RANGE: This phase III trial is evaluating the safety and efficacy of the study drug ramucirumab in combination with docetaxel in participants with urothelial cancer who have failed prior platinum based therapy.A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Ramucirumab Plus Docetaxel Versus Placebo Plus Docetaxel in Patients With Locally Advanced or Unresectable or Metastatic Urothelial Carcinoma Who Progressed on or After Platinum-Based Therapy

Exclusion

• Have received more than one prior systemic chemotherapy regimen for metastatic disease.
• Have received prior systemic taxane therapy for transitional cell carcinoma (TCC) of the bladder, urethra, ureter, or renal pelvis in any setting (neoadjuvant, adjuvant, metastatic).
• Have received more than one prior antiangiogenic agent (that is, bevacizumab, sorafenib, sunitinib) for TCC of the urothelium.
• Have received radiation therapy within 4 weeks (≤4 weeks) prior to randomization or has not recovered from toxic effects of the treatment that was given >4 weeks prior to randomization.
• Have a history of uncontrolled hereditary or acquired bleeding or thrombotic disorders.
• Have experienced a Grade ≥3 bleeding event within 3 months (≤3 months) prior to randomization.
• Have uncontrolled intercurrent illness, including, but not limited to symptomatic anemia, uncontrolled hypertension, symptomatic congestive heart failure, unstable angina pectoris, symptomatic or poorly controlled cardiac arrhythmia, psychiatric illness, or any other serious uncontrolled medical disorders.
• Have experienced any arterial or venothrombotic or thromboembolic events, including, but not limited to myocardial infarction, transient ischemic attack, or cerebrovascular accident, within 6 months (≤6 months) prior to randomization.
• Have known untreated brain metastases, uncontrolled spinal cord compression, or leptomeningeal disease.
• Have human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome-related illness.
• Have undergone major surgery within 28 days (≤28 days) prior to randomization or subcutaneous venous access device placement within 7 days (≤7 days) prior to randomization.
• The participant is pregnant prior to randomization or lactating.
• Have a concurrent malignancy or had another malignancy within 5 years (≤5 years) of study enrollment.