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RecruitingLast updated: 7 August 2026

CERPASS LTFU: A long-term follow-up study for people who have previously received an RPx treatment in a Replimune clinical trial. Researchers will monitor participants' health over time to better understand the long-term safety of the treatment.Long-term Safety Outcomes in Patients Treated With Replimune Oncolytic Immunotherapy Products

Trial purpose

Medical clipboardLong-term follow-up

Tumor type

Multi-Cancer Multi-Cancer

Age

People18+

Trial acronym

CERPASS LTFU

Clinical summary

Summary

This study is for people who have previously taken part in a Replimune clinical trial and received at least one dose of an RPx treatment.

The purpose of this study is to monitor participants' health over a longer period to identify any side effects that may develop after treatment has finished. No study treatment will be given as part of this follow-up study.

Participants will be followed for up to 5 years after joining the study. During this time, the study team will check for any new health issues that may be related to the RPx treatment, including:

  • new cancers
  • new or worsening nerve and brain conditions
  • new or worsening autoimmune conditions
  • blood disorders
  • infections that may be related to the RPx treatment, including herpes-like infections.

If a participant develops a suspected herpes-like infection, they may be asked to provide a swab from the affected area. They may also be asked to provide additional samples, such as blood or urine, to help researchers understand whether the RPx treatment is present.

Participants will be contacted every 3 months for 5 years. Follow-up appointments may take place in person, by phone, by video call, or using another approved technology.

Taking part in this study helps researchers better understand the long-term safety of RPx treatments.

Conditions

This trial is treating people with previous experience in a Replimune clinical trial who have taken RPx treatment

Eligibility

Inclusion

Patients are eligible for inclusion in the study only if they meet all of the following criteria:

  1. Patient has received at least 1 dose of an RPx product and has completed or discontinued participation in the parent study.
  2. Patient or patient's legal guardian has provided signed informed consent (or assent) as , which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.

Exclusion

Patients are excluded from the study if the following criterion applies:

1. Cannot comply with the requirements of the study.

Inclusion

  • You have previously participated in a certain specific clinical trial.
  • You have had a certain type of treatment or surgical procedure.
Message

Clinical trials have complex eligibility criteria, and other criteria may apply for this trial. Ask your doctor about whether this trial could be right for you.

Participating hospitals

Recruiting hospitals

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More information

Trial Identifiers

Information on this page is partially produced from ClinicalTrials.gov *. View further details about this trial on the registry via the links below:

Trial sponsor

Replimune, Inc.

Scientific Title

Long-term Safety Outcomes in Patients Treated With Replimune Oncolytic Immunotherapy Products

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