This study aims to learn about the safety and dosing of a new drug when given alone, or in combination with a drug called Zimberelimab, in people with advanced solid cancersA Phase 1 Study to Evaluate the Safety and Tolerability of GS-9911 as Monotherapy and in Combination With an Anti-PD-1 Monoclonal Antibody in Adults With Advanced Solid Tumors

Exclusion

• Positive serum pregnancy test or lactating female
• History of intolerance, hypersensitivity, or treatment discontinuation due to life- threatening immune-related adverse events on prior immunotherapy
• Receipt of the therapies listed below within the specified timeframe prior to planned Cycle 1 Day 1 including: major surgery (< 4 weeks), immunotherapy or biologic therapy (< 28 days), chemotherapy (< 21 days), targeted small molecule therapy (<14 days or 5 half-lives, whichever is sooner), hormonal or other adjunctive therapy (< 14 days), radiation therapy (< 21 days), live vaccine (< 28 days)
• Any prior allogeneic tissue/solid organ transplantation, including allogeneic stem cell transplantation
• Diagnosis of immunodeficiency, or requires systemic corticosteroids (> 10 mg of prednisone daily, or equivalent)
• History of autoimmune disease or active autoimmune disease that has required systemic treatment within 2 years prior to the start of study drug
• History of pneumonitis requiring treatment with corticosteroids, interstitial lung disease, drug-induced pneumonitis, or severe radiation pneumonitis (excluding localized radiation pneumonitis)
• Active second malignancy. Note: individuals with a history of malignancy that have been completed treated, with no evidence of active cancer for 2 years prior to enrollment, or individuals with surgically cured tumors with low risk of recurrence are allowed to enroll.
• Known active central nervous system (CNS) metastases and/or carcinomatous meningitis
• Symptomatic cardiovascular disease
• Active serious infection requiring ongoing treatment
• Active infection with hepatitis B virus (HBV), hepatitis C virus (HCV), or HIV.
• Symptomatic ascites or pleural effusion

Note: Other protocol defined Inclusion/Exclusion criteria may apply.