Trial purpose
Cancer treatment
Tumor type
Gynaecological
Age
21 - 99
Clinical summary
Summary
The purpose of this trial is to determine if targeting platinum resistant or refractory C5 high-grade serous, high grade endometrioid or undifferentiated ovarian, primary peritoneal and Fallopian tube with vinorelbine can improve patient outcomes. Patients will receive Vinorelbine 25 mg/m2 intravenously on day-1 and day-8 of a 3 week cycle. Drug administration will commence following confirmation of eligibility into the study for a maximum of 12 months, until disease progression, intolerable toxicity or withdrawal of patient consent (whichever event occurs first).
Conditions
This trial is treating people with C5 high-grade serous, endometrioid or undifferentiated ovarian, primary peritoneal or fallopian tube cancer
Eligibility
Inclusion
- Provided written informed consent
- Patients must have platinum resistant or refractory HGSOC; defined as progressive disease by imaging ≤ 6 months from last date of most recent platinum-based therapy or rising CA-125 based on GCIG criteria
- Have histological confirmation of high-grade serous or high-grade endometrioid or undifferentiated tumour of the primary peritoneum, fallopian tube cancer or ovary
- Molecular subtyping by Nanostring technology must confirm C5 subtype on primary ovarian surgical sample or a biopsy of recurrent disease
- Patients must not have received more than 3 prior chemotherapy regimens, which may include chemotherapy, biologics or other targeted therapies (this does not include maintenance treatment or hormonal therapy) for platinum resistant disease
- Measurable disease by RECIST criteria (version 1.1).
- At time of registration, if the patient has had previous treatment it must have been at least 28 days since major surgery or radiation therapy; 28 days from any other previous anti-cancer therapy including biologics; 14 days since hormone therapy. Patients must have recovered to ≤ grade 1 from their treatment-related events with the exception of alopecia.
- Age ≥ 18 years of age (Age ≥ 21 years of age for Singapore sites)
-
Have clinically acceptable laboratory screening results within certain limits specified below:
- AST and ALT ≤ 2.5 times upper limit of normal (ULN)
- Total bilirubin ≤ ULN
- Creatinine ≤ 1.5 x UL
- Absolute neutrophil count ≥ 1500 cells/mm
- Platelets ≥ 100,000/mm3
- Hemoglobin ≥ 9.0 g/dl
- Have an ECOG performance status of ≤ 2.
- Women of child-producing potential must agree to use effective contraceptive methods prior to study entry, during study participation, and for at least 30 days after the last administration of study medication.
- Have the ability to understand the requirements of the study, provide written informed consent, abide by the study restrictions, and agree to return for the required assessments.
- Able to tolerate IV medication.
- Life expectancy greater than 6 months
Exclusion
- Women who are pregnant or nursing
- Previous exposure to vinorelbine
- Patients known to be hypersensitive to vinorelbine or any vinca alkaloids previously
- Persistent toxicities (≥ Common Terminology Criteria for Adverse Event (CTCAE) v4.0 grade 1) caused by previous cancer therapy, excluding alopecia
- Have active, acute, or chronic clinically significant infections or bleeding.
- Have active angina pectoris, stroke, myocardial infarction, or any other pre-existing uncontrolled cardiovascular condition within the last 6 months.
- Have additional uncontrolled serious medical or psychiatric illness.
- Require therapeutic doses of anti-coagulation with warfarin or warfarin derivatives. However, treatment with low molecular weight heparin (LMWH) is allowed.
- Known symptomatic CNS metastases. Treated brain metastatis that are stable for more than ≥4 weeks are allowed.
- Psychiatric disorders that would hinder compliance with study protocol
- History of other malignancies within the past 5 years except for curatively treated skin BCC or SCC or cervical carcinoma in situ. Patients who have had curatively treated breast cancer, with completion of adjuvant chemotherapy more than three years before are allowed.
- Require treatment with drugs known to be potent inducers or inhibitors of CYP3A4 at the time of registration
- Subjects known to be HIV positive or with active and untreated Hepatitis B or Hepatitis C infection. Patients with controlled Hepatitis B or Hepatitis C infection on treatment with antiviral medication are allowed.
Inclusion
- You have had treatment, but your cancer has come back (relapsed or recurrent).
Exclusion
- You have been diagnosed with a prior or secondary type of cancer.
- You have certain types of non-cancer medical conditions.
- You have had certain treatments, surgical procedures or drugs.
Clinical trials have complex eligibility criteria, and other criteria may apply for this trial. Ask your doctor about whether this trial could be right for you.
More information
Trial Identifiers
Information on this page is partially produced from ClinicalTrials.gov *. View further details about this trial on the registry via the links below:
Trial sponsor
National University Hospital, Singapore
Scientific Title
Phase II Study of Intravenous Vinorelbine in Patients With Relapsed Platinum Resistant or Refractory C5 High Grade Serous, Endometrioid, or Undifferentiated Primary Peritoneum, Fallopian Tube or Ovarian Cancer
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