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RecruitingLast updated: 6 August 2026

Assessing a new medicine called GSK5471713 for people with metastatic castration-resistant prostate cancer (mCRPC)A Phase 1/2 First-Time-in-Human, Open-label, Multicenter, Dose Escalation and Dose Optimization Study of GSK5471713 in Adult Participants With Metastatic Castration Resistant Prostate Cancer (mCRPC)

Trial purpose

Medical clipboardCancer treatment

Tumor type

Urinary System Cancers Genitourinary

Age

People18+

Clinical summary

Summary

This trial is testing a medicine called GSK5471713 for people with metastatic castration-resistant prostate cancer (mCRPC).

The purpose of the study is to find out:

  • How safe the medicine is and what side effects it may cause
  • How well people tolerate the treatment
  • How the medicine moves through and is processed by the body
  • Whether the medicine shows signs of helping to control or treat prostate cancer
  • What the potential benefits and risks of treatment are

You may be eligible for this study if you have metastatic castration resistant prostate cancer (mCRPC) that has worsened despite androgen deprivation therapy (ADT). Participants must have previously received at least one androgen receptor pathway inhibitor (ARPI) and one or two taxane-based chemotherapy treatments.

Participants will receive GSK5471713 on its own. Different dose levels of the medicine will be tested, with participants receiving different doses to help researchers identify a safe and appropriate dose for future studies.

Conditions

This trial is treating people with metastatic castration-resistant prostate cancer

Eligibility

Inclusion

  • Participants with mCRPC that have histologically or cytologically confirmed adenocarcinoma of the prostate.
  • Participants with mCRPC that has prostate cancer progression while on Androgen deprivation therapy (ADT).
  • Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 or 1.
  • Progression on ADT and >=1 prior Androgen receptor pathway inhibitors (ARPI) for Hormone-Sensitive Prostate Cancer (HSPC) or Castration resistant prostate cancer (CRPC) and received 1-2 prior taxane based chemotherapy regimens.

Exclusion

  • Pathological finding consistent with small cell, neuroendocrine carcinoma of the prostate, or any histology different from adenocarcinoma.
  • Impaired cardiac function or clinically significant cardiac disease.
  • Any significant medical condition, such as uncontrolled infection or clinically significant laboratory abnormality.
  • Prior therapy with Androgen receptor (AR) Degrader targeted therapy. Other protocol-defined inclusion/exclusion criteria apply.

Inclusion

  • Your cancer has spread to other parts of the body (metastatic) or has grown into nearby parts of the body (locally advanced).
  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
  • You have had a certain type of treatment or surgical procedure.

Exclusion

  • You have certain types of non-cancer medical conditions.
  • You have had certain treatments, surgical procedures or drugs.
Message

Clinical trials have complex eligibility criteria, and other criteria may apply for this trial. Ask your doctor about whether this trial could be right for you.

Participating hospitals

Recruiting hospitals

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More information

Trial Identifiers

Information on this page is partially produced from ClinicalTrials.gov, EU Clinical Trials Register *. View further details about this trial on the registry via the links below:

Trial sponsor

GlaxoSmithKline

Scientific Title

A Phase 1/2 First-Time-in-Human, Open-label, Multicenter, Dose Escalation and Dose Optimization Study of GSK5471713 in Adult Participants With Metastatic Castration Resistant Prostate Cancer (mCRPC)

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