Trial purpose
Cancer treatment
Tumor type
Haematological
Age
18+
Clinical summary
Summary
Patients will be randomised into one of three treatment Arms. In the first Arm, patients will receive oral Acalabrutinib in combination with Venetoclax. In the second Arm, patients will receive oral Acalabrutinib in combination with Venetoclax with or without the immunotherpy drug, Obinutuzumab. In the final treatment Arm, patients will receive the investigators choice of chemoimmunotherapy, containing Fludarabine, Cyclophosphamide and Rituximab (FCR).
Conditions
This trial is treating people with chronic lymphocytic leukaemia (CLL)
Eligibility
Inclusion
- Men and women ≥18 years of age.
- Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.
- Diagnosis of CLL that meets published diagnostic criteria (Hallek et al. 2018)
- Active disease per IWCLL 2018 criteria that requires treatment.
- Participants must use highly effective birth control throughout the study.
Exclusion
- Any prior CLL-specific therapies.
- Detected del(17p) or TP53 mutation.
- Transformation of CLL to aggressive non-Hodgkin lymphoma (NHL) (e.g., Richter's transformation, prolymphocytic leukemia [PLL], or diffuse large B cell lymphoma [DLBCL]), or central nervous system (CNS) involvement by leukemia.
- History of confirmed progressive multifocal leukoencephalopathy (PML).
- Received any investigational drug within 30 days before first dose of study drug.
- Major surgical procedure within 30 days before the first dose of study drug.
- Significant cardiovascular disease such as symptomatic arrhythmias, congestive heart failure, or myocardial infarction within 6 months of Screening, or any Class 3 or 4 cardiac disease. Note: Subjects with controlled, asymptomatic atrial fibrillation are allowed to enroll on study.
- Malabsorption syndrome, disease significantly affecting gastrointestinal function, or resection of the stomach, or extensive small bowel resection that is likely to affect absorption, symptomatic inflammatory bowel disease, or partial or complete bowel obstruction, or gastric restrictions and bariatric surgery, such as gastric bypass.
- Received a live virus vaccination within 28 days of first dose of study drug.
- Known history of infection with human immunodeficiency virus (HIV).
- Serologic status reflecting active hepatitis B or C infection.
- History of known hypersensitivity or anaphylactic reactions to study drugs or excipients.
- History of stroke or intracranial hemorrhage within 6 months before first dose of study drug.
- Known bleeding disorders.
- Requires or receiving anticoagulation with warfarin or equivalent vitamin K antagonists.
- Female participants must not be breastfeeding or pregnant.
- Concurrent participation in another therapeutic clinical trial.
Inclusion
- You have been diagnosed with cancer, but have not received any treatment.
Exclusion
- You have certain types of non-cancer medical conditions.
- You have had certain treatments, surgical procedures or drugs.
- You are currently being treated on a clinical trial.
Clinical trials have complex eligibility criteria, and other criteria may apply for this trial. Ask your doctor about whether this trial could be right for you.
More information
Trial Identifiers
Information on this page is partially produced from ClinicalTrials.gov *. View further details about this trial on the registry via the links below:
Trial sponsor
Acerta Pharma BV
Scientific Title
A Randomized, Multicenter, Open-Label, Phase 3 Study to Compare the Efficacy and Safety of Acalabrutinib (ACP-196) in Combination With Venetoclax With and Without Obinutuzumab Compared to Investigator's Choice of Chemoimmunotherapy in Subjects With Previously Untreated Chronic Lymphocytic Leukemia Without Del(17p) or TP53 Mutation
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