Trial purpose
Cancer treatment
Tumor type
Upper gastrointestinal tract
Age
18 - 85
Clinical summary
Summary
Eligible participants will receive liver radiation therapy called Stereotactic Ablative Body Radiotherapy (SABR). Kilovoltage Intrafraction Monitoring (KIM) tracking will be tested during mock treatment. If it is found to be successful, it will be used throughout treatment. If it is found to be unsuccessful, cone beam CT imaging will be used instead.
Conditions
This trial is treating people with liver cancer
Eligibility
Inclusion
- ECOG performance status 0-1
- Life expectancy >6 months
- Number of lesions: ≤ 3
- Lesion size : < 10 cm for a single lesion (and up to 10 cm cumulative diameter for multiple lesions)
- Child-Pugh A or B7 within 6 weeks prior to study entry
- Unsuitable for RFA or resection or transplant
- Distance from GTV to luminal structures (i.e., oesophagus, stomach, duodenum, small or large bowel) ≥ 10mm
- All blood work obtained within 6 weeks prior to study entry with adequate organ function
- May have had previous surgery, RFA or ethanol injection
- Patient must have been discussed at multidisciplinary tumour board with consensus opinion for SBRT
Exclusion
- HCC/cholangiocarcinoma with evidence of metastatic disease including nodal or distant metastases
- Metastatic disease with complete liver disease response to first-line chemotherapy (i.e. no target for SBRT)
- Previous radiation to the liver (including SIRTEX)
- Untreated HIV or active hepatitis B/C
- On systemic antineoplastic drug therapy within 7 days before inclusion
- Pregnant or lactating women
Inclusion
- Your cancer has not spread to other parts of the body (localised).
- You have been diagnosed with cancer, but have not received any treatment.
- You have had treatment but your cancer has gotten worse or has not responded to the treatment you have been given.
- You are currently receiving treatment for your cancer.
Exclusion
- You have certain types of non-cancer medical conditions.
- You have had certain treatments, surgical procedures or drugs.
Clinical trials have complex eligibility criteria, and other criteria may apply for this trial. Ask your doctor about whether this trial could be right for you.
More information
Trial Identifiers
Information on this page is partially produced from ClinicalTrials.gov *. View further details about this trial on the registry via the links below:
Trial sponsor
University of Sydney
Scientific Title
Liver Ablative Radiotherapy Utilising Kilovoltage Intrafraction Monitoring (KIM)
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