Summary
The purpose of this study is to learn more about a new medicine called PF-08634404, and how well it works in people with cancer of the colon or rectum (CRC). The goal is to understand if the new study medicine, combined with chemotherapy that is approved for colorectal cancer, can help people whose cancer has spread or returned after treatments taken before.
To join the study, participants must meet the following conditions:
- Be 18 years or older.
- Have colorectal cancer that has spread to other parts of your body (metastatic).
- Be in good enough health to receive study treatment.
- Should not be pregnant before starting treatment.
Participants will be randomised (by chance, like flipping a coin) to one of two different treatment arms.
- Arm A: includes the new medicine PF-08634404 in combination with chemotherapy
- Arm B: includes an approved medicine for colorectal cancer, called bevacizumab, in combination with chemotherapy.
Participants and their doctors will not know which arm they are being assigned to. Participants will receive all the study medications through intravenous (IV) infusion, which means the medicine is given directly into a vein. The treatment will be given in cycles, and participants may continue receiving it if it is helping and they are not experiencing serious side effects.
The medication will be given at a clinical site, where trained medical staff will check participants during and after each treatment.
- The study is expected to last approximately 33 months for each participant.
- Participants will have regular visits to the study site for treatment, health checks, and tests.
- After stopping treatment, participants will return for a final visit about 30 to 37 days later to check their health and review any side effects.
- Follow-up will continue every 12 weeks by phone or in person, or by reviewing health records to check on health status and any new treatments.