This study aims to see whether an experimental drug called disitamab vedotin works to treat different types of solid cancers that express HER2A Phase 2 Basket Study of Disitamab Vedotin in Adult Subjects With Previously Treated, Locally-Advanced Unresectable or Metastatic Solid Tumors That Express HER2

Inclusion

• Cohort 1: HNSCC

  • Pathologically-documented squamous cell carcinoma of the head and neck with primary tumor site arising from the oral cavity, oropharynx, hypopharynx, and larynx
  • Unresectable locally recurrent or metastatic stage disease

  • Prior therapies:

    • Participants must have disease progression after treatment with a platinum-based therapy
    • No more than 1 line of cytotoxic chemotherapy for advanced disease

• Cohort 2: NSCLC

  • Pathologically documented NSCLC
  • Unresectable locally-advanced or metastatic stage disease

  • Prior therapies

    • Must have progressed during or after a platinum-based therapy or, within 6 months of platinum-based adjuvant, neoadjuvant, or concomitant chemoradiotherapy for early or locally-advanced stage disease
    • Must have received prior anti-PD(L)1 therapy, unless contraindicated
    • No more than 2 prior lines of cytotoxic chemotherapy for advanced disease

• Cohort 3: Ovarian Cancer

  • Pathologically documented epithelial cancers of ovarian, fallopian tube, or peritoneal origin
  • Unresectable locally-advanced or metastatic stage disease

  • Prior therapies

    • Must have platinum resistant disease (6 months or less between the completion of platinum-based treatment and identification of recurrence)
    • Must not have received more than 4 lines of prior cytotoxic chemotherapies for advanced disease
    • May have received prior anti-PD(L)1 therapy

• Cohort 4: Endometrial Cancer

  • Must have pathologically documented adenocarcinoma of the endometrium
  • Must have unresectable locally-advanced or metastatic stage disease.

  • Prior therapies

    • Must have relapsed/progressed after at least one prior platinum-based chemotherapy for recurrent, metastatic or primary unresectable disease
    • Must not have received more than 3 lines of prior cytotoxic chemotherapies for advanced disease
    • May have received prior anti-PD(L)1 therapy
• HER2 expression of 1+, 2+, or 3+, as determined by local IHC testing on a fresh or archival tumor tissue
• Measurable disease per RECIST v1.1 criteria as assessed by the investigator
• Able to provide formalin-fixed, paraffin-embedded (FFPE) tumor tissue blocks (or freshly sectioned slides)
• Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1