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RecruitingLast updated: 15 August 2023

KEYNOTE-992: This phase III trial is evaluating the safety and effectiveness of using chemo-radiotherapy with and without immunotherapy for the treatment of patients with muscle-invasive bladder cancerA Phase 3, Randomized, Double-blind, Placebo-controlled Clinical Trial to Study the Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Participants With Muscle-invasive Bladder Cancer (MIBC)

Clinical summary

Summary

Eligible patients will be randomised to receive pembrolizumab or a pembrolizumab-placebo, plus the investigators choice of one of three chemotherapy regimens and radiotherapy.

Conditions

This trial is treating patients with muscle invasive bladder cancer.

Cancer

Urinary System Cancers Urinary System

Age

People18+

Phase

III

Trial Acronym

KEYNOTE-992

More information

Trial Identifiers

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Commercial Sponsor

Merck

Scientific Title

A Phase 3, Randomized, Double-blind, Placebo-controlled Clinical Trial to Study the Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Participants With Muscle-invasive Bladder Cancer (MIBC)

Eligibility

Exclusion

  • You have certain types of non-cancer medical conditions.
  • You have been diagnosed with a prior or secondary type of cancer.
  • You have had certain treatments, surgical procedures or drugs.
  • You have previously been treated (or are currently being treated) on a clinical trial.
Message

Clinical trials have complex eligibility criteria.

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The Victorian Cancer Trials Link is supported by the Victorian Government through the Victorian Cancer Agency.

RAP

Cancer Council Victoria would like to acknowledge the traditional custodians of the land on which we live and work. We would also like to pay respect to the elders past and present and extend that respect to all other Aboriginal people.