Trial purpose
Cancer treatment
Tumor type
Haematological
Age
18+
Trial acronym
BLOCK PCNSL (NHL32)
Clinical summary
Summary
All participants in this trial will receive chemotherapy induction therapy (CIT) of either A) Rituximab, Methotrexate, Procarbazine & Vincristine (R-MPV) Cytarabine (Ara-C); or B) Cytarabine, Thiopeta & Rituximab (MATRix). The CIT given is at the discretion of the participant's clinician and is not assessed as part of this study. Once the induction treatment is complete, participants will receive Pembrolizumab immunotherapy (200mg via intravenous infusion) commencing 4-6 weeks after last CIT exposure, and administered every 3 weeks for 35 cycles/2 years.
Conditions
This trial is treating people with primary central nervous system lymphoma
Eligibility
Inclusion
Treatment-naïve new diagnosis of PCNSL (DLBCL)
Age = greater than or equal to 18 years
ECOG = less than or equal to 3
Considered appropriate for induction CIT as per investigator
No standard contraindication to immune checkpoint inhibition
Exclusion
Active autoimmune disease
Unfit for induction CIT (prohibitive organ dysfunction)
Non-B-cell lymphoma subtype
Systemic involvement with aggressive lymphoma
Inclusion
- You have been diagnosed with cancer, but have not received any treatment.
Exclusion
- You have certain types of non-cancer medical conditions.
Clinical trials have complex eligibility criteria, and other criteria may apply for this trial. Ask your doctor about whether this trial could be right for you.
More information
Trial Identifiers
Information on this page is partially produced from ANZCTR *. View further details about this trial on the registry via the links below:
Trial sponsor
Merck,Australasian Leukaemia and Lymphoma Group (ALLG)
Scientific Title
An ALLG Phase II study of pembrolizumab checkpoint blockade following chemoimmunotherapy for primary central nervous system lymphoma
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