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A Phase 1, Multicenter, Open-label, Dose-Exploration and Dose-Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 650 in Subjects With Advanced Solid Tumors
This is a dose exploration and expansion trial. In the dose exploration phase, eligible patients will receive or AMG 650 to understand the maximum tolerated and recommended phase 2 dose (RP2D), which will be estimated using isotonic regression. In the dose expansion phase of the trial, eligible patients will be assigned, according to their cancer diagnosis, to receive the preliminary RP2D of oral AMG 650 identified in the dose exploration phase of the trial.