BeiGene 2: This phase I trial is evaluating a new drug known as BGB-290 in patients with solid cancersA Phase IA, Open Label, Multiple Dose, Dose Escalation Study to Investigate the Safety and Pharmacokinetics of the PARP Inhibitor BGB-290 in Subjects With Solid Tumors

Exclusion

1. Participants did not receive prior therapies targeting poly-ADP ribose polymerase (PARP).
2. Participants who are not considered to be refractory to platinum-based therapy (e.g., progressive disease at the first tumor assessment while receiving platinum treatment).
3. Participants who have not been treated with chemotherapy, biologic therapy, immunotherapy, or other investigational agent within five times half-lives of the last treatment or within 4 weeks (whichever is longer) prior to starting study drug (or who have not recovered from the side effects of such therapy).
4. Participants who have not undergone major surgery/surgical therapy for any cause within 4 weeks of screening visit.
5. Participants must have recovered from the treatment and have a stable clinical condition before entering this study.
6. Participants who have not received therapeutic radiotherapy to target lesions. 7.Participants who have received local palliative radiotherapy of non-target lesions for local symptom control within the last 21 days must have recovered from any adverse effects of radiotherapy before recording screening symptoms. 8.No untreated brain metastasis or unstable neurologic condition after the completion of radiation, or requiring corticosteroid of > 40 mg prednisone daily equivalent dose to control the symptoms.

NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.