SENTI-202-101: This is a dose-finding study of SENTI-202, a type of immunotherapy called CAR NK Cell Therapy, in people with CD33 and/or FLT3 expressing blood cancers, including acute myeloid leukaemia and myelodysplastic syndromeA Phase 1, Multicenter, Open-Label Study of SENTI-202, a Selective Off-the-Shelf Logic Gated CAR NK Cell Therapy, in Subjects With CD33 and/or FLT3 Expressing Hematological Malignancies

Inclusion

• Subjects with CD33 and/or FLT3 expressing malignancies, including:

  • Relapsed refractory acute myeloid leukemia (AML) with morphologic relapse as defined by ≥5% bone marrow blasts who have received at least 1 prior line, but no more than 3 prior lines of standard anti-AML therapy. Subjects with FLT3-mutated or IDH ½-mutated disease must have received at least one prior targeted therapy.
  • Relapsed refractory myelodysplastic syndrome (MDS) with increased blasts who have received at least 1 prior line, but no more than 2 prior lines of anti-MDS therapy
  • Other hematological malignancies who have received at least 1 prior line of standard of care for the respective disease
  • Documentation of CD33 expression (or FLT3 expression if available) by individual institutional standard of care
• ECOG performance score of 0-1
• Adequate organ function including platelet count >20x109/L (platelet transfusion is permitted)
• Adequate recovery from toxicities from previous cancer treatments, as described in the study protocol
• Willing and able to provide written informed consent