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RecruitingLast updated: 7 July 2026

SUPER-ED: Testing a new, more coordinated way of caring for people with cancer of unknown primary, to see if it leads to faster diagnosis and better support compared to current treatment approachesSolving Unknown Primary cancER Earlier Diagnosis (SUPER-ED): A stepped wedge cluster randomised controlled trial implementing a Model of Care to support earlier diagnosis

Trial purpose

Medical clipboardDiagnostic; Side effect and wellbeing

Tumor type

Cancer of Unknown Primary Cancer of Unknown Primary

Age

People18+

Trial acronym

SUPER-ED

Clinical summary

Summary

Cancer of unknown primary (CUP) is when cancer has spread in the body, but doctors cannot find where it first started.

This study is looking at a new, more standardised way of caring for people with CUP. The aim is to see whether this approach can help doctors diagnose the cancer sooner and improve patient care.

Who can take part?
You may be eligible for this study if you:

  • are aged 18 years or older
  • have been diagnosed with a malignancy (cancer) of undefined primary origin (CUP)
  • are able to have further tests, as agreed by your doctor

Study details
If you choose to join the study, you will receive one of two types of care:

New model of care
This is a more structured and coordinated approach, which may include:

  • a set of standard tests to help find where the cancer started
  • review of your case by a specialised team of cancer experts (called a multidisciplinary meeting)
  • support from a dedicated CUP care coordinator at your local health service
  • access to an online information and education website for patients and doctors

Usual care (standard treatment pathway)
This is the care currently provided in most hospitals and also includes support to patients, however this is less personalised than the proposed new model of care. It may include:

  • support from your treating team
  • written information about CUP (such as a Cancer Council booklet)
  • Access to the Cancer Council helpline

Which type of care you receive depends on when you join the study and which approach your hospital is using.

 

 

It is hoped this research will demonstrate that provision of a new standardised model of care is feasible and that implementation of the new model of care may lead to faster diagnosis times and consequently better provision of care to patients with CUP. 

Learn more about this study on the Peter Mac website.

Conditions

This trial is treating people with a malignancy of undefined primary origin (cancer of unknown primary location)

Eligibility

Inclusion

- 18 years of age or older
- Presenting with malignancy of undefined primary origin, i.e. suspicion of metastatic malignancy without an obvious primary site on imaging
- Clinically appropriate to undergo diagnostic work-up, as determined by the treating clinician
-Able to provide written or verbal consent. For participants with limited English proficiency a legally acceptable representative may be a witness such as a qualified interpreter.

Exclusion

-Unable to provide (written or verbal) consent.

Inclusion

  • You have the type of cancer, symptoms, or health risks that this clinical trial is focused on.
Message

Clinical trials have complex eligibility criteria, and other criteria may apply for this trial. Ask your doctor about whether this trial could be right for you.

Participating hospitals

Recruiting hospitals

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More information

Trial Identifiers

Information on this page is partially produced from ANZCTR *. View further details about this trial on the registry via the links below:

Trial sponsor

Peter MacCallum Cancer Centre

Scientific Title

Solving Unknown Primary cancER Earlier Diagnosis (SUPER-ED): A stepped wedge cluster randomised controlled trial implementing a Model of Care to support earlier diagnosis

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