Trial purpose
Cancer treatment
Tumor type
Upper gastrointestinal tract
Age
18+
Clinical summary
Summary
The purpose of this research study is to investigate the safety of an active implantable (radiological) medical device OncoSil™ when implanted into patients with pancreatic cancer, in conjunction with Standard of Care (SOC)chemotherapy. OncoSil™ is an experimental treatment and carries the active treatment "radioactive Phosphorous (32P)" inside inactive silicon particles. Once implanted, the OncoSil™ Microparticles will stay in the tumour permanently. The purpose of OncoSil™ is to deliver the action of 32P directly into a targeted tumour to destroy cancer cells. Everyone in the research study will receive the investigational treatment OncoSil™, plus their prescribed standard chemotherapy regimen which will be either; FOLFIRINOX (FOLFIRINOX is the name of a combination of chemotherapy drugs used to treat advanced cancer of the pancreas) or gemcitabine + nab-paclitaxel (Abraxane). Screening, Follow Up Period and Long Term follow up is required. The total number of visits patients will need to attend will depend on how long it takes for their disease to progress.
Conditions
This trial is treating people with Pancreatic Cancer
Eligibility
Inclusion
- Histologically or cytologically proven adenocarcinoma of the pancreas.
- Unresectable locally advanced pancreatic carcinoma. Patients with technically resectable tumours (T1-T3) will also be eligible, if they are deemed unresectable due to medical comorbidities or refusal of surgery.
- Pancreatic target tumour diameter of ≥ 2.0 cm (shortest axis) to ≤ 6.0 cm (longest axis), as qualified by the central reading centre.
- An ECOG Performance Status of 0 to 1 and Karnofsky Performance Status of 80 - 100.
- Study participants ≥ 18 years of age at screening.
- To commence first-line standard FOLFIRINOX or gemcitabine+nab-paclitaxel chemotherapy (per standard of care according to the approved prescribing schedule), within 14 days post enrolment, with OncoSil™ implantation to occur during the fourth (4th) week of the first chemotherapy cycle.
- Provide signed Informed Consent.
- Willing and able to complete study procedures within the study timelines.
- Adequate renal function: serum creatinine less than 1.5 x upper limit of normal (ULN).
-
Adequate liver function: serum liver transaminases ≤ 3 × ULN and serum bilirubin
≤ 1.5 × ULN*.
*For study participants with recent biliary obstruction treated by drainage (e.g. stent), serum bilirubin of > 1.5 x ULN will be accepted for study entry provided that serial levels demonstrate clear improvement. In addition, chemotherapy should not be commenced until serum bilirubin is ≤ 1.5 × ULN.
- Adequate bone marrow function: white blood cells (WBCs) ≥ 3,000/mm3, absolute neutrophil count (ANC) ≥ 1,500/mm3, haemoglobin ≥ 9 g/dL, and platelets ≥ 100,000/mm3.
- Life expectancy of at least 3 months at the time of screening as judged by the investigator.
- Treated with or eligible to commence prophylactic treatment with a proton-pump inhibitor prior to implantation, and to continue to receive treatment for at least 6 months post implantation.
- Not pregnant, and if of childbearing potential, agrees to use adequate birth control (hormonal or barrier method of birth control or abstinence) prior to study entry and during the study and agrees not to donate sperm or ova, for the duration of the study and 12 months post implantation of the investigational device.
Exclusion
- Evidence of distant metastases, based on review of baseline CT scan, as determined by the central reading centre.
- More than one primary lesion.
- Any prior radiotherapy or chemotherapy for pancreatic cancer.
- Use of other investigational agent at the time of screening, or within 30 days or five half-lives of Screening Visit 1, whichever is longer.
- Pregnant or lactating.
-
In the opinion of the investigator, EUS directed implantation posing undue study participant risk. This includes:
- where previous EUS-FNA was considered technically too difficult to perform;
- imaging demonstrates multiple collateral vessels surrounding or adjacent to the target tumour within the pancreas;
- presence (or significant risk) of varices near to the target tumour. Note: The feasibility of implantation of the target tumour and assessment of risk can be conducted at any time between Screening Visit 1 and the implantation date. A study participant should be considered for withdrawal prior to and including at the time of OncoSil™ treatment, if any of the above risk features become apparent following subject screening and/or enrolment.
- History of malignancy, treated or untreated, within the past five years whether or not there is evidence of local recurrence or metastases, with the exception of basal cell carcinoma of the skin and cervical carcinoma in situ.
- Evidence of radiographic invasion into stomach, duodenum or peritoneum (if not certain confirmation must be obtained prior to enrolment).
- A known allergy or history of hypersensitivity to silicon, phosphorous or any of the OncoSil™ components.
- Any other health condition that would preclude participation in the study in the judgment of the investigator.
Note: T1-T3 is determined as per The American Joint Committee on Cancer (AJCC) tumor/node/metastasis (TNM) classification and staging system for pancreatic cancer
Exclusion
- You have been diagnosed with a prior or secondary type of cancer.
- You have certain types of non-cancer medical conditions.
- You are currently being treated on a clinical trial.
Clinical trials have complex eligibility criteria, and other criteria may apply for this trial. Ask your doctor about whether this trial could be right for you.
More information
Trial Identifiers
Information on this page is partially produced from ClinicalTrials.gov *. View further details about this trial on the registry via the links below:
Trial sponsor
OncoSil Medical Ltd
Scientific Title
An Open Label, Single Arm Pilot Study of OncoSil™ Administered to Study Participants With Unresectable Locally Advanced Pancreatic Adenocarcinoma, Given in Combination With FOLFIRINOX or Gemcitabine+Nab-paclitaxel Chemotherapies
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