Trial purpose
Cancer treatment
Tumor type
Breast
Age
18+
Clinical summary
Summary
The duration of this trial is expected to be 3 months for each participant. Radiotherapy treatment will commence at least 4-weeks after completion of standard chemotherapy and will be delivered 5-days a week, over 5-weeks. Approximately 4-8 weeks following successful completion of radiotherapy, the participant will have a surgery to remove the breast and immediate breast reconstruction.
Conditions
This trial is treating people with breast cancer
Eligibility
Inclusion
Patient has provided written informed consent for the trial
Female patients greater than or equal 18 years of age on day of signing informed consent
Patient has histologically confirmed invasive, Grade 1, 2 or 3 breast carcinoma
Primary tumour is T2, T3 or T4 and N1+
Patient is a candidate for radiotherapy in the prone position and mastectomy with immediate autologous reconstruction as assessed by the breast surgeon, the plastic surgeon and the radiation oncologist
Patient has received neoadjuvant systemic therapy, including chemotherapy and/or targeted therapies
Patient ECOG Performance status of 0 or 1
Patient is willing and able to comply with the protocol requirements for the duration of the study including undergoing radiotherapy, surgery, scheduled visits and follow up
Exclusion
Inflammatory breast cancers with documented skin involvement
Presence of ductal carcinoma in situ (DCIS) alone
Pregnant or lactating patients
Contraindication to radiotherapy e.g. scleroderma
Prior radiotherapy which precludes giving radiotherapy with curative intent to breast and locoregional nodes
Inclusion
- You have had a certain type of treatment or surgical procedure.
Exclusion
- You have certain types of non-cancer medical conditions.
- You have had certain treatments, surgical procedures or drugs.
Clinical trials have complex eligibility criteria, and other criteria may apply for this trial. Ask your doctor about whether this trial could be right for you.
More information
Trial Identifiers
Information on this page is partially produced from ANZCTR *. View further details about this trial on the registry via the links below:
Trial sponsor
Victorian Comprehensive Cancer Centre & Peter MacCallum Cancer Centre
Scientific Title
A Pilot Study of Prone Position Neoadjuvant Breast Radiotherapy to Reduce Skin Toxicity
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