Optimise viewing for

Toggle between patient and health professional views. The patient version is simplified to help people easily find suitable trials, while the professional view provides full detail.

Health ProfessionalsPatients

RecruitingLast updated: 27 May 2025

PABR: This study will assess how safe and effective a new way of delivering radiation therapy, called Partially Ablative Body Radiotherapy (PABR) to tumours that are considered too bulky to treat with curative intentA Prospective Single-Arm Pilot Study of the Safety, Tolerability and Preliminary Efficacy of Partially Ablative Body Radiotherapy (PABR) for the Palliation of Bulky Tumours

Trial purpose

Medical clipboardCancer treatment

Tumor type

Multi-Cancer Multi-Cancer

Age

People18+

Trial acronym

PABR

Clinical summary

Summary

Eligible participants will undergo 5 sessions of radiation therapy on non-consecutive days over 2 weeks. The radiation therapy will be planned to deliver a higher dose to the core of the tumour and a lower, palliative dose to the periphery. 

Participants will have data collected on treatment related adverse events and tumour response to the radiation therapy, and will be asked to complete questionnaires on outcomes such as pain and quality of life.

It is hoped that findings from this study will help develop PABR as a treatment modality for the palliation of bulky tumours.

Conditions

This trial is treating people with solid cancers that are not suitable to other curative treatment, but are candidates for palliative radiation therapy for a tumour size of at least 5cm

Eligibility

Inclusion

Histologically or cytologically confirmed non-haematologic malignancy not amenable to curative intent treatment.
Must be a candidate for palliative radiotherapy for a tumour size of at least 5cm as measured by clinical examination or radiologic imaging
At least one measurable disease tumour lesion as assessed by investigator per RECIST v1.1
Not suitable for SABR (stereotactic ablative body radiotherapy) or surgery, or has declined surgery

Exclusion

Tumours at or within 2cm from spinal cord
Prior radiotherapy that overlaps with planned site of intervention within 2 years prior to screening
Received concurrent cytotoxic or targeted therapy within 3-4 weeks prior to the fraction of PABR, or concurrent use of these therapies during intervention period
Evidence of central necrosis on imaging

Inclusion

  • Your cancer has spread to other parts of the body (metastatic) or has grown into nearby parts of the body (locally advanced).
  • Your cancer has not spread to other parts of the body (localised).
  • You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.

Exclusion

  • You have certain types of non-cancer medical conditions.
  • You have had certain treatments, surgical procedures or drugs.
Message

Clinical trials have complex eligibility criteria, and other criteria may apply for this trial. Ask your doctor about whether this trial could be right for you.

Participating hospitals

Recruiting hospitals

InformationTell us if you find this trial availability is not accurate.Report inaccuracy

More information

Trial Identifiers

Information on this page is partially produced from ANZCTR *. View further details about this trial on the registry via the links below:

Trial sponsor

Peter MacCallum Cancer Centre

Scientific Title

A Prospective Single-Arm Pilot Study of the Safety, Tolerability and Preliminary Efficacy of Partially Ablative Body Radiotherapy (PABR) for the Palliation of Bulky Tumours

Get Support

Peer Connect

You might find it helpful to speak to someone who has 'been there before'. Our Peer Connect program can provide one-on-one phone support from someone who understands what you're going through and has clinical trials experience.

Know more about Peer Connect

Contact cancer support

If you need cancer information and practical support for yourself, a carer, family or friend, contact Cancer Council to speak with an experienced health professional on 13 11 20.

Get support

Multilingual information

Learn more about clinical trials through this collection of resources in languages other than English.

View information

CloseReport inaccuracy

Thank you for helping us to increase accuracy of the trial. Our team will validate the information and update the information as soon as possible.

HelpThis verification step helps prevent fraudulent transactions from automated software.
Submitting ... Please wait