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RecruitingLast updated: 28 March 2024

PRAME: This study is evaluating how safe and effective a new type of immunotherapy is in people with advanced or metastatic solid cancers that are PRAME positivePhase 1/2 Study of IMC-F106C in Advance PRAME-Positive Cancers

Clinical summary


This study is evaluating IMC-F106C, an immune-mobilising monoclonal T cell receptor against cancer that is designed for the treatment of cancers positive for the tumour-associated antigen PRAME. The study will be conducted in two phases:

Phase 1: Aims to identify the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) of IMC-F106C as a single agent and administered in combination with a checkpoint inhibitor, chemotherapy, or another ImmTAC molecule.

Phase 2: Aims to assess the efficacy of IMC-F106C as a single agent in selected advanced solid cancers.



This trial is treating patients with advanced solid cancers that are HLA-A*02:01 and PRAME positive


Multi-Cancer Multi-Cancer





Trial Acronym


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Trial Identifiers

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Trial sponsor

Immunocore Ltd

Scientific Title

Phase 1/2 Study of IMC-F106C in Advance PRAME-Positive Cancers



  1. ECOG PS 0 or 1
  2. HLA-A*02:01 positive
  3. PRAME positive tumor
  4. Relapsed from, refractory to, or intolerant of standard therapy
  5. If applicable, must agree to use highly effective contraception
  6. Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the Informed Consent (ICF) and protocol


  1. Symptomatic or untreated central nervous system metastasis
  2. Recent bowel obstruction
  3. Ascites requiring recurrent paracentesis
  4. Significant immune-mediated adverse event with prior immunotherapy (patients in checkpoint inhibitor combination treatment)
  5. Inadequate washout from prior anticancer therapy
  6. Significant ongoing toxicity from prior anticancer treatment
  7. Out-of-range laboratory values
  8. Clinically significant lung, heart, or autoimmune disease
  9. Ongoing requirement for immunosuppressive treatment
  10. Prior solid organ or bone marrow transplant
  11. Active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection
  12. Known history of human immunodeficiency virus (HIV)
  13. Significant secondary malignancy
  14. Hypersensitivity to study drug or excipients
  15. Antibiotics, vaccines or surgery within 2-4 weeks prior to the first dose of study intervention
  16. Pregnant or lactating
  17. Any other contraindication for applicable combination partner based on local prescribing information


  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
  • You have had treatment, but your cancer has come back.
  • Your cancer has not spread to other parts of the body.
  • Your cancer has spread to other parts of the body.


  • You have been diagnosed with a prior or secondary type of cancer.
  • You have certain types of non-cancer medical conditions.
  • You have had certain treatments, surgical procedures or drugs.

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

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