Trial purpose
Cancer treatment
Tumor type
Lung cancer
Age
18+
Clinical summary
Summary
This trial is using ventilation and perfusion positron emission computed tomography (V/Q PET/CT) scans to adapt radiotherapy plans using Volumetric Modulated Arc Therapy (VMAT) to avoid regions of functional lung and deliver a higher dose to the primary tumour.
Conditions
This trial is treating people with non-small cell lung cancer
Eligibility
Inclusion
- Age ≥ 18 years;
- Written informed consent has been provided.
- Histologically or cytologically confirmed Non-Small Cell Lung Cancer
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2 within 2 weeks prior to registration
- Locally advanced disease (stage IIIA, IIIB, IIIC as per American Joint Committee on Cancer AJCC, 8th ed.) as confirmed on staging 18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose (FDG) PET/CT
- No evidence of metastatic intracranial disease on CT brain with contrast or MRI
- Willing to participate in the full follow up schedule
- Planned for treatment with curative intent
Exclusion
- Participant is not able to tolerate supine position on PET/CT bed for the duration of the PET/CT acquisitions, is not cooperative, or needs continuous nursing (e.g. patient from Intensive Care Unit) or is unable to attend full course of follow up visits
- Pregnancy or Breast-feeding
- If history of a prior extra thoracic invasive malignancy (except non-melanomatous skin cancer) must be free from recurrence for a minimum of 3 years at the time of registration
- Prior radiotherapy to the lungs or mediastinum (a history of prior breast radiotherapy is not an exclusion)
- Prior known history of interstitial lung disease * A history of renal impairment or reaction to iodine contrast is not an exclusion criteria, if a patient has medical comorbidities that exclude the use of iodine contrasts, these exploratory investigations can be omitted.
Exclusion
- You have certain types of non-cancer medical conditions.
- You have had certain treatments, surgical procedures or drugs.
Clinical trials have complex eligibility criteria, and other criteria may apply for this trial. Ask your doctor about whether this trial could be right for you.
More information
Trial Identifiers
Information on this page is partially produced from ClinicalTrials.gov *. View further details about this trial on the registry via the links below:
Trial sponsor
Peter MacCallum Cancer Centre
Scientific Title
High Intensity Functional Image Guided Vmat Lung Evasion
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