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RecruitingLast updated: 19 May 2026

Studying a new drug (called RO7851624) in people with relapsed or refractory multiple myelomaAn Open-Label, Multicenter, Phase Ia/b Study Evaluating the Safety and Pharmacokinetics of RO7851624 in Patients With Relapsed/Refractory Multiple Myeloma

Trial purpose

Medical clipboardCancer treatment

Tumor type

Blood Cancers Haematological

Age

People18+

Clinical summary

Summary

This study is looking at how safe the drug RO7851624 is, how the body processes it, and how well it works in people with relapsed or refractory multiple myeloma (RRMM).

It is for people who have already been treated with the main types of myeloma medicines (including proteasome inhibitors, immunomodulators, and anti-CD38 antibody treatments), and whose disease has come back or stopped responding. These participants may also have limited standard treatment options remaining due to side effects, lack of response, or having received many prior treatments.

Conditions

This trial is treating people with multiple myeloma

Eligibility

Inclusion

  • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1.
  • Life expectancy of at least 12 weeks.
  • Diagnosis of multiple myeloma per International Myeloma Working Group (IMWG) criteria.
  • Measurable disease.

Exclusion

  • Treatment with any chemotherapeutic agent, or treatment with any other anti-cancer agent (investigational or otherwise) with insufficient washout prior to first dose of study treatment.
  • Autologous stem cell transplant (SCT) with insufficient time prior to first dose of study treatment.
  • Prior allogeneic SCT.
  • Prior solid organ transplantation.

Inclusion

  • You have had treatment, but your cancer has come back (relapsed or recurrent).
  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
  • You have had a certain type of treatment or surgical procedure.
Message

Clinical trials have complex eligibility criteria, and other criteria may apply for this trial. Ask your doctor about whether this trial could be right for you.

Participating hospitals

Recruiting hospitals

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More information

Trial Identifiers

Information on this page is partially produced from ClinicalTrials.gov *. View further details about this trial on the registry via the links below:

Trial sponsor

Genentech, Inc.

Scientific Title

An Open-Label, Multicenter, Phase Ia/b Study Evaluating the Safety and Pharmacokinetics of RO7851624 in Patients With Relapsed/Refractory Multiple Myeloma

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