TACTI-mel: This phase I trial is trying to determine the recommended dose of a new drug (IMP321) when given in combination with an immunotherapy agent (pembrolizumab) for people with metastatic melanomaA Multicentre, Open Label, Dose Escalation, Phase 1 Study in Patients With Unresectable or Metastatic Melanoma Receiving IMP321 (LAG-3Ig Fusion Protein) as an Adjunctive Therapy to Anti-PD-1 Therapy With Pembrolizumab

Exclusion

• More than four prior lines of therapies for advanced or metastatic disease.
• Prior PD-1/PDL-1 targeted therapy
• Currently receiving treatment with another investigational drug, or less than 4 weeks since ending treatment on another investigational drug
• Currently receiving systemic chemotherapy, targeted small molecule therapy, radiotherapy, or biological cancer therapy (other than pembrolizumab) or less than 4 weeks since completion of these therapies and first dose of study treatment
• History of irAEs from ipilimumab of CTCAE Grade 4 requiring steroid treatment
• Known cerebral or leptomeningeal metastases
• Serious intercurrent infection within 4 weeks prior to first dose of study treatment
• Active acute or chronic infection
• History or evidence of interstitial lung disease or active non-infectious pneumonitis
• Active auto-immune disease requiring immunosuppressive therapy
• HIV positivity, active hepatitis B or hepatitis C
• Continuous systemic treatment with either corticosteroids or other immunosuppressive medications within 4 weeks prior to first dose of study treatment