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RecruitingLast updated: 13 February 2026

ZERO2: A screening study that aims to improve outcomes for children and young people with cancer by using detailed molecular and genomic analysis of their tumours to guide treatment decisionsPrecision Medicine for Every Child With Cancer

Trial purpose

Medical clipboardDiagnostic

Tumor type

Multi-Cancer Multi-Cancer

Age

People<25

Trial acronym

ZERO2

Clinical summary

Summary

Through the pilot TARGET and national PRISM trials, the feasibility and benefits of using comprehensive molecular profiling and preclinical drug testing in real time for high-risk (HR) patients has been demonstrated.

However, the role of precision medicine, especially in facilitating diagnosis and risk stratification in non-HR childhood cancers has not been studies.

Integrative tumour-germline whole genome sequencing (WGS) analysis has the potential to advance our understanding of cancer predisposition.

In this study, the ZERO platform will be extended to all children with cancer in Australia and New Zealand, evaluating the benefits of precision medicine in different childhood cancer types and risk groups.

This is a screening study.

Conditions

This trial is treating people with paediatric cancer

Eligibility

Inclusion

  1. Age < 18 years Note: Individual patients aged 19 - 25 years old with a pediatric cancer, e.g., neuroblastoma, may be enrolled after discussion with, and at the discretion of, the Study Chair or their delegate.
  2. Life expectancy >6 weeks at time of enrolment
  3. Consent i. Signed and dated informed consent for study enrolment from participant aged ≥ 18 years or from parent/guardian of participant aged <18 years. ii. Separate signed and dated informed consent for understanding the role of germline testing and choice for the return of germline results.
Message

Clinical trials have complex eligibility criteria, and other criteria may apply for this trial. Ask your doctor about whether this trial could be right for you.

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Recruiting hospitals

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More information

Trial Identifiers

Information on this page is partially produced from ClinicalTrials.gov *. View further details about this trial on the registry via the links below:

Trial sponsor

Australian & New Zealand Children's Haematology/Oncology Group

Scientific Title

Precision Medicine for Every Child With Cancer

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