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Closed (no longer recruiting)Last updated:26 November 2022

SKYSCRAPER-01: This phase III trial is trying to understand how safe and effective it is to combine two types of immunotherapy to treat patients with non-small cell lung cancer that has spread to other parts of the bodyA Phase III, Randomized, Double-Blinded, Placebo-Controlled Study of Tiragolumab, an Anti-Tigit Antibody, in Combination With Atezolizumab Compared With Placebo in Combination With Atezolizumab in Patients With Previously Untreated Locally Advanced Unresectable or Metastatic PD-L1-Selected Non-Small Cell Lung Cancer

Clinical summary Eligibilty Participating hospital Support

Clinical summary

Summary

Eligible patients will be randomised to receive Atezolizumab followed by Tiragolumab OR a placebo-equivalent every three weeks on Day 1 of each 21-day cycle until disease progression, lack of clinical benefit or unacceptable toxicity is observed.

Age

People 18+

Phase

III

Trial Acronym

SKYSCRAPER-01

More information

Trial Identifiers

Use the hyperlinks, where available to access additional clinical trial information.

NCT04294810
GO41717, CT1254

Commercial Sponsor

Hoffmann-La Roche

Scientific Title

A Phase III, Randomized, Double-Blinded, Placebo-Controlled Study of Tiragolumab, an Anti-Tigit Antibody, in Combination With Atezolizumab Compared With Placebo in Combination With Atezolizumab in Patients With Previously Untreated Locally Advanced Unresectable or Metastatic PD-L1-Selected Non-Small Cell Lung Cancer

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Eligibility

Inclusion

You have certain types of non-cancer medical conditions.
You have been diagnosed with a prior or secondary type of cancer.
You have had certain treatments, surgical procedures or drugs.
You have previously been treated (or are currently being treated) on a clinical trial.

Exclusion

You have been diagnosed with cancer, but have not received any treatment.
Your cancer has spread to other parts of the body.

Clinical trials have complex eligibility criteria.

Ask your doctor if this trial could be right for you.

Participating hospitals

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Closed hospitals

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