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RecruitingLast updated: 23 September 2025

LOCUS: This is a study to monitor the long-term safety and tolerability of cell or gene therapy in people who have participated in prior AstraZeneca studiesA LOng-term Follow-up Master Protocol for Participants Who Received Cell or Gene Therapies in Other AstraZeneca StUdieS (LOCUS)

Trial purpose

Medical clipboardLong-term follow-up

Tumor type

Multi-Cancer Multi-Cancer

Age

People18 - 130

Trial acronym

LOCUS

Clinical summary

Summary

This is a multi-centre and multinational basket study that will monitor the long-term safety and tolerability of cell or gene therapies in participants that have taken part in other AstraZeneca cell or gene therapy studies for up to 15 years.

Conditions

This trial is treating people with prior participation in an AstraZeneca study where they received a cell or gene therapy

Eligibility

Inclusion

  1. The participant has received a cell or gene therapy in another AstraZeneca protocol.
  2. Provision of signed and dated, written informed consent before any study-specific proced

Exclusion

Not applicable

Inclusion

  • You have previously participated in a certain specific clinical trial.
  • You have had a certain type of treatment or surgical procedure.
Message

Clinical trials have complex eligibility criteria, and other criteria may apply for this trial. Ask your doctor about whether this trial could be right for you.

Participating hospitals

Recruiting hospitals

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More information

Trial Identifiers

Information on this page is partially produced from ClinicalTrials.gov *. View further details about this trial on the registry via the links below:

Trial sponsor

AstraZeneca

Scientific Title

A LOng-term Follow-up Master Protocol for Participants Who Received Cell or Gene Therapies in Other AstraZeneca StUdieS (LOCUS)

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