined treatment of Bendamustine and Rituximab, in patients with previously untreated Chronic Lymphocytic Leukaemia (CLL) or Small Lymphocytic Lymphoma (SLL)

Cancer type : Blood

Systemic therapy trial

An Open-Label, Multicenter, Phase 1b/2 Study of the Safety and Efficacy of KRT-232 in...

This phase I/II trial is evaluating the effectiveness of a new targeted therapy (KRT-232) combined with another targeted therapy (acalabrutinib) in people with relapsed or refractory diffuse large B-cell lymphoma and chronic lymphocytic leukaemia

Cancer type : Blood

Systemic therapy trial

An Open-Label, Multicenter, Phase 1b/2 Study of the Safety and Efficacy of TL-895...

This phase Ib/II trial is trying to understand how safe and effective a combined treatment of two targeted therapies (TL-895 and KRT-232) is in adults with FLT3 mutated Acute Myeloid Leukaemia

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

VIALE-M : Randomized, Open-label, 2-Arm, Multicenter, Phase 3 Study of Venetoclax and Azacitidine...

This phase III trial has been designed to evaluate the addition of two cancer treatments (venetoclax in combination with azacitidine) to standard care, compared with standard care on its' own as a maintenance therapy for adult's with acute myeloid leukaemia (AML)

Cancer type : Blood

Systemic therapy trial

A Phase 2 Study to Evaluate the Efficacy and Safety of MK-1026 in Participants With...

This phase II trial is trying to understand how safe and effective a targeted therapy (nemtabrutinib) is in people with blood cancers

Cancer type : Blood

Systemic therapy trial

IsAMYP : A Phase 2, Open Label, Multicenter, Single-stage Study to Evaluate the Efficacy of...

This phase II study is trying to understand how effective a combined treatment of targeted therapy (isatuximab and pomalidomide) and steroids (dexamethasone) (IPd) is in people with AL amyloidosis

Cancer type : Amyloidosis

Systemic therapy trial

A Phase 3, Double-Blind, Multicenter Study to Evaluate the Efficacy and Safety of...

This phase III trial is trying to determine the effectiveness of a targeted therapy (CAEL-101) combined with Standard of Care treatment, compared to a placebo combined with Standard of Care treatment, in people with May stage IIIb AL Amyloidosis that have not received prior treatment

Cancer type : Amyloidosis

Systemic therapy trial

A Phase 3, Double-Blind, Multicenter Study to Evaluate the Efficacy and Safety of...

This phase III study is trying to determine the effectiveness of targeted therapy (CAEL-101) combined with the Standard of Care treatment, compared to a placebo combined with the Standard of Care treatment, in people with Mayo stage IIIa AL amyloidosis that have not received prior treatment

Cancer type : Amyloidosis

Systemic therapy trial

DREAMM 7 : DREAMM 7: A Multicenter, Open-Label, Randomized Phase III Study to Evaluate the Efficacy...

This phase III trial is comparing the safety and effectiveness of two targeted cancer therapies, given in combination with a standard cancer treatment, for patients with multiple myeloma that has got worse or come back following prior treatment

Cancer type : Multiple Myeloma

Systemic therapy trial

FREEDOM2 : A Phase 3, Multicenter, Open-label, Randomized Study to Evaluate the Efficacy and Safety...

This phase III trial is trying to determine whether a new self-administered therapy (Fedratinib) is safer and more effective than the current best available therapy in the myelofibrosis treatment

Cancer type : Myelofibrosis

Systemic therapy trial

A Phase Ib/II Open-Label Study of APG-2575 in Combination With Novel Therapeutic Regimens...

This phase I/II trial is evaluating how safe, tolerable and effective a new targeted therapy (APG-2575) is when combined with other treatment regimens (Pd or DRd) in people with relapsed or refractory multiple myeloma and immunoglobin light chain amyloidosis

Cancer type : Blood

Systemic therapy trial

VITALIZE : A Phase 2b, Open-label, Multicenter, Randomized Parallel-Group, Two-Stage, Study of an...

This phase II trial is evaluating how safe and effective a combination of immunotherapy treatments (DPX-Survivac and Pembrolizumab) is both with and without chemotherapy (cyclophosphamide) is in people with relapsed or refractory Diffuse Large B-Cell Lymphoma

Cancer type : Blood

Systemic therapy trial

An Open-label, Multi-centre, Phase I/II Study to Investigate the Safety, Tolerability,...

This Phase I/II trial is investigating the appropriate dose and effectiveness of two anticancer drugs (CN1 and CN401) in adult patients with relapsed or refractory peripheral T-cell lymphoma

Cancer type : Blood

Radiotherapy trial

AVATAR : Stereotactic Radiotherapy for Oligoprogressive ER-positive Breast Cancer

This trial is trying to understand if radiotherapy could work as an effective treatment for patients with breast cancers that have had partial response to prior treatment

Cancer type : Breast

Systemic therapy trial

DESTINY-B12 : An Open-Label, Multinational, Multicenter, Phase 3b/4 Study of Trastuzumab Deruxtecan in...

This Phase III trial is evaluating how safe and effective targeted therapy (Trastuzumab deruxtecan (T-DXd)) is in patients with advanced or metastatic HER2-positive breast cancer that has or has not spread to the brain.

Cancer type : Breast

Systemic therapy trial

M14-728 : A Phase 2 Open-Label Study of the Efficacy of Venetoclax in Subjects With Relapsed or...

This phase II trial is evaluating an oral chemotherapy drug (Venetoclax) in participants with Chronic Lymphocytic Leukaemia (CLL)

Cancer type : Chronic Lymphocytic Leukaemia

Systemic therapy trial

NMP : A Phase I, Open Label Dose Escalation Trial of Orally Administered N-methyl-pyrrolidone...

This phase I trial is evaluating an oral drug (N-methyl-pyrrolidone) in patients with relapsed Myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

CADENZA : A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy and...

This phase III trial is evaluating an investigational drug (Sutimlimab) in patients with primary cold agglutinin disease without a recent history of blood transfusion

Cancer type : Aplastic Anaemia

Systemic therapy trial

MK-4280-003 : A Phase 1/Phase 2 Clinical Study to Evaluate the Safety and Efficacy of a Combination of...

This phase I/II trial is evaluating an immunotherapy combination (MK-4280 and Pembrolizumab) in patients with Hodgkin Lymphoma, Non-Hodgkin Lymphoma or B-Cell Lymphoma

Cancer type : Blood

Systemic therapy trial

A Phase Ib, Open-Label, Multicenter Study Evaluating the Safety and Efficacy of...

This phase I trial is evaluating the safety and effectiveness of two targeted therapy drugs, each given in combination with chemotherapy for the treatment of diffuse large B-cell lymphoma (DLBCL) or high-grade B-cell lymphoma (HGBCL) that has got worse or not responded to prior treatment

Cancer type : Blood

Systemic therapy trial

M16-183 : Phase 1b Study of Venetoclax and Dinaciclib (MK7965) in Patients With Relapsed/Refractory...

This phase I trial is evaluating two drugs (one oral and one intravenous) in Acute Myeloid Leukaemia (AML) patients who have got worse or not responded to treatment

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

BGB3111_212 (FL) : An International, Phase 2, Open-Label, Randomized Study of BGB-3111 Combined With...

This phase II trial is evaluating Obinutuzumab alone and in combination with a new oral drug (BGB-3111) for the treatment of non-Hodgkin follicular lymphoma that has got worse or not responded to prior treatment

Cancer type : Follicular Lymphoma

Systemic therapy trial

MAX-40279-001 : A Phase I Trial of MAX-40279 Given Orally to Subjects With Acute Myelogenous Leukemia...

This phase I trial is testing a new oral drug (MAX-40279) for the treatment of Acute Myelogenous Leukaemia (AML)

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

BGB-3111-113 : A Drug-Drug Interaction Study of Zanubrutinib With Moderate and Strong CYP3A Inhibitors...

This phase I trial is trying to understand how the body reacts to a targeted therapy drug (zanubrutinib) with administered in combination with enzyme inhibitors (cytochrome P450 A) in people with B-Cell malignancies

Cancer type : Blood

Systemic therapy trial

KRT-232-104 : An Open-Label, Multicenter, Phase 1b/2 Study of the Safety and Efficacy of KRT-232...

This Phase I/II trial is trying determine the effectiveness of a targeted therapy drug (KRT-232) in combination with chemotherapy (cytarabine and decitabine) in people adults with acute myeloid leukaemia

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

REDIRECT : A Phase II Open-label Multicenter Study to Assess the Efficacy and Safety of AFM13 in...

This phase II trial is trying to understand the safety and effectiveness of a targeted therapy drug (AFM13) in people with CD30-positive T-cell lymphoma

Cancer type : T-Cell Lymphoma

Systemic therapy trial

STIMULUS-MDS2 : A Randomized, Double-blind, Placebo-controlled Phase III Multi-center Study of...

This Phase III trial is trying to understand the effect of a new immunotherapy (MBG453) in combination with chemotherapy (azacitidine) compared with azacitidine and a placebo in people with intermediate, high or very high risk myelodysplastic syndrome or chronic myelomonocytic leukaemia-2

Cancer type : Blood

Systemic therapy trial

KappaMab : A Phase IIb, open label, sequential cohort study comparing KappaMab alone to KappaMab in...

This phase II trial is evaluating an investigational antibody therapy (KappaMab) in combination with lenalidomide (a chemotherapy drug) and dexamethasone (a steroid) for the treatment of relapsed Multiple Myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

PETReA : Phase 3 evaluation of PET-guided, Response-Adapted therapy in patients with previously...

This phase III trial will assign patients with follicular lymphoma to a certain type of treatment using a PET-scan and assess overall outcomes associated with treatment

Cancer type : Blood

Systemic therapy trial

A Phase 3 Randomized, Open-Label, Multicenter Study Comparing Zanubrutinib (BGB-3111)...

This phase III trial is trying to understand whether it is safer and more effective to combine chemotherapy and targeted therapy for the treatment of mantle cell lymphoma, or to use targeted therapy alone, in patients who are not eligible for a stem cell transplant and have not received prior treatment

Cancer type : Blood

Systemic therapy trial

PERSPECTIVE : A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 3 Study of the Bruton's...

This phase III trial is trying to determine the benefit of adding an immunotherapy drug (Ibrutinib) to Rituximab treatment in patients who have been diagnosed with Follicular Lymphoma and not yet received treatment

Cancer type : Blood

Systemic therapy trial

EURONET-PHL-C2 : Second International Inter-Group Study for Classical Hodgkin Lymphoma in Children and...

This phase III trial is evaluating chemotherapy intensification in Hodgkin Lymphoma patients who receive less radiotherapy

Cancer type : Hodgkin's Disease (Hodgkin's Lymphoma)

Systemic therapy trial

BGB-3111 : A Phase IA, Open Label, Multiple Dose, Dose Escalation Study to Investigate the Safety...

This phase I trial is investigating a new drug (BGB3111) for the treatment of B-Cell Lymphomas

Cancer type : Blood

Systemic therapy trial

ZEAL-1L : A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Comparing...

This phase III trial is trying to improve maintenance therapy for patients with stage 3B or 4 non-small cell lung cancer who have remained stable or responded to first-line treatment. It will compare immunotherapy alone and in combination with an oral targeted therapy.

Cancer type : Lung

Systemic therapy trial

Multiple Part Clinical Trial of Brentuximab Vedotin in Classical Hodgkin Lymphoma...

This Phase II trial is evaluating how effective two different combinations of treatments including anticancer drugs, chemotherapy and immunotherapy, are at treating classical Hodgkin lymphoma

Cancer type : Hodgkin's Disease (Hodgkin's Lymphoma)

Systemic therapy trial

CheckMate73L : A Phase 3, Randomized, Open Label Study to Compare Nivolumab Plus Concurrent...

This phase 3 trial is comparing the effectiveness of concurrent chemoradiotherapy (CCRT) followed by different combinations targeted therapies (nivolumab, ipilimumab or durvalumab) for the treatment of locally advanced non-small call lung cancer

Cancer type : Non-Small Cell Lung Cancer

Systemic therapy trial

A Phase 1 Open-label, Multicenter Study Evaluating the Safety and Pharmacokinetics of...

This Phase I trial is evaluating the safety of a targeted therapy drug (IGM-2323) in people with relapsed or refractory Non-Hodgkin Lymphoma

Cancer type : Blood

Systemic therapy trial

ESCALADE : Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Acalabrutinib in...

This trial aims to assess the safety and effectiveness of combined anti-cancer treatment in patients with previously untreated diffuse large B-cell lymphoma

Cancer type : Blood

Systemic therapy trial

AMLM22/D1 : The International Acute myeloid leukaemia (AML) Platform Consortium (IAPC) trial is a...

This phase II trial is comparing the safety and effectiveness of a new, experimental treatment and standard of care in patients with acute myeloid leukaemia in complete first remission

Cancer type : Acute Myeloid Leukaemia

Systemic therapy trial

NHL33 : An Australasian Leukaemia & Lymphoma Group (ALLG) Window study of Acalbrutinib plus...

This phase II trial is assessing the safety and effectiveness of using targeted therapy and chemotherapy to treat fit patients with previously untreated mantle cell lymphoma, with or without a stem cell transplant and further maintenance therapy

Cancer type : Mantle Cell Lymphoma

Systemic therapy trial

A Modular Phase I/II, Open-label, Multicentre Study to Assess AZD4573 in Novel...

This phase I/II study is trying to determine the appropriate dosing of a targeted therapy (AZD4573) alone, and then evaluate how effective it is when combined with another targeted therapy (acalabrutinib), in people with advanced blood cancers

Cancer type : Blood

Systemic therapy trial

ASSURE : A Phase 3b, Multicenter, Open-Label, Single-Arm Study of Acalabrutinib (ACP-196) in...

This phase III trial is evaluating the safety and effectiveness of a targeted therapy in patients with chronic lymphocytic leukaemia

Cancer type : Blood

Multiple treatment types

TOP GEAR : A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative...

This phase II/III trial is comparing preoperative chemradiotherapy with preoperative chemotherapy for patients with resectable gastric cancer

Cancer type : Stomach

Systemic therapy trial

BLOCK PCNSL (NHL32) : An ALLG Phase II study of pembrolizumab checkpoint blockade following chemoimmunotherapy...

This phase II study is trying to determine if standard chemotherapy induction therapy followed by immunotherapy (pembrolizumab) will be effective in maintaining life expectancy with minimal side effects for people with primary central nervous system lymphoma

Cancer type : Blood

Systemic therapy trial

A Phase 3, Randomized, Double-blind Study of Neoadjuvant Chemotherapy Plus Nivolumab...

This phase III trial is trying to determine if giving neoadjuvant, then adjuvant immunotherapy will prolong survival in patients with early stage non-small cell lung cancer

Cancer type : Non-Small Cell Lung Cancer

Systemic therapy trial

STOP-GAP : A Randomized Phase III Trial of the Duration of Anti-PD-1 Therapy in Metastatic Melanoma

This phase III trial is comparing the effectiveness of giving immunotherapy (PD-1 inhibitors) intermittently as opposed to continuously, for the treatment of metastatic melanoma

Cancer type : Melanoma (Skin)

Systemic therapy trial

Keynote-B49 : A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of Pembrolizumab Plus...

This phase III trial is trying to understand how safe and effective immunotherapy (pembrolizumab) is when combined with chemotherapy in people with hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer

Cancer type : Breast

Systemic therapy trial

A Phase I Study of Safety, Tolerability, Pharmacokinetic and Pharmacodynamics Property of...

This Early Phase I trial is trying to understand how safe and tolerable a targeted therapy (APG-2575) is in people with cancers of the blood, bone marrow and lymph nodes

Cancer type : Blood

Systemic therapy trial

Treatment of Newly Diagnosed Diffuse Anaplastic Wilms Tumors (DAWT) and Relapsed...

This phase II trial is evaluating how well combinations of chemotherapy (UH-3 and ICE/Cyclo/Tropo) work in treating children, adolescents and young adults with newly diagnosed stage II-IV diffuse anaplastic Wilm's Tumour (DAWT) or relapsed favourable histology Wilm's Tumour (FHWT)

Cancer type : Wilm's tumour

Multiple treatment types

FaR-RMS : An overarching study for children and adults with Frontline and Relapsed RhabdoMyoSarcoma

This study is evaluating the impact of new cancer treatments in both newly diagnosed and relapsed rhabdomyosarcoma patients; it will determine whether changing the duration of maintenance therapy affects outcome; and whether changes to dose, extent and timing of radiotherapy improve outcomes and quality of life for patients

Cancer type : Sarcoma

Systemic therapy trial

TOTAL17 : Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and...

This phase II/III trial is trying to understand how effective using a combination of cancer treatments (including chemotherapy, targeted therapy and immunotherapy) to target specific genes is when treating children with acute lymphoblastic leukaemia (ALL) and acute lymphoblastic lymphoma (LLy)

Cancer type : Blood

Systemic therapy trial

COZMOS : Phase I/Ib Trial of Combined 5'Azacitidine and Carboplatin for Recurrent/Refractory...

This phase I trial is testing a cancer drug that works by switching on genes to stop cancer growth, to see if it is a suitable treatment for children whose brain cancer has not responded to, or has gotten worse on, prior treatment

Cancer type : Brain and Spinal

Systemic therapy trial

FIREFLY-1 : FIREFLY-1: A Phase 2, Open-Label, Multicenter Study to Evaluate the Safety and Efficacy...

This phase II trial is evaluating how safe and effective targeted therapy (DAY101) is in children, adolescents and young adults with recurrent or progressive, low-grade glioma with a known BRAF alteration

Cancer type : Glioma

Systemic therapy trial

AREN1921 : Treatment of Newly Diagnosed Diffuse Anaplastic Wilms Tumors (DAWT) and Relapsed...

This phase II trial is evaluating the effects of different combinations of chemotherapy (UH-3 and ICE/Cyclo/Topo) in people with newly diagnosed stage II-IV diffuse anaplastic Wilm's Tumour (DAWT) or favourable histology Wilm's Tumour (FHWT) that has come back (relapsed)

Cancer type : Wilm's tumour

Systemic therapy trial

Stopping Tyrosine Kinase Inhibitors (TKI) to Assess Treatment-Free Remission (TFR) in...

This phase II trial is evaluating whether stopping targeted therapy (tyrosine kinase inhibitors) affects treatment-free remission in people with chronic phase myeloid leukaemia

Cancer type : Chronic Myelogenous Leukaemia

Systemic therapy trial

AGAVE-201 : AGAVE-201, A Phase 2, Open-label, Randomized, Multicenter Study to Evaluate the Efficacy,...

This phase II trial is trying to understand how safe and effective targeted therapy (axatilimab) is at three different dose levels in people with recurrent or refractory active chronic Graft versus Host disease

Cancer type : Graft versus Host disease

Systemic therapy trial

TRITON3 : A Multicenter, Randomized, Open Label Phase 3 Study of Rucaparib Versus Physician's...

This phase III trial is comparing an oral drug (Rucaparib) with standard treatment in patients who have metastatic castration-resistant prostate cancer

Cancer type : Prostate

Systemic therapy trial

BOND-003 : A Phase 3 Study of CG0070 in Patients With Non-Muscle Invasive Bladder Cancer (NMIBC)...

This phase III trial is evaluating how effective administering immunotherapy (CG0070) through a tube directly into the bladder is to treat non-muscular invasive bladder cancer who have had previous immunotherapy (BCG)

Cancer type : Bladder

Systemic therapy trial

Celestimo : Phase III Randomized, Open-Label, Multicenter Study Evaluating Efficacy and Safety of...

This Phase III trial is comparing the effectiveness of two targeted therapies (mosunetuzumab and rituximab) when they are combined with another cancer drug (lenalidomide) in people with follicular lymphoma who have received previous treatment

Cancer type : Follicular Lymphoma

Systemic therapy trial

GLORIA : The GLORIA Study: A Phase 3, Randomized, Open-Label Study of the Anti-Globo H Vaccine...

This Phase III study is trying to understand the safety and effectiveness of immunotherapy (adagloxad simolenin) on improving outcomes for those with early stage, high risk triple negative breast cancer

Cancer type : Breast

Systemic therapy trial

PREACH-M : Precision Medicine for Chronic Myelomonocytic Leukaemia in Adults: A phase II Trial...

This phase II trial is trying to understand whether treatment responses for people with Chronic Myelomonocytic Leukaemia can be improved by targeting certain gene mutations with certain cancer drugs (such as lenzilumab, azacitidine and sodium ascorbate)

Cancer type : Leukaemia

Systemic therapy trial

HERIZON-GEA-01 : A Randomized, Multicenter, Phase 3 Study of Zanidatamab in Combination With Chemotherapy...

This Phase III trial is seeking to find out if one targeted therapy (zanidatamab), when given with chemotherapy (capecitabine plus oxaliplatin or 5-fluorouracil plus cisplatin) with or without another targeted therapy (tislelizumab), is safe and works better than a different targeted therapy (trastuzumab) plus chemotherapy, in patients with HER2-positive cancers of the stomach or oesophagus

Cancer type : Stomach

Systemic therapy trial

IMbrave050 : A Phase III, Multicenter, Randomized, Open-Label Study of Atezolizumab (Anti-PD-L1...

This phase III trial is trying to understand how safe and effective an adjuvant therapy is compared to active surveillance in patients that have had their hepatocellular (liver) cancer removed or destroyed and who have a high risk of their cancer coming back

Cancer type : Liver

Systemic therapy trial

Interfant 06 : International collaborative treatment protocol for infants under one year with acute...

This trial is studying how well different therapies work in treating infants with newly diagnosed acute leukemia

Cancer type : Acute Lymphoblastic Lymphoma

Systemic therapy trial

LCH-IV : International Collaborative Treatment Protocol for Children and Adolescents With...

This phase II/III trial is looking at different treatment protocols for children and adolescents with Langerhans Cell Histiocytosis

Cancer type : Langerhans Cell Histiocytosis

Radiotherapy trial

SIOPEN LINES : European Low and Intermediate Risk Neuroblastoma Protocol

This Phase III trial is managing the treatment (which may involve chemotherapy, radiotherapy and/or surgery) of people with low and intermediate risk patients with neuroblastoma

Cancer type : Neuroblastoma

Systemic therapy trial

AALL1731 : A Phase 3 Trial Investigating Blinatumomab (NSC# 765986) in Combination With Chemotherapy...

This Phase III trial is evaluating how well targeted therapy (blinatumomab) works in combination with chemotherapy in treating people with newly diagnosed, standard risk B-lymphoblastic leukaemia or B-lymphoblastic lymphoma.

Cancer type : Blood

Systemic therapy trial

AALL1732 : A Phase 3 Randomized Trial of Inotuzumab Ozogamicin (NSC#: 772518) for Newly Diagnosed...

This Phase III trial is assessing whether adding a targeted therapy (inotuzumab ozogamicin) to post-induction chemotherapy for people with high risk B-cell acute lymphoblastic leukaemia improves outcomes

Cancer type : Blood

Systemic therapy trial

A Phase 1 Open-Label, Multicenter Study to Evaluate Biomarkers for ZN-c5 in Subjects With...

This phase I trial is testing a new oral drug in patients with ER+, HER2- breast cancer

Cancer type : Breast

Systemic therapy trial

AMEERA-5 : A Randomized, Multicenter, Double-blind Phase 3 Study of SAR439859 Plus Palbociclib...

This phase III trial is trying to find the best combination of cancer drugs (SAR439859 + palbociclib, compared to letrozole + palbociclib) to improve survival in patients with ER+, HER2- advanced breast cancer who have not received prior treatment for advanced disease

Cancer type : Breast

Systemic therapy trial

MS0055 : Gemcitabine plus cisplatin with or without Bintrafusp Alfa (M7824) in participants with...

This phase II/III trial is evaluating the effectiveness of a novel immunotherapy (Bintafusp Alfa) in combination with the standard of care chemotherapy (Gemcitabine and Cisplatin) to treat patients with locally advanced or metastatic Biliary Tract Cancer

Cancer type : Bile duct

Systemic therapy trial

VALENTINE-PTCL01 : Single-arm, Phase 2 Study of Valemetostat Tosylate Monotherapy in Subjects With...

This Phase II trial is evaluating how safe and effective a new targeted therapy (valemetostat tosylate) is in patients with relapsed or refractory peripheral T-cell lymphoma, including adult T-cell leukaemia/lymphoma patients

Cancer type : Blood

Systemic therapy trial

A Phase 1a/1b Study of PSB202 in Patients With Previously Treated-, Relapsed-, Indolent...

This Phase I study is trying to understand the recommended dose, safety and effective of a new targeted therapy (PSB202) in people with previously treated B-cell cancers

Cancer type : Blood

Systemic therapy trial

A Phase I/II, Open-Label, Multicentre Study to Investigate the Safety, Tolerability,...

This Phase I/II trial is evaluating how safe and tolerable a new oral targeted therapy (AZD4205) is in people with peripheral T-Cell lymphoma

Cancer type : T-Cell Lymphoma

Systemic therapy trial

An Open-Label Study to Assess the Anti-Tumor Activity and Safety of REGN1979, an Anti...

This phase II trial is testing a new targeted therapy in patients with B-cell Non-Hodgkin Lymphoma, whose cancer has got worse or will not respond to other treatments

Cancer type : Blood

Systemic therapy trial

Olema : A Phase 1 Dose Escalation and Dose Expansion Open-label, Multicenter, Study of OP-1250 in...

This Phase I trial is seeking to determine the recommended dose, safety and tolerability of a new hormone therapy (OP-1250) in combination with targeted therapy (palbociclib) in people with advanced or metastatic HR+ and HER2- breast cancer

Cancer type : Breast

Systemic therapy trial

BelaCarD : A phase I/II single arm study on the efficacy of combination Belantamab Mafodotin,...

This phase I/II trial will begin to understand how effective a combination therapy (BelaMafKd) is for the treatment of relapsed or refractory multiple myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

EZH-302 : A Phase 1b/3 Double-blind, Randomized, Active-controlled, 3-stage, Biomarker Adaptive...

This Phase III trial is evaluating how safe and effective a targeted therapy (tazemetostat) is in combination with other cancer drugs (lenalidomide and rituximab) in people with follicular lymphoma who have had at least one prior treatment of chemotherapy, immunotherapy or chemoimmunotherapy

Cancer type : Follicular Lymphoma

Systemic therapy trial

BRUIN-MCL-321 : A Phase 3 Open-Label, Randomized Study of LOXO-305 Versus Investigator Choice of BTK...

This Phase III trial is evaluating the effectiveness of a targeted therapy (LOXO-305) compared to other similar targeted therapies (ibrutinib, acalabrutinib, and zanubrutinib) in people with mantle cell lymphoma

Cancer type : Mantle Cell Lymphoma

Treatment trial

GUIDE : A Randomised Non-comparative Phase II Trial of Biomarker-driven Intermittent Docetaxel...

This Phase II trial is trying to understand how effective chemotherapy (docetaxel) is when delivered intermittently, compared to continuously, in men with metastatic castration-resistant prostate cancer

Cancer type : Prostate

Systemic therapy trial

SAMETA : A Phase III, Open Label, Randomised, 3-Arm, Multi-Centre Study of Savolitinib Plus...

This trial is comparing three different types and combinations of targeted therapy for the treatment of papillary renal cell carcinoma that has spread locally or to distant locations in the body

Cancer type : Urinary System

Systemic therapy trial

INTEGRATE II : A Randomised Phase III Double-Blind Placebo-Controlled Study of Regorafenib in Refractory...

This phase III trial is testing the oral drug, regorafenib, for the treatment of refractory and advanced gastro-oesophageal cancers

Cancer type : Stomach

Systemic therapy trial

M20-732 : A Phase 1b/2, Randomized, Controlled, Open-Label Study Evaluating the Safety and Efficacy...

This Phase II trial is evaluating how safe and effective a targeted therapy (ABBV-927) is when combined with chemotherapy (mFFX) both with or without another targeted therapy (budigalimab), compared to mFFX alone, in adults with untreated metastatic pancreatic cancer

Cancer type : Pancreas

Systemic therapy trial

ADVANTIG-02 : A Phase 3, Randomized, Double-Blind Study of BGB-A1217, an Anti-TIGIT Antibody, in...

This Phase III trial is trying to understand effective different combinations of targeted and immunotherapies (Tislelizumab, Ociperlimab, and Pembrolizumab) are in people with non-small cell lung cancer

Cancer type : Non-Small Cell Lung Cancer

Systemic therapy trial

BGB-301 : A Randomized Phase 3 Study of Tislelizumab in Combination With Sitravatinib in Patients...

This phase III trial will evaluate the combination of two types of targeted therapy to determine if it will be safe and effective to treat people that have been diagnosed with locally advanced or metastatic non-small cell lung cancer that has progressed (got worse) following previous chemotherapy

Cancer type : Lung

Systemic therapy trial

CAPItello-291 : A Phase III Double-blind Randomised Study Assessing the Efficacy and Safety of...

This phase III trial is trying to understand whether it is more or less effective to use hormone therapy alone or in combination with a targeted cancer drug for the treatment of advanced HR+/HER2- breast cancer that has gotten worse or come back on prior treatment

Cancer type : Breast

Systemic therapy trial

FIDES-02 : An Open-label Multi-cohort Phase 1b/2 Study of Derazantinib and Atezolizumab in Patients...

This Phase I/II trial is evaluating the efficacy of targeted therapy (derazantinib) alone, or in combination with immunotherapy (atezolizumab) in people with advanced bladder (urothelial) cancer

Cancer type : Urothelial

Multiple treatment types

PRIMORDIUM : A Randomized, Controlled, Multicenter, Open-label Study to Investigate the Efficacy and...

This phase III trial is evaluating whether radiotherapy and LHRH agonist are a more effective treatment when also combined with apalutamide (hormone therapy) in people with prostate cancer

Cancer type : Prostate

Systemic therapy trial

ARRAY 165-112 : A Multicenter, Open-label Phase 1b Study of the Combination of Binimetinib and...

This Phase I trial is evaluating how safe and effective combining to targeted therapies (binimetinib and encorafenib) is in adolescents with BRAF V600-mutant advanced or metastatic melanoma

Cancer type : Melanoma (Skin)

Surgical trial

A Phase I Study of PTM-101 as Neoadjuvant Therapy for Borderline Resectable or Locally...

This Phase I trial is evaluating the effectiveness of a new cancer treatment (PTM-101) in people with boderline resectable or locally advanced pancreatic cancer

Cancer type : Pancreas

Systemic therapy trial

TALAPRO-3 : TALAPRO-3: A PHASE 3, RANDOMIZED, DOUBLE-BLIND, STUDY OF TALAZOPARIB WITH ENZALUTAMIDE...

This Phase III trial is evaluating how safe and effective a targeted therapy (talzoparib) is in combination with hormone therapy (enzalutamide), compared to a placebo, in people with DDR-deficient metastatic castration-sensitive prostate cancer

Cancer type : Prostate

Systemic therapy trial

A Phase 1b Study of BMS-986158 Monotherapy and in Combination With Either Ruxolitinib or...

This phase I trial aims to understand how safe, well tolerated and effective a new targeted cancer drug (BMS-986158) is in people with DIPSS-intermediate or high risk Myelofibrosis, when given alone or in combination with targeted cancer treatment (Ruxolitinib or Fedratinib)

Cancer type : Blood

Systemic therapy trial

POSNOC : POsitive Sentinel NOde: Adjuvant Therapy Alone Versus Adjuvant Therapy Plus Clearance or...

This trial is comparing the effect of having adjuvant therapy on its own, or in combination with axillary treatment, in women with early stage breast cancer

Cancer type : Breast

Multiple treatment types

CHEST RT : A phase II study of platinum and etoposide chemotherapy, durvalumab with thoracic...

This phase II trial aims to understand how safe and effective it is to use a combination of chemotherapy, immunotherapy and chest radiation therapy to treat extensive stage small cell lung cancer

Cancer type : Lung

Systemic therapy trial

A Phase 2, Randomized, Double-blind Study of Ociperlimab (BGB A1217) and Tislelizumab...

This phase II trial is testing the safety and effectiveness of a new targeted therapy, given in combination with another type of targeted therapy and chemotherapy, for the treatment of people with non-small cell lung cancers that have spread to other parts of the body

Cancer type : Lung

Systemic therapy trial

BCG+MMC : Adding mitomycin C to Bacillus of Calmette-Guerin (BCG) as adjuvant intravesical therapy...

This phase III trial is looking at the effect of adding mitomycin C (a chemotherapy drug) to standard treatment, in patients with invasive bladder cancer

Cancer type : Bladder

Systemic therapy trial

KEYNOTE-866 : A Phase 3, Randomized, Double-blind Study to Evaluate Perioperative Pembrolizumab...

This phase III trial is evaluating the effectiveness of administering a targeted therapy (Pembrolizumab) in combination with chemotherapy drugs (Gemcitabine and Cisplantin) before surgery to treat patients with bladder cancer

Cancer type : Bladder

Systemic therapy trial

Lynk 003 : A Phase 3 Randomized, Open-label Study to Evaluate the Efficacy and Safety of Olaparib...

This phase III trial is trying to evaluate the safety and effectiveness of a targeted cancer drug, given alone and in combination with another targeted cancer drug or chemotherapy, for the treatment of patients with a colorectal cancer that has spread to other parts of the body

Cancer type : Colorectum

Systemic therapy trial

KEYNOTE-756 : A Randomized, Double-Blind, Phase III Study of Pembrolizumab Versus Placebo in...

This phase III trial is evaluating an immunotherapy in combination with pre-treatment (neoadjuvant) chemotherapy and post-treatment (adjuvant) hormone therapy for the treatment of ER+/HER2- breast cancer

Cancer type : Breast

Systemic therapy trial

A Phase 1/1b Dose-Escalation Trial Evaluating CPI-818, an Oral Interleukin-2-Inducible...

This phase I trial is evaluating the safety and dose of a new oral drug (CPI-818) in patients with T-Cell Lymphoma who have got worse or not responded to prior treatment

Cancer type : T-Cell Lymphoma

Systemic therapy trial

RAMPART : An International Investigator-led Phase III Multi Arm Multi Stage Multi-centre Randomised...

This phase III trial is trying to assess whether using a single type of immunotherapy or a combination of two types of immunotherapy will improve survival outcomes for people with renal cell carcinoma that has been surgically removed, when compared to current standard-of-care (active monitoring)

Cancer type : Urinary System

Systemic therapy trial

RePLY : ALLG NHL26 A Phase 2 Study of patients treated for relapsed Follicular Lymphoma: with...

This phase II trial is evaluating the combination of revlimid (chemotherapy) and rituximab maintenance therapy in the treatment of patients with Follicular Lymphoma

Cancer type : Follicular Lymphoma

Treatment trial

A Phase II, Open Label, Randomized, Two-Arm Study to Investigate the Efficacy and Safety...

This Phase II trial is trying to understand how safe and effective an immunotherapy drug (Belantamab mafodotin) is in people with multiple myeloma that Anti-CD38 antibody targeted treatments have been unsuccessful for

Cancer type : Multiple Myeloma

Systemic therapy trial

MAPLE-1 : A Phase Ib /II Open-label, Multi-center Study to Evaluate the Safety, Tolerability and...

This Phase I trial is trying to understand how safe, tolerable and effective different doses of a targeted therapy drug (APG-2575) is alone, or in combination with other treatments such as chemotherapy (including ibrutinib or rituzimab) in people with Waldenström Macroglobulinemia

Cancer type : B-Cell Non Hodgkin Lymphoma

Systemic therapy trial

KOM-PAX1 : A Phase 2, open-label study of orally administered PAX-1 in combination with standard of...

This Phase II trial is trying to understand the effectiveness of an oral drug (PAX-1) in combination with standard of care treatment in people with newly diagnosed or recurrent glioblastoma

Cancer type : Glioblastoma (GBM)

Systemic therapy trial

CheckMate 9N9 : A Study Of Nivolumab In Combination With Trametinib With Or Without Ipilimumab In...

This trial is evaluating the effectiveness of a combination of targeted therapies (Nivolumab and Trametinib), with or without immunotherapy (Ipilimumab) to treat patients with recurrent metastatic colon or rectum cancer

Cancer type : Bowel

Systemic therapy trial

An Open-label, Randomized Phase 3 Study to Evaluate Efficacy and Safety of Pembrolizumab...

This Phase III trial is evaluating how safe and effective combinations of immunotherapy (pembrolizumab) and targeted therapies (lenvatinib, quavonlimab, belzutifan) are in people with advanced clear cell renal cell carcinoma

Cancer type : Renal cell carcinoma

Systemic therapy trial

FRAIL-M : Frailty-stratified, randomised controlled Bayesian adaptive trial of bortezomib versus...

This phase I/II trial is looking at the most appropriate treatment approaches for patients with newly diagnosed multiple myeloma, taking into consideration patient frailty (weakness)

Cancer type : Multiple Myeloma

Systemic therapy trial

Open-label, Randomized Phase II Trial With BNT111 and Cemiplimab in Combination or as...

This Phase II trial is evaluating how safe and effective a targeted therapy (BNT111) is when used by itself or combined with immunotherapy (cemiplimab) in people with anti-PD1-refractory or relapsed melanoma

Cancer type : Melanoma (Skin)

Systemic therapy trial

DREAMM 6 : A Phase I/II, Open-label, Dose Escalation and Expansion Study to Evaluate Safety,...

This phase II trial is measuring the safety and recommended dose of an immunotherapy drug (GSK2857916) in combination with another cancer drug (Bortezomib or Lenalidomide) and a steroid for the treatment of multiple myeloma that has got worse or is not responsive to other treatments

Cancer type : Multiple Myeloma

Systemic therapy trial

An Open-Label, Multicenter, Phase I Trial Evaluating The Safety And Pharmacokinetics Of...

This phase I trial is trying to understand how a new intravenous drug works, and if it is safe and tolerable to use, in the treatment of patients with multiple myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

An Open-Label, Multicenter, Phase I Trial Evaluating the Safety and Pharmacokinetics of...

This phase I trial is evaluating an intravenous drug (BFCR4350A) in patients with multiple myeloma, who have progressed or not responded to prior treatment

Cancer type : Multiple Myeloma

Systemic therapy trial

NKARTA : A Phase 1 Study of NKX101, an Activating Chimeric Receptor Natural Killer Cell Therapy,...

This Phase I trial is evaluating how safe and tolerable an experimental targeted therapy (NKX101) is in people with acute myeloid leukaemia or myelodysplastic syndromes

Cancer type : Blood

Systemic therapy trial

COSTAR Lung : A Randomized, Open Label Phase 2/3 Study Comparing Cobolimab + Dostarlimab + Docetaxel To...

This Phase II study is trying to understand the effectiveness of a targeted therapy drug (cobolimab) in combination with another type of targeted therapy (dostarlimab) and chemotherapy (docetaxel) in people with advanced non-small cell lung cancer

Cancer type : Lung

Systemic therapy trial

SOLSTICE : An Open-label, Randomised, Phase III Study comparing TrifLuridine/Tipiracil (S95005) in...

This phase III trial is comparing the effectiveness of two different combinations of chemotherapy and targeted therapy drugs (Trifluridine/tipiracil hydrochloride and Bevacizumab versus Capecitabine and Bevacizumab) for treating patients with metastatic colorectal cancer, who are not candidates for intensive therapy.

Cancer type : Bowel

Systemic therapy trial

LEAP-006 : A Phase 3 Randomized, Placebo-controlled Study to Evaluate the Safety and Efficacy of...

This Phase III trial is trying to understand how safe and effective a combination of chemotherapy (pemetrexed and platinum chemotherapy) and immunotherapy (pembrolizumab) is with and without a targeted cancer drug (lenvatinib) is in people with metastatic nonsquamous non-small cell lung cancer

Cancer type : Non-Small Cell Lung Cancer

Systemic therapy trial

A Multicenter, Randomized, Double-Blind Phase 3 Study of HBI-8000 Combined With Nivolumab...

This Phase III trial is trying to understand how effective a new anti-cancer drug (HBI-8000) is in combination with immunotherapy (Nivolumab) in people with advanced melanoma

Cancer type : Melanoma (Skin)

Radiotherapy trial

PIONEER : A Pilot Study of Prone Position Neoadjuvant Breast Radiotherapy to Reduce Skin Toxicity

This trial is trying to determine the best way of delivering radiation therapy to the breast tissue of people diagnosed with invasive, Grade 1, 2 or 3 breast cancer, before surgery

Cancer type : Breast

Systemic therapy trial

INTEGRATEIIb : A Randomised Phase III Open Label Study of Regorafenib + Nivolumab vs Standard...

This Phase III trial is trying to determine if a combined treatment of targeted and immunotherapy drugs (regorafenib and nivolumab) is more effective than the current standard chemotherapy treatments in people with advanced gastro-oesophageal cancer

Cancer type : Stomach

Systemic therapy trial

A Pivotal Phase 1/2, Single-Arm, Open-label Study to Evaluate the Safety and Efficacy of...

This trial is testing how safe and effective a new oral targeted therapy (Ponatinib) is when combined with chemotherapy in the treatment of children, adolescents and young adults diagnosed with Acute Lymphoblastic Leukemia

Cancer type : Blood

Radiotherapy trial

ReRAD : ReRAD: A Phase II Canadian Pediatric Brain Tumour Consortium Study of Re-Irradiation as...

This phase II trial is evaluating the repeat administration of radiotherapy to a previously exposed region of the body, with the aim of treating people with Diffuse Intrinsic Pontine Glioma that is getting worse or has recently come back

Cancer type : Brain and Spinal

Systemic therapy trial

A Phase 2, Open-label, Multicenter Study of TL-895 in Subjects With Relapsed/Refractory...

This phase II trial is trying to determine the effectiveness and dosing level of a targeted therapy drug (TL-895) in people with Myelofibrosis

Cancer type : Myelofibrosis

Systemic therapy trial

LEEP : A Randomised controlled Phase II trial of the pharmacodynamic effects of CDK4/6 inhibitor...

This phase II trial is trying to determine the effectiveness of a targeted cancer drug (ribociclib) at slowing down the growth of prostate cancer cells

Cancer type : Prostate

Systemic therapy trial

Xenera-1 : A Multi-centre, Double-blind, Placebo-controlled, Randomised Phase II Trial to Compare...

This phase II trial is evaluating a new form of immunotherapy (xentuzumab) to see whether it enhances combination treatment with a chemotherapy drug (Everolimus) and hormone therapy drug (Exemestane) in patients with hormone receptor positive (HR+), HER2- breast cancer that has spread to other parts of the body

Cancer type : Breast

Systemic therapy trial

MODULATE : Modulation Of The Tumour Microenvironment Using Either Vascular Disrupting Agents or...

This phase II trial is evaluating the combination of nivolumab (an immunotherapy drug) and two other drugs (BNC105 or BBI608) in patients with colorectal cancers that have spread to other parts of the body and have failed prior therapies

Cancer type : Bowel

Systemic therapy trial

COSMIC-313 : A Randomized, Double-Blind, Controlled Phase 3 Study of Cabozantinib in Combination With...

This phase III trial is combining a targeted cancer treatment and immunotherapy treatment to see how this combination impacts survival outcomes for people whose renal cell carcinoma (a type of cancer) has spread to other parts of the body

Cancer type : Urinary System

Systemic therapy trial

Destiny-Breast 02 : A Phase 3, Multicenter, Randomized, Open-label, Active-controlled Study of DS-8201a, an...

This Phase III trial is comparing an anti-HER2-antibody drug with standard of care therapy in patients with pre-treated, HER2-positive breast cancer that has spread to other parts of the body

Cancer type : Breast

Systemic therapy trial

A Phase 1b/2 Study of Immune and Targeted Combination Therapies in Participants With RCC...

This trial will evaluate different combinations of targeted cancer treatment in patients with clear cell renal cell carcinoma (ccRCC)

Cancer type : Urinary System

Multiple treatment types

NUTMEG : A Randomised Phase II Study of NivolUmab and TeMozolomide vs Temozolomide alone in newly...

This phase II trial is comparing the effect of a chemotherapy drug (Temozolomide) alone and in combination with an immunotherapy drug (Nivolumab) for the treatment of elderly patients with a newly diagnosed glioblastoma

Cancer type : Brain and Spinal

Systemic therapy trial

KEYNOTE-U03 : A Phase 1b/2 Study of Immune and Targeted Combination Therapies in Participants With RCC...

This trial will evaluate the safety and effectiveness of different treatment combinations in patients with newly diagnosed, advanced clear cell renal cell carcinoma

Cancer type : Urinary System

Systemic therapy trial

Resilient : A Randomized, Open Label Phase 3 Study of Irinotecan Liposome Injection (ONIVYDE®) Versus...

This phase II/III trial is comparing two intravenous drugs (Irinotecan liposome injection and Topotecan injection) in patients with small cell lung cancer who have gotten worse after first line therapy

Cancer type : Lung

Surgical trial

MelMarT Trial : A Phase III, multi-centre, multi-national randomised control trial investigating 1cm v...

This phase III trial is trying to determine whether a smaller surgical margin will be effective in the removal of primary cutaneous melanoma and improve patient quality of life

Cancer type : Melanoma (Skin)

Treatment trial

FeRIC (Fe dEficiency in ColoRectal Cancer) : An iron infusion with Ferric Carboxymaltose as a technique of improving physiological...

This phase IV trial is trying to determine if giving an iron infusion to iron-deficient colorectal cancer patients who are anaemic versus not anaemic will improve their physical fitness for planned surgery

Cancer type : Colorectum

Radiotherapy trial

LuTectomy : Study of the Dosimetry, Safety and Potential Benefit of 177Lu-PSMA-617 Radionuclide...

This trial aims to evaluate a radiation-based treatment in men with prostate cancer who are undergoing surgery for their cancer

Cancer type : Prostate

Systemic therapy trial

MATCH : Tabelecleucel for Allogeneic Hematopoietic Cell Transplant Subjects With EBV+ PTLD After...

This phase III trial is evaluating an immunotherapy (tabelecleucel) for the treatment of Epstein-Barr Virus-associated post-transplant lymphoproliferative disease in the setting of solid organ transplant after failure of rituximab or rituximab plus chemotherapy

Cancer type : Lymphoma

Systemic therapy trial

AAML1531 : Risk-Stratified Therapy for Acute Myeloid Leukemia in Down Syndrome

This phase III trial is evaluating different types of response-based chemotherapy in treating newly diagnosed Acute Myeloid Leukemia (AML) or Myelodysplastic syndrome in younger patients with Down syndrome

Cancer type : Blood

Systemic therapy trial

A Phase 1, First-in-Human, Dose Escalation Study of the JNJ-75348780 Bispecific Antibody...

This phase I trial is trying to find a safe and effective dose of a new targeted cancer drug, to treat patients with B-cell Non-Hodgkin Lymphoma or Chronic Lymphocytic Leukaemia who have got worse, not responded or are unable to receive other treatment

Cancer type : Blood

Systemic therapy trial

POD1UM-303 / InterAACT 2 : A Phase 3 Global, Multicenter, Double-Blind Randomized Study of Carboplatin-Paclitaxel...

This phase III trial will add a type of immunotherapy to chemotherapy treatment in patients with recurrent or metastatic squamous cell carcinoma of the anal canal, to see if it is more or less effective than using chemotherapy on its' own

Cancer type : Anus

Systemic therapy trial

A Multi-center, Open-label, Phase 1b Study to Assess the Pharmacokinetics, Safety, and...

This phase I trial is testing two different ways to give an immunotherapy drug (isatuximab) to patients with Multiple Myeloma, who have got worse or not responded to prior treatment

Cancer type : Multiple Myeloma

Systemic therapy trial

M19-025 : A First In Human Study of the MCL-1 Inhibitor, ABBV-467

This phase I trial will begin to understand how safe and tolerable an intravenous cancer drug (ABBV-467) is for the treatment of multiple myeloma in patients who have not responded or got worse on previous treatment

Cancer type : Multiple Myeloma

Treatment trial

DREAMM 9 : A Phase 1, Randomized, Dose and Schedule Evaluation Study to Investigate the Safety,...

This phase I trial is trying to determine the safety and recommended dose of an immunotherapy, combined with standard of care treatment, in patients with newly diagnosed multiple myeloma

Cancer type : Multiple Myeloma

Systemic therapy trial

A Phase 1 Pharmacokinetic and Pharmacodynamic Study of TG-1701, an Irreversible Bruton's...

This phase I trial is evaluating the safety and effectiveness of a new oral drug (TG-1701) for patients with B-cell malignancies that have not responded or gotten worse with prior treatments

Cancer type : Blood

Systemic therapy trial

An Open-Label, Phase 2a/2b Study of KRT-232 in Subjects With Primary Myelofibrosis (PMF),...

This phase II trial is evaluating an oral drug (KRT-232) for the treatment of patients with myelofibrosis who are no longer benefiting their current treatment with a JAK inhibitor

Cancer type : Blood

Radiotherapy trial

LASER : Treatment of Locally Advanced non-small cell lung carcinoma with Stereotactic ablativE...

This phase I trial will evaluate whether stereotactic ablative radiotherapy (SABR) is a safe and effective treatment option for patients with non-small cell lung cancer (NSCLC) whose cancer is large and/or has spread to the nearby lymph nodes

Cancer type : Lung

Systemic therapy trial

A Phase Ib, Multi-arm, Open-label, Study of HDM201 in Combination With MBG453 or...

This phase I trial is studying a new oral cancer drug in combination with immunotherapy or chemotherapy for the treatment of acute myeloid leukaemia or high-risk myelodysplastic syndrome

Cancer type : Blood

Systemic therapy trial

ADORE : A Randomized, Open-label, Phase I/II Open Platform Study Evaluating Safety and Efficacy...

This phase I/II trial is evaluating the safety and effectiveness of 5 new drugs in combination treatment for people with myelofibrosis

Cancer type : Blood

Multiple treatment types

KEYNOTE-992 : A Phase 3, Randomized, Double-blind, Placebo-controlled Clinical Trial to Study the...

This phase III trial is evaluating the safety and effectiveness of using chemo-radiotherapy with and without immunotherapy for the treatment of patients with muscle-invasive bladder cancer

Cancer type : Bladder

Systemic therapy trial

KEYNOTEB10 : A Phase 4, Single-arm, Open-label Clinical Study of Pembrolizumab (MK-3475) to Evaluate...

This phase IV trial will evaluate the safety and effectiveness of an immunotherapy, combined with chemotherapy, as first line treatment for patients with recurrent or metastatic head and neck squamous cell carcinoma

Cancer type : Head and neck

Systemic therapy trial

A Randomized, Open-Label Phase 1/2 Study Evaluating Ramucirumab in Pediatric Patients and...

This phase I/II trial is testing the safety and effectiveness of a targeted therapy in combination with chemotherapy in the treatment of relapsed, recurrent, or refractory synovial sarcoma (SS) in children and young adults

Cancer type : Sarcoma

Systemic therapy trial

DUO-O : A Phase III Randomised, Double-Blind, Placebo-Controlled, Multicentre Study of Durvalumab...

This phase III trial is evaluating the safety and effectiveness of various targeted therapy and chemotherapy combinations for the treatment of newly diagnosed, advanced ovarian cancer

Cancer type : Female Reproductive System

Systemic therapy trial

SKYSCRAPER-07 : A Phase III, Randomized, Double-Blind, Placebo-Controlled Study of Atezolizumab With or...

This phase III trial will evaluate how safe and effective two types of immunotherapy are, compared to a placebo, for the treatment of locally advanced oesophageal squamous cell cancer

Cancer type : Oesophagus

Systemic therapy trial

TRITON2 : A Multicenter, Open-label Phase 2 Study of Rucaparib in Patients With Metastatic...

This phase II trial is evaluating the effect of the anti-cancer drug Rucaparib in patients with metastatic castration-resistant prostate cancer

Cancer type : Prostate

Systemic therapy trial

Intrigue : A Phase 3, Interventional, Randomized, Multicenter, Open-Label Study of DCC-2618 vs...

This phase III trial is evaluating two oral therapies (DCC-2618 and sunitinib) in patients with advanced gastrointestinal stromal tumours following prior treatment

Cancer type : Stomach

Systemic therapy trial

ANBL1821 : A Phase 2 Randomized Study of Irinotecan/Temozolomide/Dinutuximab With or Without...

This phase II trial is evaluating a combination of chemotherapy and immunotherapy treatments in patients with neuroblastoma that has come back or not responded to prior treatment

Cancer type : Neuroblastoma

Systemic therapy trial

MyeChild : International Randomised Phase III Clinical Trial in Children With Acute Myeloid...

This phase III trial is comparing two induction chemotherapy treatments in children with Acute Myeloid Leukaemia (AML)

Cancer type : Blood

Systemic therapy trial

FORUM : Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute...

This phase II/III trial is evaluating allogenic stem cell transplatation as an optimal therapy for children and adolescents diagnosed with Acute Lymphoblastic Leukaemia (ALL)

Cancer type : Acute Lymphoblastic Leukaemia

Systemic therapy trial

WinPro : An open-label, randomized, window of opportunity study between diagnosis and definite...

This phase II trial is evaluating a combination of hormone treatments that may be useful for pre-surgery breast cancer treatment

Cancer type : Breast

Systemic therapy trial

SKYSCRAPER-03 : A Phase III, Open-Label, Randomized Study of Atezolizumab and Tiragolumab Compared With...

This phase III trial is comparing the safety and effectiveness of different targeted therapies for the treatment of locally advanced non-small cell lung cancer

Cancer type : Lung

Systemic therapy trial

LEAP-009 : A Phase 2, Randomized, Open-label Three-arm Clinical Study to Evaluate the Safety and...

This phase II trial will test the safety and effectiveness of a targeted cancer drug, alone and in combination with immunotherapy, to see if it is better than standard of care chemotherapy in patients with head and neck cancers that have spread, come back and/or gotten worse after treatment

Cancer type : Head and Neck

Systemic therapy trial

A Phase 1, First-in-Human, Open-Label, Dose Escalation Study of JNJ-61186372, a Human...

This phase I trial is evaluating the safety and recommended dose level of a new drug (intravenous JNJ-61186372) in patients with advanced non-small cell lung cancer (NSCLC)

Cancer type : Non-Small Cell Lung Cancer

Systemic therapy trial

CheckMate 649 : A Randomized, Multicenter, Open-Label, Phase 3 Study of Nivolumab Plus Ipilimumab or...

This phase III trial trying to compare the relative survival of patients who receive either (i) nivolumab and ipilimumab (ii) nivolumab and chemotherapy or (iii) chemotherapy alone for the treatment of oesophageal and gastro-oesophageal junction cancers

Cancer type : Stomach

Systemic therapy trial

LEAP-012 : A Phase 3 Multicenter, Randomized, Double-blinded, Active-controlled, Clinical Study to...

This phase III trial is trying to understand how safe and effective it is to use targeted therapy, immunotherapy and chemotherapy (given directly into the blood vessel) for the treatment of hepatocellular (liver) cancer that has not spread to other parts of the body

Cancer type : Liver

Systemic therapy trial

AMG 509 : A Phase 1 Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of...

This phase I trial is trying to understand how much immunotherapy is safe and effective for the treatment of castration-resistant prostate cancer that has spread to other parts of the body

Cancer type : Prostate

Systemic therapy trial

PISCES : A Multicenter Phase 2, Open-Label Trial of Intratumoral pIL-12 Plus Electroporation in...

This Phase II trial is evaluating an intratumoral therapy (within a tumor) and electroporation (a microbiology technique that applies an electric field to cells in the body) in combination with an immunotherapy agent (Pembrolizumab) in patients with advanced stage II/IV melanoma

Cancer type : Melanoma (Skin)

Systemic therapy trial

NuTide:121 : A Phase III Open-Label, Multi-Centre, Randomized Study Comparing NUC-1031 Plus Cisplatin...

This phase III trial is comparing two chemotherapy combinations for the treatment of advanced biliary tract cancer

Cancer type : Stomach

Systemic therapy trial

Dublin 3 : Randomized Blinded Phase III Assessment of Second or Third-Line Chemotherapy With...

This phase III trial is comparing outcomes for patients with Non-Small Cell (NSC) Lung Cancer, who are receiving second- or third- line chemotherapy with docetaxel alone and in combination with plinabulin, for advanced stage or metastatic disease

Cancer type : Lung

Systemic therapy trial

Impassion 030 : A Phase III, Multicenter, Randomized, Open-Label Study Comparing Atezolizumab (Anti PD-L1...

This phase III trial is comparing the safety and effectiveness of an immunotherapy drug (Atezolizumab) and a chemotherapy drug (Paclitaxel), given in combination with the investigator's choice of standard chemotherapy, for the treatment of stage II or stage III triple negative breast cancer (TNBC)

Cancer type : Breast

Systemic therapy trial

Proteus : A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of Apalutamide in Subjects...

This phase III trial is evaluating an oral prostate cancer treatment (Apalutamide) in patients with high risk, localised or locally advanced prostate cancer who are eligible for surgery

Cancer type : Prostate

Systemic therapy trial

ALTA-2 : Brigatinib in Patients With Anaplastic Lymphoma Kinase-Positive (ALK+), Advanced...

This phase II trial is testing an oral anti-cancer therapy (Brigatinib) in patients who have ALK+ non-small cell lung cancer

Cancer type : Lung

Systemic therapy trial

SPAR : A randomized, placebo-controlled phase II trial of Simvastatin in addition to standard...

This phase 2 trial is assessing the clinical benefit of adding a statin (Simvastatin) to standard chemotherapy and radiotherapy to treat patients with rectal cancer before surgery

Cancer type : Rectum

Systemic therapy trial

ZAP : A Phase 2, Open-Label, Randomized Study to Assess the Antitumor Activity and Safety of...

This phase II trial is evaluating an immunotherapy (zolbetuximab) in combination with chemotherapy (gemcitabine and nab-paclitaxel) in patients who have pancreatic cancer that has spread to other parts of the body

Cancer type : Pancreas

Systemic therapy trial

Checkmate 8HW : A Phase 3b Randomized Clinical Trial of Nivolumab Alone, Nivolumab in Combination With...

This phase 3 trial is comparing the benefit of using targeted therapies, either in combination (Nivolumab plus Ipilimumab) or alone (nivolumab) to treat patients with metastatic colorectal cancer.

Cancer type : Colorectum

Systemic therapy trial

PROOF : A Phase 3 Multicenter, Open-Label, Randomized, Controlled Study of Oral Infigratinib...

This phase 3 study is evaluating the effectiveness and safety of a targeted therapy (Infigratinib) in comparison with the standard of care chemotherapy (Gemcitabine plus Cisplatin) for treatment of patients with inoperable or metastatic cholangiocarcinoma

Cancer type : Bile duct

Multiple treatment types

OUTRUN : A Randomised Phase II Trial of Osimertinib With or Without Stereotactic Radiosurgery for...

This Phase III trial is comparing the effects of giving an oral drug (Osimertinib) alone and in combination with stereotactic radiosurgery (SRS) in patients with non-small cell lung cancer (NSCLC) that has spread to the brain

Cancer type : Lung

Systemic therapy trial

KEYNOTE-630 : A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate Pembrolizumab...

This phase III trial is trying to determine whether an immunotherapy drug (Pembrolizumab) is an effective therapy to give after surgery and radiation in patients with locally advanced cutaneous squamous cell carcinoma

Cancer type : Cutaneous Squamous Cell Carcinoma (CSCC)

Systemic therapy trial

KEYNOTE-564 : A Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Pembrolizumab...

This Phase III trial is evaluating an immunotherapy agent (Pembrolizumab) as a monotherapy for patients who have Renal Cell Carcinoma and have undergone a nephrectomy surgical procedure

Cancer type : Urinary System

Systemic therapy trial

Keynote 057 : A Phase II Clinical Trial to Study the Efficacy and Safety of Pembrolizumab (MK-3475) in...

This phase II trial is evaluating the safety and effectiveness of an immunotherapy (Pembrolizumab) in patients with high risk, non-muscle invasive bladder cancer, who have not responded to prior therapy

Cancer type : Bladder

Systemic therapy trial

PDR001-X2105 : Phase 1b, Multi-arm, Open-label Study of PDR001 and/or MBG453 in Combination With...

This is a phase I trial assessing the safety and tolerability of using immunotherapy drugs (PDR001 and /or MBG453) in combination with chemotherapy (Decitabine) to treat patients with Acute Myleoid Leukaemia or High Risk Myelodysplastic Syndrome

Cancer type : Blood

Systemic therapy trial

CanStem303C : A Phase III Study of BBI-608 in Combination With 5-Fluorouracil, Leucovorin, Irinotecan...

This phase III trial is testing a drug called BBI-608 in combination with other drugs, for patients with previously treated metastatic colorectal cancer (CRC)

Cancer type : Bowel

Systemic therapy trial

A Phase 2, Open-Label Study of Intratumoral Tavokinogene Telseplasmid Plus...

This phase II trial is evaluating a biological therapy (Tavokinogene Telseplasmid - delivered by electroporation), in combination with an immunotherapy drug (Pembrolizumab), in patients with advanced triple negative breast cancer

Cancer type : Breast

Systemic therapy trial

ATOSSA : An open label, pilot and expansion pharmacodynamic Study of (Z)-endoxifen in Patients...

This trial is testing hormone therapy, using oral (Z)-Endoxifen, as a treatment for patients with invasive breast cancer

Cancer type : Breast

Systemic therapy trial

BlinFant : A pilot study to test the feasibility, safety and efficacy of the addition of the BiTE...

This phase II trial is testing the safety of an immunotherapy treatment in infants with newly diagnosed Acute Lymphoblastic Leukaemia (ALL)

Cancer type : Blood

Systemic therapy trial

OZM-063 : A Phase II, Open-Labeled, Multi-Center, Randomized Controlled Trial of Vinblastine +/-...

This phase II trial is trying to determine the benefit of adding Bevacizumab (an intravenous drug) to chemotherapy treatment with Vinblastine, in children and adolescents with low grade gliomas

Cancer type : Glioma

Systemic therapy trial

SCOUT : A Phase 1/2 Study of the Oral TRK Inhibitor LOXO-101 (Larotrectinib) in Pediatric...

This phase I/II trial is using an oral drug (LOXO-101) as a treatment in children and adolescents with central nervous system tumours

Cancer type : Central Nervous System

Multiple treatment types

STABLE-MATES : A Randomised Phase III study of sub-lobar resection (SR) versus Stereotactic Ablative...

This phase III trial is comparing surgery and radiation therapy in the treatment of stage I Non-Small Cell (NSC) Lung Cancer

Cancer type : Lung

Systemic therapy trial

TAHOE : A Randomized, Open-label, Multicenter, Phase 3 Study of Rovalpituzumab Tesirine Compared...

This phase III trial is comparing two drugs (Rovalpituzumab Tesirine and Topotecan) in patients with advanced or metastatic Small Cell Lung Cancer (SCLC) that has gotten worse following front-line chemotherapy

Cancer type : Small Cell Lung Cancer

Systemic therapy trial

KEYNOTE-555 : Relative Bioavailability Study of Subcutaneous Injection Versus Intravenous Infusion of...

This phase I trial is assessing the safety of administering a drug (pembrolizumab) by injection beneath the skin for the treatment of advanced melanoma

Cancer type : Melanoma (Skin)

Multiple treatment types

KEYNOTE-799 : A Trial of Pembrolizumab in Combination With Chemotherapy and Radiotherapy in Stage III...

This phase II trial is testing a drug (pembrolizumab) in combination with chemotherapy and radiotherapy for the treatment of locally advanced Stage III non-small cell lung cancer that cannot be removed by surgery

Cancer type : Lung

Systemic therapy trial

JAVELIN Lung 100 : A Phase III, Open-label, Multicenter Trial of Avelumab (MSB0010718C) Versus...

This phase III trial is comparing the drug, avelumab, with platinum-based doublet chemotherapy in Non-Small Cell (NSC) Lung Cancer patients with PD-L1+ tumours

Cancer type : Lung

Surgical trial

Irreversible Electroporation : The safety and efficacy of Irreversible Electroporation for the ablation of prostate...

This trial is assessing the safety and efficacy of Irreversible Electroporation for the removal of prostate cancer

Cancer type : Prostate

Systemic therapy trial

TACTI-mel : A Multicentre, Open Label, Dose Escalation, Phase 1 Study in Patients With Unresectable...

This phase I trial is trying to determine the recommended dose of a new drug (IMP321) when given in combination with an immunotherapy agent (pembrolizumab) for people with metastatic melanoma

Cancer type : Melanoma (Skin)

Multiple treatment types

SJMB12 : A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma (Other...

This phase II trial will assess the effectiveness of different Medullablastoma treatments in patients, according to their clinical risk and molecular subtype

Cancer type : Medullablastoma

Multiple treatment types

ACNS0831 : Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients With Newly...

This phase III trial is comparing post-radiation chemotherapy and observation for the treatment of young people with newly diagnosed ependymomas

Cancer type : Ependymomas

Systemic therapy trial

feMMe : A Phase II Randomised Clinical Trial of Mirena ± Metformin ± Weight Loss Intervention in...

This phase II trial is trying to determine whether the use of mirena, metformin or a weight loss intervention is effective in the treatment of early-stage endometrial cancer

Cancer type : Endometrium

Systemic therapy trial

AAML1331 : A Phase III Study for Patients With Newly Diagnosed Acute Promyelocytic Leukemia (APL)...

This phase III trial is evaluating tretinoin and arsenic trioxide for the treatment of patients with newly diagnosed Acute Promyelocytic Leukemia

Cancer type : Acute Promyelocytic Leukaemia

Systemic therapy trial

CFZ008 : Phase 1b/2 Study of Carfilzomib in Combination With Dexamethasone, Mitoxantrone,...

This phase I/II trial is trying to determine how much carfilzomib (an anti-cancer drug) should be used, alone and in combination with induction chemotherapy, to treat children with Acute Lymphoblastic Leukaemia (ALL)

Cancer type : Acute Lymphoblastic Leukaemia

Systemic therapy trial

NCT02393859 : Phase 3 Trial to Investigate the Efficacy, Safety, and Tolerability of Blinatumomab as...

This phase III trial is trying to determine whether blinatumomab (a drug) is better as a consolidation therapy than standard chemotherapy for patients with Acute Lymphoblastic Leukaemia (ALL)

Cancer type : Acute Lymphoblastic Leukaemia

Systemic therapy trial

A Phase Ib, Open-Label Study Evaluating the Safety, Pharmacokinetics, and Activity of...

This phase I study is evaluating how safe and effective a new oral drug (GDC-1971) is when given in combination with immunotherapy (atezolizumab) in people with locally advanced or metastatic solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

TRIDENT-1 : A Phase 1/2, Open-Label, Multi-Center, First-in-Human Study of the Safety, Tolerability,...

This phase I/II trial is trying to determine the safety and tolerability of an oral drug, repotrectinib

Cancer type : Multi-Cancer

Treatment trial

An Open-label, Multi-center, Phase I Study of Oral IAG933 in Adult Patients With Advanced...

This phase I study is aiming to determine the best dose level and safety of a new cancer drug (IAG933) in people with advanced mesothelioma and other solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

FLAGSHP-1 : An Open-Label, Multi-Center Phase 1/1b Dose Escalation and Expansion Study of ERAS-601...

This phase I trial is evaluating how safe and effective a targeted cancer drug (ERAS-601) is alone, or when combined with another targeted therapy (Cetuximab) in people with advanced or metastatic solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

A PHASE 1 DOSE ESCALATION AND EXPANSION STUDY EVALUATING THE SAFETY, TOLERABILITY,...

This phase I trial is trying to understand how safe and tolerable a new targeted therapy drug (PF-07062119) is in people with selected advanced or metastatic gastrointestinal cancers

Cancer type : Multi-Cancer

Systemic therapy trial

AROS-1 : A Phase 1/2 Study of the Highly Selective ROS1 Inhibitor NVL-520 in Patients With...

This phase I/II study is seeking to determine the best dose level, safety and effectiveness of a new cancer drug (NVL-250) in people with locally advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

PARAGON II : The activity and tolerability of Aromatase inhibitor plus PI3KCA inhibitor or CDK4/6...

This phase II study is evaluating the effectiveness of hormone therapy (letrozole) when combined with targeted therapy (alpelisib or ribociclib) in post-menopausal women with advanced gynaecological cancers that are hormone-receptor positive

Cancer type : Multi-Cancer

Systemic therapy trial

Investigating the safety and tolerability of PMR-116 in Patients with Advanced...

This phase I trial is trying to understand the safety of a new targeted therapy (PMR-116) in people with advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

CERTIS1 : A Modular Phase I/IIa, Open-label, Multi-centre Study to Assess the Safety, Tolerability,...

This phase I/II study is evaluating how safe, tolerable and effective a new targeted therapy (AZD9574) is alone, or in combination with chemotherapy (temozolomide) in people with advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

HLX20 : A Phase 1 Study of HLX20, a Human Monoclonal Antibody Targeting Programmed Death Ligand 1...

This phase I trial is testing a new drug (HLX20) for people whose cancer has spread or come back following prior therapy

Cancer type : Multi-Cancer

Systemic therapy trial

An Open-Label, Multi-center, Dose-Escalation Phase I Study to Evaluate Safety,...

This phase I trial is testing a new drug (KN046) in patients with advanced cancers who are not able to have any other standard therapies

Cancer type : Multi-Cancer

Systemic therapy trial

A phrase I, open-label, multi-center, non-randomized, dose escalation study to evaluate...

This phase I trial is evaluating the effectiveness, safety and tolerance for a targeted therapy (XNW7201) to treat patients with locally advanced or metastatic solid tumours.

Cancer type : Multi-Cancer

Systemic therapy trial

Safety, Tolerability, Pharmacokinetics, Biological, and Clinical Activity of AGEN2034 in...

This phase I/II trial evaluates the effectiveness, safety and tolerability of an immunotherapy (AGEN2034) for treatment of patients with metastatic or locally advanced solid tumours, and recurrent or metastatic cervical cancer that has progressed after chemotherapy

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase I, Open Label, Multi-Center, Dose Escalation Clinical Study to Evaluate the...

This phase I trial is testing a new intravenous treatment for people with advanced solid cancers or B-cell lymphoma

Cancer type : Multi-Cancer

Systemic therapy trial

ARCUS Breast/Gyne : A Phase 1/1b Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations...

This phase I trial is testing different chemotherapy and immunotherapy combinations in patients with advanced triple-negative breast cancer or ovarian cancer

Cancer type : Multi-Cancer

Systemic therapy trial

ARCUS GI : A Phase 1/1b Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations...

This phase I trial is evaluating an immunotherapy and chemotherapy combination in patients with advanced gastroesophageal cancer or colorectal cancer

Cancer type : Multi-Cancer

Systemic therapy trial

First-in-human (FIH), Open-Label, Phase I (Dose Escalation) Study of ADG116 in Patients...

This phase I trial is evaluating a new targeted therapy in patients with advanced cancers and cancers that have spread to other parts of the body

Cancer type : Multi-Cancer

Systemic therapy trial

Open-Label Phase 2 Study of Ladiratuzumab Vedotin (LV) for Unresectable Locally Advanced...

This phase II trial is trying to determine how safe and tolerable a targeted therapy is for the treatment of several different cancer types

Cancer type : Multi-Cancer

Systemic therapy trial

Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Anti-tumor Activity...

This phase I trial is evaluating the safety of a drug (FN-1501) in patients with advanced solid tumours

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1 Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in...

This phase I trial is evaluating the combination of two immunotherapy drugs (AB928 and AB122) in patients with certain types of advanced cancer

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1b/2 Study of BMS-813160 in Combination With Chemotherapy or Nivolumab in...

This phase I/II trial is evaluating the safety and effectiveness of an oral drug (BMS-813160) alone or in combination with immunotherapy (Nivolumab) and/or chemotherapy in patients with advanced solid cancers, particularly colorectal cancer or pancreatic cancer

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase I, Multi-center, Open-label, Dose Escalation Study of CS3005 in Subjects With...

This phase I trial is trying to find the best dose of a chemotherapy in patients with advanced solid cancers (excluding some types of blood cancer)

Cancer type : Multi-Cancer

Treatment trial

A Phase 1, First-In-Human, Multicenter, Open-Label, Study of GQ1001, a HER2 Targeted...

This phase I trial is testing different doses (amounts) of a new targeted therapy in adults with HER2-positive cancer

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase I, Multi-Center, Open-Label Study to Evaluate the Safety and Tolerability,...

This phase I trial will evaluate how safe and tolerable a new oral cancer drug is for the treatment of advanced solid cancers, when given alone or in combination with a type of immunotherapy

Cancer type : Multi-Cancer

Systemic therapy trial

First-in-human (FIH), Open-Label, Phase I Dose Escalation Study of ADG126 in Patients...

This phase I study seeks to understand the safety of a new drug (ADG126) in people with cancers that are advanced and/or have spread to other parts of the body (metastatic)

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase Ia/Ib, Open-Label, Dose-Escalation, and Dose-Expansion Study of the Anti-CTLA-4...

This phase Ia/Ib trial is evaluating how safe, tolerable and effective a new targeted therapy is, given alone or in combination with another targeted therapy, in patients with advanced cancer

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1a/1b Safety and Tolerability Study of FPT155 in Patients with Advanced Solid...

This phase I trial is evaluating the safety and recommended dose of a new intravenous drug (FPT155) in patients with advanced solid cancers (except primary CNS cancers)

Cancer type : Multi-Cancer

Systemic therapy trial

A Multi-center, Single-arm, and Open-label Phase Ib/II Study Exploring the...

This Phase I/II study is evaluating how safe and tolerable a new targeted therapy (GFH018) is in combination with a different targeted therapy (toripalimab) is in people with advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

An ascending single and multiple dose study of the safety, tolerability, pharmacokinetics...

This phase I/II study is trying to determine the best dose level, safety and tolerability of an oral targeted therapy (EO1001) in people with advanced EGFR, HER2 or HER4 positive cancer

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1/2, Open Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics and...

This phase I/II trial will begin to understand how safe and tolerable a new cancer drug (D-1553) is as a monotherapy and combination treatment for people with advanced solid cancers that have a KRasG12C mutation

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1, Open-label, Dose-escalation and Dose-expansion Study Evaluating the Safety,...

This phase I study is seeking to understand the appropriate dose level, safety and effectiveness of a new targeted therapy (D3S-001) in people with advanced solid cancers with the Kirsten rat sarcoma viral oncogene homolog gene (KRAS) p.G12C mutation

Cancer type : Multi-Cancer

Systemic therapy trial

A Multicenter, Open-label, Phase I Dose Escalation Study to Evaluate the Safety,...

This phase I study is evaluating how safe and effective a combination of two new cancer drugs (YH002 and YH001) are in people with advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

TAK-280 : A Phase 1/2, First-in-Human, Open-Label, Dose-Escalation Study of TAK-280 in Patients...

This phase I/II dose escalation and expansion study is trying to understand how safe and effective a new drug (TAK-280) is in people with locally advanced or metastatic cancer that is unable to be removed with surgery

Cancer type : Multi-Cancer

Systemic therapy trial

A First-in-Human Phase 1 Study of NL-201 in Patients With Relapsed or Refractory Cancer

This phase I trial is trying to understand how safe a new cancer immunotherapy is for the treatment of patients with advanced cancer that have not responded to or are unable to receive other treatment

Cancer type : Multi-Cancer

Systemic therapy trial

MOST-CIRCUIT : Ipilimumab and Nivolumab Combination Therapy in Patients With Selected Immunotherapy...

This phase II trial is trying to determine the clinical benefit of using two types of immunotherapy (nivolumab combined with ipilimumab) to treat neuroendocrine cancers, biliary tract cancers, gynaecological cancers and MSI-H cancers (excluding colorectal cancer)

Cancer type : Multi-Cancer

Systemic therapy trial

A Multi-center, Open-label Phase II Study to Evaluate the Safety and Efficacy of YH003 in...

This phase II study is evaluating how safe and effective a new cancer drug (YH003) is in combination with targeted therapy (toripalimab), and how these drugs combine with chemotherapy, in people with metastatic melanoma and pancreas cancer

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase I/II, First-in-Human (FIH), Open-Label, Dose Escalation and Expansion Study to...

This phase I/II study is trying to determine how safe and effective, and what the appropriate dose level of a new cancer drug (LM-108) alone, or in combination with targeted therapy (an Anti-PD-1 Antibody) in people with solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1 Dose-Escalation Study to Investigate the Safety, Efficacy, Pharmacokinetics,...

This phase I study is evaluating the effectiveness of a new targeted therapy (CLN-619) alone, and in combination with immunotherapy (pembrolizumab), in people with advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

A Multicenter, Open-Label, Phase I Dose Escalation Study to Evaluate the Safety,...

This phase I study is evaluating how safe and effective a combination of two new cancer drugs (YH003 and YH001) and immunotherapy (pembrolizumab) is in people with advanced solid cancer

Cancer type : Multi-Cancer

Systemic therapy trial

LM302 : A Phase I/II, Open-Label, Multiple Centre Clinical Study to Evaluate the Safety,...

This phase I/II trial is evaluating how safe and tolerable a new targeted therapy (LM-302) is when combined with immunotherapy (toripalimab) in people with advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

PROBE : A First-in-Human Phase I Trial of ATG-101 in Patients With Metastatic/Advanced Solid...

This phase I trial is investigating how safe and tolerable a new targeted therapy (ATG-101) is in people with metastatic or advanced solid cancers, and mature B-cell Non-Hodgkin Lymphoma

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1/2 Study of BMS-986253 in Combination With Nivolumab or Nivolumab Plus...

This phase I/II study is investigating the effects of targeted therapy (BMS-986253) in combination with immunotherapy (nivolumab and/or ipilimumab) in people with advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

KAT6 : A Phase 1 Dose Escalation and Expansion Study to Evaluate Safety, Tolerability,...

This phase I study is trying to understand how safe, tolerable and effective a new targeted therapy (PF-07248144) is alone, or combined with either hormone therapy (fulvestrant) or hormone therapy (letrozole) and another targeted therapy (palbociclib), in people with breast cancer, prostate cancer or non-small cell lung cancer

Cancer type : Multi-Cancer

Systemic therapy trial

TIGIT : Phase 1/1b Study Investigating Safety, Tolerability, PK and Antitumor Activity of...

This phase 1 trial is examining the safety and effectiveness of two targeted therapies (BGB-A1217 and Tislelizumab) for the treatment of advanced solid tumours

Cancer type : Multi-Cancer

Systemic therapy trial

TROPiCS-03 : A Phase 2 Open-Label Study of Sacituzumab Govitecan (IMMU-132) in Subjects With...

This phase II study is evaluating the effect of targeted therapy (Sacituzumab Govitecan-hziy) in people with advanced non-small cell lung cancer, head and neck squamous cell carcinoma, endometrial cancer or small cell lung cancer

Cancer type : Multi-Cancer

Multiple treatment types

COMPOSE : A Prospective, Randomised, Controlled, Open-label, Multicentre Study to Evaluate...

This phase III study is trying to understand how safe and effective radiation-based treatment (177Lu-Edotreotide PRRT) compared to best standard of care treatment in people with neuroendocrine tumours that originate in the stomach, intestines or pancreas.

Cancer type : Neuroendocrine tumours

Systemic therapy trial

A Phase I/II, Multi-center, Open Label Study of DYP688 in Patients With Metastatic Uveal...

This phase I/II study is seeking to determine the best dose level, safety and effect, of a new cancer drug (DYP688) in people with metastatic ocular (uveal) melanoma

Cancer type : Multi-Cancer

Systemic therapy trial

AKESO – AK112-01 : A Phase 1a/1b, Multicenter, Open-label, Dose-escalation and Dose-expansion Study to...

This phase 1 trial is evaluating the effectiveness and safety of a novel immunotherapy (AK112) for the treatment of patients with advanced solid tumours

Cancer type : Multi-Cancer

Systemic therapy trial

MoST addendum 19 (substudies 41-42) : Single arm, open label, signal-seeking phase II study of Sotorasib (AMG-510) in patients...

This phase II study is assessing the effect of targeted therapy (sotorasib) in adults with some advanced cancers that have KRAS G12C mutations

Cancer type : Multi-Cancer

Systemic therapy trial

MoST Addendum 14 (substudy 32) : A Single arm, open label, phase II trial of tumour response to alectinib in patients with...

This phase II study is evaluating the effect of a targeted therapy (alectinib) in people with newly diagnosed metastatic non-squamous small cell lung cancer (NSCLC) or people with advanced solid cancers with ALK gene alterations

Cancer type : Multi-Cancer

Systemic therapy trial

MoST addendum 13 (substudy 31) : A single-arm, open-label, phase II trial of the tumour response to entrectinib in...

This Phase II trial is evaluating how safe and tolerable a targeted therapy (entrectinib) is in people with newly diagnosed non-squamous non-small cell lung cancer an advanced solid cancers with NTRK fusions or ROS1 gene rearrangements

Cancer type : Multi-Cancer

Systemic therapy trial

MoST Addendum 12 (substudies 27-30) : Single arm, open label, phase II trial of vemurafenib and cobimetinib in patients with...

This phase II trial is evaluating how safe and effective a combination of two targeted therapies (vemurafenib and cobimetinib) are in people with metastatic non-squamous non-small cell lung cancer and other solid cancers with BRAF V600 mutations

Cancer type : Multi-Cancer

Systemic therapy trial

MoST 10 (substudies 23-24) : Single arm, open label, signal seeking, phase II trial of the activity of Palbociclib in...

This Phase II trial is evaluating how safe, tolerable and effective targeted therapy (palbociclib) is when combined with immunotherapy (avelumab) is in people with solid cancers with activating alterations in cell cycle genes

Cancer type : Multi-Cancer

Systemic therapy trial

MoST Addendum 9 (substudies 21-22) : Single arm, open label, signal seeking, phase II trial of the activity of tucatinib plus...

This phase II study is evaluating the effect of a combination of targeted therapies (tucatinib plus trastuzumab) in people with advanced or metastatic solid cancers with HER2 amplifications or mutations

Cancer type : Multi-Cancer

Systemic therapy trial

MoST addendum 7 (substudies 16-18) : Single arm, open label, signal seeking, phase IIa trial of the activity of Tremelimumab...

This phase II study is evaluating the effect of immunotherapy (tremelimumab) in people with advanced rare cancers

Cancer type : Multi-Cancer

Systemic therapy trial

MoST Addendum 6 (substudy 14-15) : Single arm, open label, signal seeking, phase IIa trial of the activity of Larotrectinib...

This phase II study is evaluating the effectiveness of an anticancer drug (larotrectinib) in people with advanced solid cancers with NTRK1-3 rearrangements

Cancer type : Multi-Cancer

Systemic therapy trial

MoST Addendum 4 (substudy 9) : Single arm, open label, signal seeking, phase IIa trial of the activity of vismodegib in...

This phase II study aims to assess the effectiveness of vismodegib, an oral cancer drug, in people with advanced or metastatic solid cancer with PTCH1 or SMO mutations

Cancer type : Multi-Cancer

Systemic therapy trial

STELLAR-001 : A Dose-Escalation and Expansion Study of the Safety and Pharmacokinetics of XL092 as...

This phase I study is evaluating how safe, tolerable and effective a new drug (XL092) is alone, or combined with immunotherapy (Atezolizumab or Avelumab) in people with inoperable, locally advanced or metastatic solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1, Open-Label, Dose Finding Study of CC-95251, A Monoclonal Antibody Directed...

This phase I trial is trying to determine the best dose of a drug (CC-95251) given to patients alone or in combination with one of two types of targeted cancer treatments (Rituximab or Cetuximab) in patients with advanced cancers (including advanced types of blood cancer)

Cancer type : Multi-Cancer

Systemic therapy trial

THOR-707-101 : An Open-Label, Multicenter Phase 1/2 Dose Escalation and Expansion Study of THOR-707 as a...

This phase I/II trial is testing a new intravenous drug (THOR-707) as a monotherapy (alone) and in combination with an immunotherapy in adult patients with advanced cancer that has spread to other parts of the body

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1b, Open-Label, Dose-escalation and Expansion Study to Investigate the Safety,...

This Phase I/II trial is trying to determine the safety and recommended dose of two drugs (PD-0325901 and BGB-283) given in combination for the treatment of advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

IV Sting : A Phase I First Time in Human Open Label Study of GSK3745417 Administered With and...

This phase I trial is trying to determine the recommended dose of a new intravenous therapy (GSK3745417), when given alone or in combination with a type of immunotherapy, in patients with solid cancer types

Cancer type : Multi-Cancer

Systemic therapy trial

A First-in-Human, Phase 1a/1b, Open Label, Dose-Escalation and Expansion Study to...

This Phase I trial is trying to determine how safe and tolerable a targeted therapy (BGB-3245) is in people with solid cancers with B-RAF genetic mutations.

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase Ia/Ib, Open-Label, Multicenter, Global, Dose-Escalation Study to Evaluate the...

This phase I trial is testing a new drug on its own and in combination with a type of immunotherapy in patients with advanced cancers that have spread locally or to other parts of the body

Cancer type : Multi-Cancer

Systemic therapy trial

OX40 : Phase 1 Study Investigating the Safety, Tolerability, Pharmacokinetics, and Preliminary...

This phase I trial is evaluating a new targeted therapy alone and in combination with another type of targeted therapy to see if it is safe and tolerable for advanced cancer patients

Cancer type : Multi-Cancer

Systemic therapy trial

ERASER : A Phase I, Open-Label, Multi-Center Dose Finding Study to Investigate the Safety,...

This phase I trial will test how safe and tolerable a new oral cancer drug is for the treatment of patients with advanced solid cancers or cancers of the blood

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase I Dose-Escalation and Dose-Expansion Study Evaluating the Safety,...

This phase I trial is trying to understand if a new oral drug works and is safe for the treatment of advanced KRAS G12C mutated solid cancers that have spread to other parts of the body

Cancer type : Multi-Cancer

Systemic therapy trial

TAILOR : Safety and Oversight of the Individually Tailored Treatment Approach: A Novel Pilot...

This trial is evaluating individually tailored treatment plans in people with advanced cancers who are accessing targeted therapy cancer drugs through compassionate access

Cancer type : Multi-Cancer

Systemic therapy trial

PETRA : A Modular Phase I/IIa, Open-label, Multicentre Study to Assess the Safety, Tolerability,...

This Phase I/II trial is trying to determine how safe, tolerable and effective a targeted cancer drug (AZD5305) is alone, or in combination with chemotherapy (paclitaxel and carboplatin) in people with advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

TAPISTRY : Tumor-Agnostic Precision Immunooncology and Somatic Targeting Rational for You (TAPISTRY)...

This phase II trial has been designed to evaluate the safety and effectiveness of using targeted therapies or immunotherapy as a single agent or combination treatment in patients with advanced solid tumours that have specific genetic alteration(s)

Cancer type : Multi-Cancer

Systemic therapy trial

Master Protocol to Assess the Safety and Recommended Phase 2 Dose of Next Generations of...

This Phase I trial is trying to understand the safety and effectiveness of targeted immunotherapy people with previously untreated synovial sarcoma and/or non-small cell lung cancer

Cancer type : Multi-Cancer

Systemic therapy trial

Vivace : Phase 1, Multi-Center, Open-Label, Study to Evaluate the Safety, Tolerability, and PK of...

This Phase I trial is trying to understand how safe and tolerable a targeted therapy drug (VT3989) is in people with advanced pleural malignant mesothelioma or other metastatic solid tumours

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase Ib/II Open-label, Multi-center Dose Escalation Study of JDQ443 in Patients With...

This Phase Ib/II trial is seeking to determine the recommended dose, and then the safety and effectiveness, of a new targeted therapy (JDQ443) alone, and in combination with other targeted therapies (TNO155 and spartalizumab) in people with advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1 Study Investigating the Safety, Tolerability, Pharmacokinetics, and Preliminary...

This Phase I trial is trying to understand how safe and tolerable a targeted therapy (BGB-15025) alone and in combination with another targeted therapy (tislelizumab) in people with advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase I/IIa Multi-center, Open-label Master Protocol to Evaluate the Safety,...

This phase I/II study is evaluating how safe, tolerable and effective a new cancer drug (AZD8205) is in people with advanced or metastatic solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

CRESTONE : CRESTONE: A Phase 2 Study of Seribantumab in Adult Patients With Neuregulin-1 (NRG1)...

This phase II trial is trying to understand the effectiveness of a targeted therapy (Seribantumab) in adults with Neuregulin-1 (NRG1) Fusion Positive, locally advanced or metastatic, solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

IMPARP-HRD : An Open Label, Signal Seeking, Translational, Phase II Trial of Pamiparib in Combination...

This phase II study is evaluating how effective a combined treatment of two targeted therapies (pamiparib and tislelizumab) in people with advanced cancers that have molecular profiles consistent with homologous recombination deficiency (HRD)

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1, Multicenter, Open-Label, First-in-Human Study of the Safety and...

This phase I study is evaluating how safe and effective a new targeted therapy (AMX 818) is alone, or in combination with immunotherapy (pembrolizumab) in people with HER2+ cancers

Cancer type : Multi-Cancer

Systemic therapy trial

An Open-label, Multicenter, Phase I Study to Evaluate Safety, Pharmacokinetics, and...

This phase I dose escalation and dose expansion study is evaluating a new cancer drug (RO7444973) in people with inoperable or metastatic solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1 Study Investigating the Safety, Tolerability, Pharmacokinetics,...

This phase I study is evaluating how safe, tolerable and effective a new cancer drug (BGB-24714) is alone, and in combination with chemotherapy (paclitaxel) in people with advanced or metastatic solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1/2 Study of PBI-200 in Subjects With NTRK-Fusion-Positive Advanced or Metastatic...

This phase I/II study is evaluating how safe, tolerable and effective a new targeted therapy (PBI-200) is in people with NTRK-fusion-positive advanced or metastatic solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1a/1b Study Investigating the Safety, Tolerability, Pharmacokinetics,...

This phase I study is evaluating how safe, tolerable and effective a new cancer drug (BGB-B167) is alone, and in combination with targeted therapy (tislelizumab) in people with advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1 First-in-Human Study With ABBV-155 Alone and in Combination With Taxane Therapy...

This phase I study is assessing how safe and effective a new targeted therapy (ABBV-155) is alone, or in combination with chemotherapy (paclitaxel or docetaxel), in people with small cell lung cancer, non-small cell lung cancer or breast cancer

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase I/II, First-in-Human, Open-Label, Multicenter Study Evaluating the Safety,...

This phase I/II study is trying to determine the appropriate dose level, and safety, of a new targeted therapy (GB263T) in people with advanced solid cancer, including non-small cell lung cancer

Cancer type : Multi-Cancer

Systemic therapy trial

BGB-290-AU-102 : Phase 1-2 Study Investigating Safety, Tolerability, Pharmacokinetics and Preliminary...

This phase I/II trial is evaluating the safety and recommended dose of a combined targeted therapy (BGB-A425 and Tislelizumab) in patients with advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

MT-5111 : A Phase 1 Open-label, Multicenter Dose Escalation and Expansion Study of MT-5111 in...

This phase I/II is investigating the appropriate dose level and effectiveness of a new cancer drug (MT-5111) in people with HER2-positive solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

MK-1084 : A Phase 1, Open-Label, Multicenter Study to Assess Safety, Tolerability, PK, and Efficacy...

This phase I trial is evaluating how safe and effective targeted therapy (MK-1084) is alone in people with advanced solid cancers with KRASG12C mutation, and when it is combined with immunotherapy (pembrolizumab) in people with non-small cell cancer with KRASG12C mutation

Cancer type : Multi-Cancer

Systemic therapy trial

A Multicenter, Open-Label, Phase I/II Dose Escalation and Expansion Study to Evaluate the...

This phase I/II trial is exploring increasing doses of a new cancer drug (YH003) in combination with a targeted therapy with the aim of identifying and evaluating maximum tolerated/recommended dose

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1/2, First-in-Human, Open Label, Dose Escalation and Expansion Study of AU-007, A...

This phase I/II trial is trying to understand how safe, tolerable and effective a targeted therapy (AU-007), with or without immunotherapy (aldesleukin), is in people with advanced or metastatic solid cancer

Cancer type : Multi-Cancer

Radiotherapy trial

PARLuNET : Phase 1 Trial of PARP Inhibitor Combined With 177Lu-DOTA-Octreotate Peptide Receptor...

This phase I trial is evaluating how safe and tolerable a targeted therapy (talazoparib) is in combination with radionuclide therapy (177Lu-DOTA-Octreotate) in people with metastatic pancreatic neuroendocrine cancer

Cancer type : Multi-Cancer

Multiple treatment types

SABR-COMET 10 : A Randomized Phase III Trial of Stereotactic Ablative Radiotherapy for the Comprehensive...

This Phase III study is trying to understand the impact of Stereotactic Ablative Radiotherapy (SABR), compared to standard of care treatments in people with 4 to 10 metastatic cancer deposits

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1 Multi-Country, Multi-Center, Open-Label Study to Evaluate the Safety,...

This phase I trial is evaluating how safe, tolerable and effective a targeted therapy (SHR-A1811) is in people with HER2 expressing or mutated advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

NEON-1 : An Open-label Study of ALPN-202 in Subjects With Advanced Malignancies (NEON-1)

This Phase I trial is evaluating a targeted therapy (ALPN-202) in people with advanced solid cancers, or refractory lymphoma.

Cancer type : Multi-Cancer

Surgical trial

VAPOR-C : Volatile Anaesthesia and Perioperative Outcomes Related to Cancer: The VAPOR-C Trial

This study aims to understand the impact of anaesthesia on duration of disease free survival in patients undergoing surgery for colorectal or non-small cell lung cancer

Cancer type : Multi-Cancer

Systemic therapy trial

NORTH : A Phase II Study of Panobinostat in Paediatric, Adolescent and Young Adult Patients with...

This phase II trial is testing the effectiveness of a new oral drug (Pabinostat) in paediatric and adult patients who have an osteosarcoma, rhabdoid tumour and/or neuroblastoma that has gotten worse or not responded to prior treatment

Cancer type : Multi-Cancer

Systemic therapy trial

KEYLYNK-007 : A Phase 2 Study of Olaparib in Combination With Pembrolizumab in Participants With...

This phase II trial is trying to determine the safety and effectiveness of a targeted treatment (Olaparib) in combination with an immunotherapy (Pembrolizumab) in adult patients who have previously been treated for advanced HRRm and/or HRD+ tumours

Cancer type : Multi-Cancer

Systemic therapy trial

CPI-006-001 : A Phase 1/1b Multicenter Study To Evaluate The Humanized Anti-CD73 Antibody, CPI-006, As...

This phase I/Ib trial is comparing a new immunotherapy agent (CPI-006) alone and in combination with two other therapies (CPI-444 and pembrolizumab) in adults diagnosed with select advanced cancers

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1a/1b, Multicenter, Open-Label, Dose-Escalation and Dose-Expansion Study to...

This phase I trial is evaluating how safe and tolerable a new biological therapy (AK127) in combination with another biological therapy (AK104 or cadonilimab) in patients with advanced or metastatic solid cancers (excluding some blood cancers)

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1/2, Dose Escalation and Expansion Study of BGB-10188, a Phosphatidylinositol...

This phase I/II trial is testing how safe and tolerable a new targeted cancer therapy is for the treatment of patients with mature B-cell blood cancer (when given in combination with the standard targeted therapy, zanubrutinib) or for patients with a type of advanced cancer (given in combination with the standard targeted therapy, tislelizumab)

Cancer type : Multi-Cancer

Systemic therapy trial

EZ7438 : An Open-Label, Multicenter, Phase 1/2 Study of E7438 (EZH2 Histone Methyl Transferase...

This phase I/II trial is evaluating an oral drug (tazemetostat) alone and in combination with a steroid (prednisolone) for the treatment of advanced solid cancers and patients with B Cell Lymphoma

Cancer type : Multi-Cancer

Systemic therapy trial

WM-S1-030 : A Phase I, Open-label, Multicenter, Dose-escalation and Dose-expansion Study to...

This Phase I trial is evaluating how safe and tolerable a targeted therapy drug (WM-S1-030) is in people with advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1 First In Human Study Evaluating Safety And Efficacy Of ABBV-637 As Either...

This Phase I trial is evaluating how safe and tolerable a new cancer drug (ABBV-637) is alone, or in combination with chemotherapy (docetaxel) or targeted therapy (osimertinib) in in people with relapsed or refractory solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1a/b, open-label, dose-exploration, combination/ expansion study to evaluate the...

This Phase I trial is evaluating how safe and effective different doses of a new targeted cancer drug (Auceliciclib) is in people with advanced solid cancers, or when given in combination with chemotherapy (temozolomide) in people with glioblastoma multiforme

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1/2 First-in-Human Study of BMS-986249 Alone and in Combination With Nivolumab in...

This phase I/II trial is trying to determine whether it is safe to give the study drug (BMS-986249), alone and in combination with an immunotherapy (Nivolumab), to patients with advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

PIVOT IO 020 : Phase 1/2 Study of Bempegaldesleukin in Combination With Nivolumab in Children,...

This phase I/II study is evaluating how safe and effective a combined treatment of targeted therapy (Bempegaldesleukin) and immunotherapy (Nivolumab) in children, adolescents and young adults with recurrent or treatment-resistant cancers

Cancer type : Multi-Cancer

Systemic therapy trial

iMATRIX : A Phase I/II, Open-Label, Multicenter, Study Evaluating the Safety, Pharmacokinetics, and...

This phase I/II trial is evaluating how safe and tolerable targeted therapy (alectinib) is in children and adolescents with Anaplastic Lymphoma Kinase (ALK) fusion-positive solid cancers or cancers of the brain or spinal cord

Cancer type : Multi-Cancer

Systemic therapy trial

AGCT1531 : A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin...

This phase III trial is evaluating how well active surveillance and four different chemotherapy drugs (bleomycin, carboplatin, etoposide, or cisplatin) work in treating paediatric or adult patients with germ cell tumours

Cancer type : Multi-Cancer

Systemic therapy trial

APG-115-US-002 : A Phase Ib/II Study of APG-115 in Combination With Pembrolizumab in Patients With...

This phase I/II trial is trying to understand the best dosage level, safety and effectiveness of a new targeted therapy (APG-115) when combined with immunotherapy (pembrolizumab) in people with solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

PROPEL : A Phase 1/2, Open-Label, Multicenter Study to Investigate the Safety and Preliminary...

This phase I/II trial is trying to understand how safe and well tolerated a new immunotherapy is when combined with a standard immunotherapy drug in patients with advanced cancer

Cancer type : Multi-Cancer

Systemic therapy trial

Phase 1 Pharmacodynamic and Pharmacokinetic Study of the Geranylgeranyltransferase I...

This phase I trial is evaluating an intravenous drug (PTX-100) in people with an advanced cancer

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1b Dose-Escalation Study of Cabozantinib (XL184) Administered Alone or in...

This phase Ib trial is trying to understand how safe and tolerable a type of targeted therapy is for the treatment of several different types of cancer

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1 Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics,...

This trial is measuring the safety and maximum tolerated dose of a new experimental cancer drug (BNA035) in people with advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

MoST Addendum 8 : Single arm, open label, signal seeking, phase IIa trial of the activity of Trastuzumab...

This Phase II study is trying to understand how effective a targeted therapy (trastuzumab emtansine) is in people with cancers with HER2 amplifications or mutations

Cancer type : Multi-Cancer

Systemic therapy trial

ICP-CL-00303 : A Multi-center Open-label, Phase I/II Clinical Trial to Evaluate the Safety,...

This Phase I/II trial is evaluating how safe and tolerable a new targeted therapy (ICP-192) is in people with advanced solid cancers, gall bladder cancer or bladder cancer

Cancer type : Multi-Cancer

Systemic therapy trial

Epimab : A Phase I/II Trial of EMB-02, a Bi-specific Antibody Against PD-1 and LAG-3, in Patients...

This Phase I/II trial is trying to determine the recommended dose, safety and tolerability of a new targeted therapy (EMB-02) in people with advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

TCTLR : Phase 1/2, Open-label, Dose Escalation and Dose Expansion Study of TransCon TLR7/8...

This Phase I/II trial is trying to evaluate how safe and tolerable a new cancer drug (TransCon TLR7/8 Agonist) alone, and in combination with immunotherapy (Pembrolizumab) in people with advanced or metastatic solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

IMPACT : A Phase I, Open-Label, Multi-Center, Dose Escalation and Expansion Study to Evaluate...

This phase I trial will begin to understand how safe and tolerable a combination therapy (containing a new cancer drug, IMP4297, and a type of chemotherapy) is in people diagnosed with advanced solid cancer, including small cell lung cancer

Cancer type : Multi-Cancer

Systemic therapy trial

SPARTA : Phase 1 / 2 Multicenter Study of the Safety, Pharmacokinetics, and Preliminary Efficacy...

This trial is trying to understand how safe and tolerable a new oral treatment (APL-101) is for patients with non-small cell lung cancer and other advanced cancers

Cancer type : Multi-Cancer

Systemic therapy trial

A First-in-Human Dose Escalation and Expansion Study to Evaluate Intratumoral...

This Phase I trial is evaluating appropriate dosing levels of an intratumoral therapy (within a tumour) alone, and in combination with immunotherapy (pembrolizumab) in people with advanced solid cancers

Cancer type : Multi-Cancer

Systemic therapy trial

Open Label, Phase Ib Study to Evaluate the Safety, Tolerability, Pharmacokinetics and...

This Phase I trial is trying to understand how safe and effective a targeted therapy (CYH33) is in combination with chemotherapy (olaprib) is in people with advanced solid cancers that have DDR gene mutations and/or PIK3CA mutations

Cancer type : Multi-Cancer

Systemic therapy trial

COBRA : A Phase 1/2, First-in-Human, Open Label, Dose Escalation Study of MVC-101, An EGFR x CD3...

This trial is trying to understand how safe, well tolerated and effective a new targeted cancer drug is in patients with squamous cell carcinoma of the head and neck, non-small cell lung cancer or colorectal cancer

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase I, Open-Label, Multiple Ascending Dose Study of the Safety and Tolerability of...

This Phase I trial is trying to understand how safe and tolerable a targeted therapy (T3011) is in people with advanced cancers

Cancer type : Multi-Cancer

Systemic therapy trial

An Open-Label, Multicenter Phase 2 Basket Study to Evaluate the Antitumor Activity and...

This study is evaluating how safe a type of targeted therapy (Lenvatinib) is for the treatment of children, adolescents, and young adults with relapsed or refractory cancer

Cancer type : Multi-Cancer

Systemic therapy trial

INFORM2 NivEnt : INFORM2 Exploratory Multinational Phase I/II Combination Study of Nivolumab and...

This study aims to analyse the effectiveness of combined treatment in children and adolescents with certain high risk refractory, relapsed or progressive cancer

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1/2 Study of ALKS 4230 Administered Intravenously as Monotherapy and in...

This phase I/II trial is trying to understand how safe and tolerable a new immunotherapy is for the treatment of advanced cancer

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1a/1b, Multicenter, Open-Label, Dose-Escalation and Dose-Expansion Study to...

This phase I trial is trying to understand how safe a new targeted cancer therapy is, and how much of it to use, as a combination treatment for patients with advanced solid cancers that have spread to other parts of the body

Cancer type : Multi-Cancer

Systemic therapy trial

LEAP-005 : A Multicenter, Open-label Phase 2 Study of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab...

This Phase II trial is trying to determine how safe and effective a combination therapy (with pembrolizumab and lenvatinib) is in treating patients with select advanced cancers

Cancer type : Multi-Cancer

Systemic therapy trial

ABBV-927 : A Multi-Center, Phase 1, Open-Label, Dose-Escalation Study of ABBV-927, an...

This phase I trial is evaluating ABBV-927 (an immunotherapy) alone and in combination with nivolumab for the treatment of advanced cancer

Cancer type : Multi-Cancer

Systemic therapy trial

LIBRETTO-121 : A Phase 1/2 Study of the Oral RET Inhibitor LOXO 292 in Pediatric Patients With Advanced...

This phase I/II trial is testing a new oral cancer drug (LOXO-292) for the treatment of children that have advanced solid- or primary central nervous system- cancer

Cancer type : Multi-Cancer

Systemic therapy trial

AMG144 : A Phase 1 Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics...

This phase I trial is trying to understand whether a new intravenous drug is safe and tolerable for the treatment of patients with advanced cancer

Cancer type : Multi-Cancer

Systemic therapy trial

M16-438 : A Phase 1 Study Evaluating the Safety, Pharmacokinetics, and Anti-tumor Activity of...

This Phase I trial is evaluating an intravenous drug (ABBV-321) in patients with advanced cancers that are associated with EGFR overexpression

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase Ib, Open-label Clinical Study to Evaluate the Safety, Tolerability,...

This phase I trial is evaluating how safe and tolerable a new oral drug (IN10018) is, when it is given on it's own and in combination with an oral targeted therapy, for patients with uveal or NRAS-mutant melanoma that has spread to other parts of the body

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1/2A Trial of ENB 003 in Combination With Pembrolizumab in Subjects With Advanced...

This phase I/II trial is testing how safe ENB003 is as a treatment for select solid cancers, and how well it is tolerated in patients, when given alone or in combination with a type of immunotherapy (Pembrolizumab)

Cancer type : Multi-Cancer

Systemic therapy trial

MK-0482-001 : A Phase 1b, Open-Label, Dose Escalation Study to Evaluate the Safety, Tolerability,...

This phase 1 trial is evaluating the safety and effectiveness of a novel biological therapy (MK-0482) alone and in combination with a targeted therapy (pembrolizumab) to treat patients with advanced solid tumours

Cancer type : Multi-Cancer

Systemic therapy trial

MK-7684-001 : A Phase 1 Trial of MK-7684 as Monotherapy and in Combination With Pembrolizumab in...

This phase I trial is evaluating a new immunotherapy drug (MK-7684) alone and in combination with another immunotherapy drug (Pembrolizumab) in patients with advanced solid tumours

Cancer type : Multi-Cancer

Systemic therapy trial

A Phase 1 Open Label, Multi-Arm, Multicenter Study of MK-1308 in Combination With...

This phase I trial is evaluating the safety and effectiveness of increasing doses of an immunotherapy drug (MK-1308) given in combination with another immunotherapy drug (Pembrolizumab) for the treatment of patients with advanced solid tumours

Cancer type : Multi-Cancer

Systemic therapy trial

FPA150-001 : A Phase 1a/1b Study of FPA150, an Anti-B7-H4 Antibody, in Patients With Advanced Solid...

This early phase I trial is evaluating the safety and effectiveness of a new immunotherapy (Anti-B7-H4 Antibody, FPA150) alone and in combination with another type of immunotherapy (Pembrolizumab) in patients with select advanced cancers

Cancer type : Multi-Cancer

Systemic therapy trial

The Carolyn Trial (ENG9) : A Phase I/IIa Study of EGFR-Targeted EDVTMs Carrying the Cytotoxic Drug PNU-159682...

This phase I/II trial is evaluating the safety and effectiveness of a combination treatment for patients with advanced pancreatic cancer or other EGFR expressing cancers

Cancer type : Multi-Cancer

Systemic therapy trial

M13-833 : A Phase 1 Study of the Safety and Pharmacokinetics of Venetoclax in Pediatric and Young...

This phase I trial is evaluating an oral drug (venetoclax) with or without chemotherapy in children and young adults with relapsed or refractory malignancies

Cancer type : Multi-Cancer

Systemic therapy trial

CT952 : A Phase 1, Open-label, Multicenter, Dose-escalation Study of CK-301 Administered...

This phase I trial is evaluating an intravenous drug (CK-301) in patients with select advanced cancers

Cancer type : Multi-Cancer

Radiotherapy trial

SHRINC : A Phase II Prospective Trial of Stereotactic Hypofractionated Radiation for Multiple...

This phase II trial is assessing a type of radiotherapy treatment for patients whose cancer has spread to the brain

Cancer type : Multi-Cancer

Systemic therapy trial

APG-1387 : A phase 1, open label, multi-center, dose escalation study of the safety, tolerability,...

This phase I trial is evaluating an intravenously (in the vein) administered drug (APG-1387) in patients with advanced solid cancers or Lymphoma

Cancer type : Multi-Cancer

Systemic therapy trial

KEYNOTE-240 : A Phase III Study of Pembrolizumab (MK-3475) vs. Best Supportive Care as...

This phase III trial is evaluating pembrolizumab in patients who have previously received systemic treatment for advanced hepatocellular (liver) cancer

Cancer type : Liver

Systemic therapy trial

KEYNOTE-051 : A Phase I/II Study of Pembrolizumab (MK-3475) in Children With Advanced Melanoma or a...

This phase I/II trial is evaluating pembrolizumab (an immunotherapy drug) in children with advanced Melanoma, PD-L1 positive solid cancer or Lymphoma

Cancer type : Multi-Cancer

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