Trial purpose
Cancer treatment
Tumor type
Haematological
Age
18+
Clinical summary
Summary
B-cell malignancies are a group of cancers of B lymphocytes, a type of white blood cell responsible for fighting infections.
The purpose of this study is to assess an investigational drug called ABBV-525 as a monotherapy. ABBV-525 is a targeted therapy that inhibits MALT1 and is administered as an oral tablet.
The study has three parts:
- Part 1 (dose escalation): participants will receive escalating oral doses of ABBV-525.
- Part 2 (dose optimisation): participants will receive one of two oral doses of ABBV-525, until the recommended phase 2 dose (RP2D) is determined.
- Part 3 (dose expansion): participants will receive the RP2D oral dose of ABBV-525.
The estimated duration of the study is up to 64 months. Approximately 100 adult participants will be enrolled in the study across sites worldwide. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic and may require frequent medical assessments, blood tests, and scans.
Conditions
This trial is treating people with B-cell malignancies
Eligibility
Inclusion
- Dose Escalation (Part 1) Only: Participants with a documented diagnosis of one of the following third line or later of treatment (3L)+ mature B-cell malignancies, from the World Health Organization (WHO)-defined histologies as defined in the protocol.
- Dose Optimization (Part 2) Only: Participants with documented diagnosis of chronic lymphocytic leukemia (CLL) who are 3L+, +/- cysteine-to-serine point mutation at residue 481 of BTK-domain active site (C481S with histology based on WHO criteria, with measurable disease requiring treatment as defined by the International Workshop on Chronic Lymphocytic Leukemia (iwCLL).
- Dose Expansion (Part 3) Only: Participants with documented diagnosis of non-germinal center B cell (GCB) Diffuse large B-cell lymphoma (DLBCL) who are 3L+ chimeric antigen receptor T-cells (CAR-T)/Hematopoietic cell transplant (HCT) relapsed/refractory (R/R) and/or ineligible with histology based on WHO criteria, with measurable disease requiring treatment.
- Participant has an Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0 or 1.
- Participant has a life expectancy \>= 12 weeks.
- Adequate hematological and hepatic function as defined in the protocol.
- Must have archival or freshly collected tumor tissue for correlative studies before study enrollment.
- Participants with prior central nervous system (CNS) disease that has been effectively treated may be eligible.
- Participants with resolved coronavirus disease 2019 (COVID-19) infection are eligible.
Exclusion
- Known active CNS disease, or primary CNS lymphoma.
- Known bleeding disorders.
- Known history of stroke or intracranial hemorrhage within 12 months prior to first dose of study treatment.
- Uncontrolled active systemic infection, or active cytomegalovirus infection.
- Active hepatitis B or C infection.
- Known history of human immunodeficiency virus (HIV).
- Known active COVID-19 infection. Participant must not have signs/symptoms associated with COVID-19 infection or known exposure to a confirmed case of COVID-19 infection during screening. If participant has signs/symptoms suggestive of COVID-19 infection, the participant must have a negative molecular (eg, polymerase chain reaction) test or 3 negative antigen test results at least 24 hours apart.
Inclusion
- You have had treatment, but your cancer has come back (relapsed or recurrent).
- You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
- You are able to swallow medication by mouth.
Exclusion
- You have certain types of non-cancer medical conditions.
Clinical trials have complex eligibility criteria, and other criteria may apply for this trial. Ask your doctor about whether this trial could be right for you.
More information
Trial Identifiers
Information on this page is partially produced from ClinicalTrials.gov *. View further details about this trial on the registry via the links below:
Trial sponsor
AbbVie
Scientific Title
A First-in-Human Study of ABBV-525 (MALT1 Inhibitor) in B-Cell Malignancies
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