Summary
This study is recruiting people with chronic lymphocytic leukaemia who have had prior treatment with venetoclax targeted therapy in combination with an anti-CD20 antibody, with or without another therapy.
Eligible participants must have achieved a document response to their first-line therapy treatment to be eligible. Participants will be assigned to one of two experimental cohorts.
Participants in both cohorts will receive combination targeted therapy that consists of intravenous (IV) obinutuzumab plus oral venetoclax (VenG). This will be given in 28-day cycles for a total of 6 cycles per cohort.
Following this, all participants will receive venetoclax alone. Those in Cohort 1 will receive 6 cycles of venetoclax alone. Those in Cohort 2 will receive 18 cycles of venetoclax alone.